Polymorphisms in EGFR Gene Predict Clinical Outcome in Unresectable Non-Small Cell Lung Cancer Treated with Radiotherapy and Platinum-Based Chemoradiotherapy

For non-small cell lung cancer (NSCLC), radiotherapy (RT) and platinum-based chemotherapy (CHT) are among the main treatment options. On the other hand, radioresistance and cytotoxic drug resistance are common causes of failure. The epidermal growth factor receptor (EGFR) plays an important role in radioresponse and therapy resistance. We hypothesized that single nucleotide polymorphisms (SNPs) in the EGFR gene might affect individual sensitivity to these treatments, and thus, therapy outcome and prognosis. The association between functional EGFR SNPs and overall (OS), locoregional recurrence-free (LFRS), and metastasis-free (MFS) survival was examined in 436 patients with unresectable NSCLC receiving RT and platinum-based CHTRT. In a multivariate analysis, the rs712830 CC homozygotes showed reduced OS in the whole group (p = 0.039) and in the curative treatment subset (p = 0.047). The rs712829 TT genotype was strongly associated with decreased LRFS (p = 0.006), and the T-C haplotype was a risk factor for locoregional recurrence in our patients (p = 0.003). The rs2227983 GG alone and in combination with rs712829 T was an indicator of unfavorable LRFS (p = 0.028 and 0.002, respectively). Moreover, significant independent effects of these SNPs on OS, LRFS, and MFS were observed. Our results demonstrate that inherited EGFR gene variants may predict clinical outcomes in NSCLC treated with DNA damage-inducing therapy.     

Legible Simplification of Textured Urban Models

Most of the algorithms used for research in mesh simplification and discrete levels of detail (LOD) work well for simplifying single objects with a large number of polygons. For a city-sized collection of simple buildings, using these traditional algorithms could mean the disappearance of an entire residential area in which the buildings tend to be smaller than those in commercial regions. To solve this problem, we developed a mesh-simplification algorithm that incorporates concepts from architecture and city planning. Specifically, we rely on the concept of urban legibility, which segments a city into paths, edges, districts, nodes, and landmarks. If we preserve these elements of legibility during the simplification process, we can maintain the city's image and create urban models that users can understand more effectively. To accomplish this goal, we divide our algorithm into five steps. During preprocessing, it performs hierarchical clustering, cluster merging, model simplification, and hierarchical texturing, at runtime, it employs LOD to select the appropriate models for rendering.     

Steady-state error of a system with fuzzy controller

We consider the problem of control error of a fuzzy system with feedback. The system consists of a plant, linear or nonlinear, fuzzy controller, and feedback loop. As controller we use both PD and PI fuzzy type controllers. We apply different t-norm and co-norm: logic, algebraic, Yager, Hamacher, bounded, drastic, etc. in the process of fuzzy reasoning. Triangular shape of membership functions is supposed, but we generalize the results obtained. Steady-state error of a system is calculated. We have obtained very interesting results. The steady-state error is identical for pairs of triangular t- and co-norms.     

Visual Analysis and Semantic Exploration of Urban LIDAR Change Detection

Many previous approaches to detecting urban change from LIDAR point clouds interpolate the points into rasters, perform pixel‐based image processing to detect changes, and produce 2D images as output. We present a method of LIDAR change detection that maintains accuracy by only using the raw, irregularly spaced LIDAR points, and extracts relevant changes as individual 3D models. We then utilize these models, alongside existing GIS data, within an interactive application that allows the chronological exploration of the changes to an urban environment. A three‐tiered level‐of‐detail system maintains a scale‐appropriate, legible visual representation across the entire range of view scales, from individual changes such as buildings and trees, to groups of changes such as new residential developments, deforestation, and construction sites, and finally to larger regions such as neighborhoods and districts of a city that are emerging or undergoing revitalization. Tools are provided to assist the visual analysis by urban planners and historians through semantic categorization and filtering of the changes presented.     

Alleviating the Modifiable Areal Unit Problem within Probe‐Based Geospatial Analyses

We present a probe‐based interface for the exploration of the results of a geospatial simulation of urban growth. Because our interface allows the user great freedom in how they choose to define regions‐of‐interest to examine and compare, the classic geospatial analytic issue known as the modifiable areal unit problem (MAUP) quickly arises. The user may delineate regions with unseen differences that can affect the fairness of the comparisons made between them. To alleviate this problem, our interface first alerts the user if it detects any potential unfairness between regions when they are selected for comparison. It then presents the dimensions with potential problematic outliers to the user for evaluation. Finally, it provides a number of semi‐automated tools to assist the user in correcting their regions' boundaries to minimize the inequalities they feel could significantly impact their comparisons.     

