Iterative reengineering of legacy systems

During its life, a legacy system is subjected to many maintenance activities, which cause degradation of the quality of the system: When this degradation exceeds a critical threshold, the legacy system needs to be reengineered. In order to preserve the asset represented by the legacy system, the familiarity with it gained by the system's maintainers and users, and the continuity of execution of current operations during the reengineering process, the system needs to be reengineered gradually. Moreover, each program needs to be reengineered within a short period of time. The paper proposes a reengineering process model, which is applied to an in-use legacy system to confirm that the process satisfies previous requirements and to measure its effectiveness. The reengineered system replaced the legacy one to the satisfaction of all the stakeholders; the reengineering process also had a satisfactory impact on the quality of the system. Finally, this paper contributes to validate the cause-effect relationship between the reengineering process and overcoming the aging symptoms of a software system.     

A cross‐cultural comparison of colour emotion for two‐colour combinations

Psychophysical experiments were conducted in the UK, Taiwan, France, Germany, Spain, Sweden, Argentina, and Iran to assess colour emotion for two‐colour combinations using semantic scales warm/cool, heavy/light, active/passive, and like/dislike. A total of 223 observers participated, each presented with 190 colour pairs as the stimuli, shown individually on a cathode ray tube display. The results show consistent responses across cultures only for warm/cool, heavy/light, and active/passive. The like/dislike scale, however, showed some differences between the observer groups, in particular between the Argentinian responses and those obtained from the other observers. Factor analysis reveals that the Argentinian observers preferred passive colour pairs to active ones more than the other observers. In addition to the cultural difference in like/dislike, the experimental results show some effects of gender, professional background (design vs. nondesign), and age. Female observers were found to prefer colour pairs with high‐lightness or low‐chroma values more than their male counterparts. Observers with a design background liked low‐chroma colour pairs or those containing colours of similar hue more than nondesign observers. Older observers liked colour pairs with high‐lightness or high‐chroma values more than young observers did. Based on the findings, a two‐level theory of colour emotion is proposed, in which warm/cool, heavy/light, and active/passive are identified as the reactive‐level responses and like/dislike the reflective‐level response. © 2010 Wiley Periodicals, Inc. Col Res Appl, 2012     

Fixed range scales applied to the evaluation of color: Comparative analysis between the Munsell System and the Natural Color System

In this article, we discuss the effect of anchoring on the estimation of chromatic variables, which occurs when fixed range scales are used in psychophysical measuring. In order to do this, we compare the Munsell System and the Natural Color System (NCS), and an alternative system that employs a scale of grays as a yardstick against which to measure value and saturation. During experimentation, observers evaluated 60 matte surface color samples, following the methodology proposed by each system, but without using their respective color atlases. The data obtained reveal results that are compatible with the measurements based on the Munsell System and the NCS. By applying the gray‐scale method, the value measurements improved, whereas the saturation measurements were overestimated in samples with low reflectance. In all the cases, hue shifts were observed and thought to be attributable to the variation in luminance revealed by the samples. Judging by the similarity of the results obtained, it can be assumed that when fixed range scales are used, measurements will be anchored to their extremes, equaling every measurement made with them. © 2003 Wiley Periodicals, Inc. Col Res Appl, 28, 103–112, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.10130     

Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine

Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM) which may represent a valid model for high-risk MM. This disease is associated with a very poor prognosis, and unfortunately, it has not significantly improved during the last three decades. New high-throughput technologies have allowed a better understanding of the molecular basis of this disease and moved toward risk stratification, providing insights for targeted therapy studies. This knowledge, added to the pharmacogenetic profile of new and old agents in the analysis of efficacy and safety, could contribute to help clinical decisions move toward a precision medicine and a better clinical outcome for these patients. In this review, we describe the available literature concerning the genomic characterization and pharmacogenetics of plasma cell leukemia (PCL).     

Design and Characterization of a Peptide Mimotope of the HIV-1 gp120 Bridging Sheet

The Bridging Sheet domain of HIV-1 gp120 is highly conserved among the HIV-1 strains and allows HIV-1 binding to host cells via the HIV-1 coreceptors. Further, the bridging sheet domain is a major target to neutralize HIV-1 infection. We rationally designed four linear peptide epitopes that mimic the three-dimensional structure of bridging sheet by using molecular modeling. Chemically synthesized peptides BS3 and BS4 showed a fair degree of antigenicity when tested in ELISA with IgG purified from HIV(+) broadly neutralizing sera while the production of synthetic peptides BS1 and BS2 failed due to their high degree of hydrophobicity. To overcome this limitation, we linked all four BS peptides to the COOH-terminus of GST protein to test both their antigenicity and immunogenicity. Only the BS1 peptide showed good antigenicity; however, no envelope specific antibodies were elicited upon mice immunization. Therefore we performed further analyses by linking BS1 peptide to the NH2-terminus of the E2 scaffold from the Geobacillus Stearothermophylus PDH complex. The E2-BS1 fusion peptide showed good antigenic results, however only one immunized rabbit elicited good antibody titers towards both the monomeric and oligomeric viral envelope glycoprotein (Env). In addition, moderate neutralizing antibodies response was elicited against two HIV-1 clade B and one clade C primary isolates. These preliminary data validate the peptide mimotope approach as a promising tool to obtain an effective HIV-1 vaccine.     

Time‐series models with an EGB2 conditional distribution

A time‐series model in which the signal is buried in noise that is non‐Gaussian may throw up observations that, when judged by the Gaussian yardstick, are outliers. We describe an observation‐driven model, based on an exponential generalized beta distribution of the second kind (EGB2), in which the signal is a linear function of past values of the score of the conditional distribution. This specification produces a model that is not only easy to implement but which also facilitates the development of a comprehensive and relatively straightforward theory for the asymptotic distribution of the maximum‐likelihood (ML) estimator. Score‐driven models of this kind can also be based on conditional t distributions, but whereas these models carry out what, in the robustness literature, is called a soft form of trimming, the EGB2 distribution leads to a soft form of Winsorizing. An exponential general autoregressive conditional heteroscedastic (EGARCH) model based on the EGB2 distribution is also developed. This model complements the score‐driven EGARCH model with a conditional t distribution. Finally, dynamic location and scale models are combined and applied to data on the UK rate of inflation.     

Color and Sound: Physical and Psychophysical Relations*

Many artists and scientists have been concerned, throughout time, with the correspondences between color and sound. Numerous studies on the subject have been written. There are approaches based on intuition as well as approaches based on psychology, psychophysics, physics, and physiology The classical comparison relies on the fact that the stimuli for the sensations of pitch in sound and hue in color are mainly determined by the wavelength of the auditory energy and the visible energy. both taken as undulatory phenomena. On this basis. a comparison is usually drawn between the chromatic scale of sounds and the hue circle. This criterion has been followed to such extent to relate a sound of specific frequency with a determined spectral color. The comparison can be expanded and refined by considering the other variables of sound and color. too. This article relates luminosity of color with loudness of sound. saturation of color with timbre of sound, and size of color with duration of sound. There are psychological and physical arguments to support such a comparison. © 1994 John Wiley & Sons, Inc.     

Cesia: A system of visual signs complementing color

Color theory has been worked up by some researchers in order to consider factors such as transparence, brightness, opacity, etc., but no color order system has been devised to include these variables in addition to the usual three. This work proposes to treat these factors as theoretically separate from color (even if they are related with it), developing an order system for them. When it is taken parallel to color, this system helps to describe all the visual perceptions produced by light stimuli.