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排序方式: 共有537条查询结果,搜索用时 31 毫秒
1.
Antonio Mancini Carmine Bruno Edoardo Vergani Claudia dAbate Elena Giacchi Andrea Silvestrini 《International journal of molecular sciences》2021,22(4)
The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different mechanisms could contribute to hyperandrogenism and anovulation, which are the main features of the syndrome. Obesity and insulin-resistance are claimed as the principal factors contributing to the clinical presentation; in normal weight PCOS either, increased visceral adipose tissue has been described. However, their role is still debated, as debated are the biochemical markers linked to obesity per se. Oxidative stress (OS) and low-grade inflammation (LGI) have recently been a matter of researcher attention; they can influence each other in a reciprocal vicious cycle. In this review, we summarize the main mechanism of radical generation and the link with LGI. Furthermore, we discuss papers in favor or against the role of obesity as the first pathogenetic factor, and show how OS itself, on the contrary, can induce obesity and insulin resistance; in particular, the role of GH-IGF-1 axis is highlighted. Finally, the possible consequences on vitamin D synthesis and activation on the immune system are briefly discussed. This review intends to underline the key role of oxidative stress and low-grade inflammation in the physiopathology of PCOS, they can cause or worsen obesity, insulin-resistance, vitamin D deficiency, and immune dyscrasia, suggesting an inverse interaction to what is usually considered. 相似文献
2.
Gennaro Costagliola Vincenzo Deufemia Filomena Ferrucci Carmine Gravino 《Information and Computation》2003,187(2):209-245
Drawn symbolic pictures are an extension of drawn pictures obtained by associating a symbol from an alphabet to each point of the picture. In the paper we will address some new interesting issues derived from the introduction of the symbols and we will identify the conditions, which ensure the preservation of properties holding for drawn pictures in the setting of the proposed extension. 相似文献
3.
Laura Francesca Pisani Gian Eugenio Tontini Carmine Gentile Beatrice Marinoni Isabella Teani Nicoletta Nandi Pasquale Creo Emanuele Asti Luigi Bonavina Maurizio Vecchi Luca Pastorelli 《International journal of molecular sciences》2021,22(11)
Interleukin (IL)-33 is a member of the interleukin (IL)-1 family of cytokines linked to the development of inflammatory conditions and cancer in the gastrointestinal tract. This study is designed to investigate whether IL-33 has a direct effect on human gastric epithelial cells (GES-1), the human gastric adenocarcinoma cell line (AGS), and the gastric carcinoma cell line (NCI-N87) by assessing its role in the regulation of cell proliferation, migration, cell cycle, and apoptosis. Cell cycle regulation was also determined in ex vivo gastric cancer samples obtained during endoscopy and surgical procedures. Cell lines and tissue samples underwent stimulation with rhIL-33. Proliferation was assessed by XTT and CFSE assays, migration by wound healing assay, and apoptosis by caspase 3/7 activity assay and annexin V assay. Cell cycle was analyzed by means of propidium iodine assay, and gene expression regulation was assessed by RT-PCR profiling. We found that IL-33 has an antiproliferative and proapoptotic effect on cancer cell lines, and it can stimulate proliferation and reduce apoptosis in normal epithelial cell lines. These effects were also confirmed by the analysis of cell cycle gene expression, which showed a reduced expression of pro-proliferative genes in cancer cells, particularly in genes involved in G0/G1 and G2/M checkpoints. These results were confirmed by gene expression analysis on bioptic and surgical specimens. The aforementioned results indicate that IL-33 may be involved in cell proliferation in an environment- and cell-type-dependent manner. 相似文献
4.
In recent years, cubic regularization algorithms for unconstrained optimization have been defined as alternatives to trust-region and line search schemes. These regularization techniques are based on the strategy of computing an (approximate) global minimizer of a cubic overestimator of the objective function. In this work we focus on the adaptive regularization algorithm using cubics (ARC) proposed in Cartis et al. [Adaptive cubic regularisation methods for unconstrained optimization. Part I: motivation, convergence and numerical results, Mathematical Programming A 127 (2011), pp. 245–295]. Our purpose is to design a modified version of ARC in order to improve the computational efficiency preserving global convergence properties. The basic idea is to suitably combine a Goldstein-type line search and a nonmonotone accepting criterion with the aim of advantageously exploiting the possible good descent properties of the trial step computed as (approximate) minimizer of the cubic model. Global convergence properties of the proposed nonmonotone ARC algorithm are proved. Numerical experiments are performed and the obtained results clearly show satisfactory performance of the new algorithm when compared to the basic ARC algorithm. 相似文献
5.