Hairy Slices II: Depth Cues for Visualizing 3D Streamlines Through Cutting Planes

Visualizing 3D vector fields is challenging because of occlusion problems and the difficulty of providing depth cues that adequately support the perception of direction of flow lines in 3D space. One of the depth cues that has proven most valuable for the perception of other kinds of 3D data, notably 3D networks and 3D point clouds, is structure-from-motion (also called the Kinetic Depth Effect); another powerful depth cue is stereoscopic viewing. We carried out an experiment of the perception of direction for short streamlines passing through a cutting plane. The conditions included viewing with and without structure-from-motion and with and without stereoscopic depth. Conditions also include comparing streamtubes to lines. The results show that for this particular task, stereo provided an effective depth cue, but structure-from-motion did not. Ringed streamtubes and streamcones provided good 3D direction information, even without stereoscopic viewing. We conclude with guidelines for viewing slices through vector fields.     

Multi-focused geospatial analysis using probes

Traditional geospatial information visualizations often present views that restrict the user to a single perspective. When zoomed out, local trends and anomalies become suppressed and lost; when zoomed in for local inspection, spatial awareness and comparison between regions become limited. In our model, coordinated visualizations are integrated within individual probe interfaces, which depict the local data in user-defined regions-of-interest. Our probe concept can be incorporated into a variety of geospatial visualizations to empower users with the ability to observe, coordinate, and compare data across multiple local regions. It is especially useful when dealing with complex simulations or analyses where behavior in various localities differs from other localities and from the system as a whole. We illustrate the effectiveness of our technique over traditional interfaces by incorporating it within three existing geospatial visualization systems: an agent-based social simulation, a census data exploration tool, and an 3D GIS environment for analyzing urban change over time. In each case, the probe-based interaction enhances spatial awareness, improves inspection and comparison capabilities, expands the range of scopes, and facilitates collaboration among multiple users.     

Evaluation of gap formation at the composite resin‐tooth interface after using universal adhesives: In vitro SEM study using the replica technique

The aim of this study was to evaluate gap formation after using two universal adhesives, Peak Universal Bond (P), which contains chlorhexidine and Adhese Universal (A), which contains 10‐MDP monomer, and to compare them with two gold standard adhesives. The adhesives were tested in different etching modes, etch‐and‐rinse (ER) or self‐etch (SE), and under thermomechanical loading (TML). Two identical Class V cavities were prepared in each of 30 human third molar teeth, and resin‐composite restorations were made. Before and after TML, replicas of the restorations were prepared. Gap formation and their frequency according to the modified classification of Blunck and Zaslansky and the width of the maximum marginal gap (MG) were separately evaluated in enamel and dentin. Gap frequency did not differ significantly only in the enamel before TML, despite the use of different adhesives or etching modes. At both timepoints, the highest MG values were obtained with the Peak Universal Bond self‐etch (PSE) group in enamel (6.2 μm before TML, 12.2 μm after TML) and the Peak Universal Bond etch‐and‐rinse (PER) group in dentine (21.3 μm before TML, 35.5 μm after TML). After TML, there was a significant increase of gap frequency for Adhese universal self‐etch (ASE) group and MG values for PER, PSE, ASE groups at the resin‐enamel interface, and gap frequency and MG values for all groups at the resin‐dentin interface. Universal adhesive with 10‐MDP monomer have beneficial effect on the resin‐dentin interface, while chlorhexidine may reduce the resistance of the universal adhesive system to oral cavity conditions.     

Thermoelectrical degradation processes in NTC thermistors for in-rush current protection of electronic circuits

Degradation processes, caused by the extreme values of current pulses or thermal burn-in, are studied in thermistors with negative temperature coefficient of resistance. The drift of thermistor resistance at 25°C is observed. These changes depend on the value and the number of current pulses. The first 100 cycles are the basic ones for the future exploitation parameters of thermistors. Similar effect, rise of thermistor resistance, was observed after burn-in. The investigated thermistors are used for in-rush current protection of electronic circuits.