Physiologic effects of a self-contained self-rescuer

Recently promulgated federal regulations mandate the provision of an emergency, self-contained, oxygen-supplying breathing device (self-contained self-rescuer, SCSR) to all underground coalminers. In order to assist in defining the potential limitations of this new device, we measured the responses of ten healthy coal mine inspectors to submaximal steady-state treadmill exercise with and without the SCSR. During the last minute of exercise, blood oxygen saturation averaged 98.3% and mouth pressure swing 15.6 cm H2O with the device, compared to 94.8% and 10.4 cm H2O without it. Mean respiratory rates were decreased to 25/min with the SCSR from 28/min without it. Blood pressure, core temperature and heart rate were unaffected. We conclude that in healthy individuals on submaximal exercise there is little evidence of a significant adverse effect of the new device.     

Network Model for Rural Roadway Tolling with Pavement Deterioration and Repair

The objective of roadway tolling in rural areas is often tied to revenue generation for roadway maintenance. Thus, rural pricing models should directly incorporate a pavement deterioration and maintenance model. However, the interactions between these models are not simple, because tolls cause traffic diversion, which in turn affects deterioration rates and forecasted revenue. This article describes a rural pricing model which calculates diversion endogenously with a network assignment model. This model captures deterioration rates and pavement condition in the toll‐setter's objective function, maximizing long‐run net present value of the highway infrastructure. A novel deterioration model is used which is particularly suitable for computational efficiency. The resulting model is discontinuous and nondifferentiable, and involves solving a combinatorial knapsack problem as a subproblem. Thus, a simulated annealing‐based algorithm is presented to solve it, in the framework of a new solution method built upon partitioning the feasible region. A demonstration is made using a network representing the state of Wyoming (28 zones, 60 nodes, and 188 links). Sensitivity analyses reveal that although the locations for optimal tolling are relatively stable as demand changes, the revenue collected can vary substantially. Relatively simple models are used throughout for computational reasons, and future research should investigate strategies for incorporating more advanced pavement and network models.     

Demand Profiling for Dynamic Traffic Assignment by Integrating Departure Time Choice and Trip Distribution

One challenge in dynamic traffic assignment (DTA) modeling is estimating the finely disaggregated trip matrix required by such models. In previous work, an exogenous time distribution profile for trip departure rates is applied uniformly across all origin‐destination (O‐D) pairs. This article develops an endogenous departure time choice model based on an arrival time penalty function incorporated into trip distribution, which results in distinct demand profiles by O‐D pair. This yields a simultaneous departure time and trip choice making use of the time‐varying travel times in DTA. The required input is arrival time preferences, which can be disaggregated by O‐D pair and may be easier to collect through surveys than the demand profile. This model is integrated into the four‐step planning process with feedback, creating an extension of previous frameworks which aggregate over time. Empirical results from a network representing Austin, Texas indicate variation in departure time choice appropriate to the arrival time penalties and travel times. Our model also appears to converge faster to a dynamic trip table prediction than a time‐aggregated coupling of DTA and planning, potentially reducing the substantial computation time of combined planning models that solve DTA as a subproblem of a feedback process.     

Synthesis of biphenylated cyanate esters: Thermomechanical resin comparisons within two isomeric series

Three isomeric tetraaryl cyanate esters containing biphenyl moieties {bis‐[4‐(4′‐cyanatophenyl)phenyl]propane, 2,2‐bis‐[4‐(3′‐cyanatophenyl)phenyl]propane, and 2,2‐bis‐[4‐(2′‐cyanatophenyl)phenyl]propane} and three isomeric triaryl cyanate esters {2‐(4′‐hydroxyphenyl)‐2‐[4′‐(4‐hydroxyphenyl)phenyl]propane, 2‐(4′‐hydroxyphenyl)‐2‐[4′‐(3‐hydroxyphenyl)phenyl]propane, and 2‐(4′‐hydroxyphenyl)‐2‐[4′‐(2‐hydroxyphenyl)phenyl]propane} were synthesized from their corresponding bisphenols. The structures of the monomers were confirmed with IR and ¹H‐NMR spectroscopy. The curing behavior was investigated with differential scanning calorimetry. Cyanate esters were cured thermally in the absence of a catalyst and were characterized by dynamic mechanical analysis. The results were compared to the properties of commercial bisphenol A polycyanurate. Of the three tetraaryl isomers, 2,2‐bis‐[4‐(2′‐cyanatophenyl)phenyl]propane had the highest melting point, and its corresponding resin had the lowest glass‐transition temperature (T_g). The para isomer displayed the highest T_g value of the three novel tetraaryl resins. The triaryl dicyanate isomers were low‐melting solids, with the ortho and meta isomers existing as liquids at room temperature. The T_g value of the para‐triaryl isomer was the highest of the three triaryl isomers and was about the same as that of bisphenol A polycyanurate. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011     

Life event stress and the association with spontaneous abortion in gravid women at an urban emergency department.

In this study, the authors hypothesized that life event stress is associated with an increased risk of spontaneous abortion. Using a nested case-control design in an emergency department (N?=?970), stress was measured using a life event inventory and a sample drawn from R. B. Ness et al's (1999) Early Pregnancy Study. Gestational age at time of fetal loss served as a marker of chromosomal status. Women experiencing more than one life event used more alcohol and public assistance. Spontaneous abortion at 11 weeks or greater was associated with more life event stress (adjusted odds ratio 2.9, 95% confidence interval 1.4–6.2), whereas spontaneous abortion at any gestational age was not, implying that life event stress increases the risk of chromosomally normal spontaneous abortion. An analysis of confounders showed tobacco use was associated with an increased risk of spontaneous abortion, whereas prenatal care was only associated with fetal loss at 11 weeks or greater. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Exploring diverse sorghum (Sorghum bicolor (L.) Moench) accessions for malt amylase activity

Sorghum is a climate resilient grain cereal crop originating from Africa that has traditionally been used to make a variety of fermented beverages such as pito and baijiu. In Western markets, the use of sorghum to produce beers and beverages has recently risen due to the visibility of a gluten sensitive/intolerant market and a growing interest in unique inputs for beverage production. As such, there is a developing body of research on sorghum as a malted input into beverages. A major limitation to the wider adoption of sorghum as a substrate in mashing is its low activity of amylolytic enzymes, either the result of insufficient activity or inhibition by endogenous compounds. A collection of 42 diverse accessions representing the grain sorghum diversity panel, was evaluated for associations between alpha and beta amylase content, race, origin, and seed colour as well as two classes of amylase inhibitors, phenols and tannins. Among these accessions are several commonly used genetic resources, including reference line BTx623. Notable findings include accessions with high alpha amylase content, sources that may harbour additional high amylase sorghums, associations with grain colour, and populations which may be used to genetically map the trait. © 2020 The Authors. Journal of the Institute of Brewing published by John Wiley & Sons Ltd on behalf of The Institute of Brewing & Distilling     

Why friendly AIs won’t be that friendly: a friendly reply to Muehlhauser and Bostrom

In “Why We Need Friendly AI”, Luke Muehlhauser and Nick Bostrom propose that for our species to survive the impending rise of superintelligent AIs, we need to ensure that they would be human-friendly. This discussion note offers a more natural but bleaker outlook: that in the end, if these AIs do arise, they won’t be that friendly.