Antonio Negretti Albert Benseny Jordi Mompart Tommaso Calarco 《Quantum Information Processing》2013,12(3):1439-1467
We numerically investigate the performance of atomic transport in optical microtraps via the so called spatial adiabatic passage technique. Our analysis is carried out by means of optimal control methods, which enable us to determine suitable transport control pulses. We investigate the ultimate limits of the optimal control in speeding up the transport process in a triple well configuration for both a single atomic wave packet and a Bose-Einstein condensate within a regime of experimental parameters achievable with current optical technology. 相似文献
6.
Antonio Negretti Philipp Treutlein Tommaso Calarco 《Quantum Information Processing》2011,10(6):721-753
We review quantum information processing with cold neutral particles, that is, atoms or polar molecules. First, we analyze
the best suited degrees of freedom of these particles for storing quantum information, and then we discuss both single- and
two-qubit gate implementations. We focus our discussion mainly on collisional quantum gates, which are best suited for atom-chip-like
devices, as well as on gate proposals conceived for optical lattices. Additionally, we analyze schemes both for cold atoms
confined in optical cavities and hybrid approaches to entanglement generation, and we show how optimal control theory might
be a powerful tool to enhance the speed up of the gate operations as well as to achieve high fidelities required for fault
tolerant quantum computation. 相似文献
7.
Tommaso Mansi Xavier Pennec Maxime Sermesant Hervé Delingette Nicholas Ayache 《International Journal of Computer Vision》2011,92(1):92-111
Tracking soft tissues in medical images using non-linear image registration algorithms requires methods that are fast and
provide spatial transformations consistent with the biological characteristics of the tissues. LogDemons algorithm is a fast
non-linear registration method that computes diffeomorphic transformations parameterised by stationary velocity fields. Although
computationally efficient, its use for tissue tracking has been limited because of its ad-hoc Gaussian regularisation, which hampers the implementation of more biologically motivated regularisations. In this work, we
improve the logDemons by integrating elasticity and incompressibility for soft-tissue tracking. To that end, a mathematical
justification of demons Gaussian regularisation is proposed. Building on this result, we replace the Gaussian smoothing by
an efficient elastic-like regulariser based on isotropic differential quadratic forms of vector fields. The registration energy
functional is finally minimised under the divergence-free constraint to get incompressible deformations. As the elastic regulariser
and the constraint are linear, the method remains computationally tractable and easy to implement. Tests on synthetic incompressible
deformations showed that our approach outperforms the original logDemons in terms of elastic incompressible deformation recovery
without reducing the image matching accuracy. As an application, we applied the proposed algorithm to estimate 3D myocardium
strain on clinical cine MRI of two adult patients. Results showed that incompressibility constraint improves the cardiac motion
recovery when compared to the ground truth provided by 3D tagged MRI. 相似文献
8.
9.
Tommaso Bolognesi 《Information Processing Letters》2009,109(13):668-674
Based on the mobile automaton model, an algorithm is introduced that grows planar, tri-valent graphs by exhibiting a peculiar, twofold dynamics. In a first phase, graph growth appears to be pseudo-random and O(n) then it settles to a very regular behavior and rate. A pseudo-random mobile automaton is already known; the new automaton provides now a finite, but surprisingly long, pseudo-random, linear growth process. Applications of mobile automata to fundamental physics and quantum gravity have been recently suggested. 相似文献
10.
George KousiourisAuthor Vitae Tommaso CucinottaAuthor Vitae 《Journal of Systems and Software》2011,84(8):1270-1291
The aim of this paper is to study and predict the effect of a number of critical parameters on the performance of virtual machines (VMs). These parameters include allocation percentages, real-time scheduling decisions and co-placement of VMs when these are deployed concurrently on the same physical node, as dictated by the server consolidation trend and the recent advances in the Cloud computing systems. Different combinations of VM workload types are investigated in relation to the aforementioned factors in order to find the optimal allocation strategies. What is more, different levels of memory sharing are applied, based on the coupling of VMs to cores on a multi-core architecture. For all the aforementioned cases, the effect on the score of specific benchmarks running inside the VMs is measured. Finally, a black box method based on genetically optimized artificial neural networks is inserted in order to investigate the degradation prediction ability a priori of the execution and is compared to the linear regression method. 相似文献