On the sensitivity of reactive tabu search to its meta-parameters

In this paper, we assess the sensitivity of reactive tabu search to its meta-parameters. Based on a thorough experimental analysis of reactive tabu search applications to the quadratic assignment and the maximum clique problem, we show that its performance is relatively insensitive to its meta-parameters. This is particularly evident when compared to the sensitivity of tabu search to its parameters: tabu search is rather penalized if used with sub-optimal parameter settings. Reactive tabu search does not strongly pay its high parameter robustness in terms of performance, although it does not improve the peak performance of tabu search.     

Fricke gel dosimetry in boron neutron capture therapy

Gel dosimetry allows three-dimensional (3D) measurement of absorbed dose in tissue-equivalent dosemeter phantoms. Gel phantoms are imaged using optical techniques. In neutron capture therapy (NCT), properly designed gel dosemeters can give 3D dose distributions, due to the various components of the secondary radiation, in phantoms exposed in the thermal or epithermal column of a nuclear reactor. In addition to the therapeutic dose arising from the reaction 10B(n,alpha)7Li, the other dose components are also obtainable, i.e. the gamma dose (due to reactor background and to the reaction 1H(n,gamma)2H of thermal neutrons with hydrogen, the dose due to protons emitted in the reaction 14N(n,p)14C of thermal neutrons with nitrogen and the dose due to recoil protons resulting from elastic scattering of epithermal neutrons.     

Stable tracer investigations in humans for assessing the biokinetics of ruthenium and zirconium radionuclides

The interest in the biokinetics of ruthenium and zirconium in humans is justified by the potential radiological risk represented by their radionuclides. Only a few data related to the biokinetics of ruthenium and zirconium in humans are available and, accordingly, the biokinetic models currently recommended by the ICRP for these elements are mainly based on data from animal experiments. The use of stable isotopes as tracers, coupled with a proper analytical technique (nuclear activation analysis with protons) for their determination in biological samples, represents an ethically acceptable methodology for biokinetic investigations, being free from any radiation risk for the volunteer subjects. In this work, the results obtained in eight biokinetic investigations for ruthenium, conducted on a total of three healthy volunteers, and six for zirconium, performed on a total of three subjects, are presented and compared to the predictions of the ICRP models.     

On the Invariance of Ant Colony Optimization

Ant colony optimization (ACO) is a promising metaheuristic and a great amount of research has been devoted to its empirical and theoretical analysis. Recently, with the introduction of the hypercube framework, Blum and Dorigo have explicitly raised the issue of the invariance of ACO algorithms to transformation of units. They state (Blum and Dorigo, 2004) that the performance of ACO depends on the scale of the problem instance under analysis. In this paper, we show that the ACO internal state - commonly referred to as the pheromone - indeed depends on the scale of the problem at hand. Nonetheless, we formally prove that this does not affect the sequence of solutions produced by the three most widely adopted algorithms belonging to the ACO family: ant system, MAX-MIN ant system, and ant colony system. For these algorithms, the sequence of solutions does not depend on the scale of the problem instance under analysis. Moreover, we introduce three new ACO algorithms, the internal state of which is independent of the scale of the problem instance considered. These algorithms are obtained as minor variations of ant system, MAX-MIN ant system, and ant colony system. We formally show that these algorithms are functionally equivalent to their original counterparts. That is, for any given instance, these algorithms produce the same sequence of solutions as the original ones.     

Environmental biochemistry of current environmental levels of heavy metals: Preparation of radiotracers with very high specific radioactivity for metallobiochemical experiments on laboratory animals

Environmental toxicology research on dose-response relationships of heavy metals requires experiments on laboratory animals exposed to “low doses” of trace elements which should reflect “present or actual environmental levels” characteristic of polluted environments. Unfortunately no criteria exist to establish the “low doses” to which laboratory animals must be exposed, in practice the choice of the level used is made in an almost arbitrary manner. In order to define the “present environmental levels” of heavy metals which should be administered to laboratory animals an approach is suggested, based upon knowledge of the concentrations of trace elements in the diet, air and food as well as the fractions absorbed. Today daily intakes of trace elements by man are of the order of few micrograms or nanograms thus requiring the use of extremely sensitive analytical techniques to determine the very low amounts of heavy metals in tissues and cellular components.In these fields of research the use of radiotracers with very specific radioactivity appears particularly advantageous but requires considerable care during their preparation and use.The first part of this paper deals with a definition of the ranges of concentrations of trace elements which should be used for metabolic studies on laboratory animals when they are exposed via different routes such as ingestion, inhalation or injection; the second part describes the production of radiotracers with very high specific radioactivity by proton activation in the cyclotron and by neutron irradiation in the nuclear reactor. Their use to label present levels of heavy metals under conditions adapted for biochemical purposes, as well as the preparation of different metal-labelled chemical species is also reported. Particular attention is directed to quality control of the radiotracer solutions which are administered to the animals including those of radioactivity concentrations, radioisotopic purity, radiochemical purity, carrier content and chemical impurities.     

Frankenstein's PSO: A Composite Particle Swarm Optimization Algorithm

During the last decade, many variants of the original particle swarm optimization (PSO) algorithm have been proposed. In many cases, the difference between two variants can be seen as an algorithmic component being present in one variant but not in the other. In the first part of the paper, we present the results and insights obtained from a detailed empirical study of several PSO variants from a component difference point of view. In the second part of the paper, we propose a new PSO algorithm that combines a number of algorithmic components that showed distinct advantages in the experimental study concerning optimization speed and reliability. We call this composite algorithm Frankenstein's PSO in an analogy to the popular character of Mary Shelley's novel. Frankenstein's PSO performance evaluation shows that by integrating components in novel ways effective optimizers can be designed.     

The Metaphysical Character of the Criticisms Raised Against the Use of Probability for Dealing with Uncertainty in Artificial Intelligence

In artificial intelligence (AI), a number of criticisms were raised against the use of probability for dealing with uncertainty. All these criticisms, except what in this article we call the non-adequacy claim, have been eventually confuted. The non-adequacy claim is an exception because, unlike the other criticisms, it is exquisitely philosophical and, possibly for this reason, it was not discussed in the technical literature. A lack of clarity and understanding of this claim had a major impact on AI. Indeed, mostly leaning on this claim, some scientists developed an alternative research direction and, as a result, the AI community split in two schools: a probabilistic and an alternative one. In this article, we argue that the non-adequacy claim has a strongly metaphysical character and, as such, should not be accepted as a conclusive argument against the adequacy of probability.