Intramolecular crosslinking of poly(vinyl alcohol)

Poly(vinyl alcohol) is crosslinked in dilute solution (c=0.1 wt%) with glutaraldehyde. The reaction product is characterized by viscometry and gel permeation chromatography (g.p.c.). The intrinsic viscosity decreases with increasing degree of crosslinking and does not depend on temperature. G.p.c. reveals that the reaction product is not homogeneous, but consists of a mixture of particles with different sizes, possibly both intra- and intermolecularly crosslinked molecules. The intramolecularly crosslinked molecules are smaller in size than the initial polymer molecules and their size depends on the degree of crosslinking. They possess a narrow particle size distribution even if the initial polymer sample had a broad molecular weight distribution.     

The Influence of Model Parameters on BEG/MEG Single Dipole Source Estimation

This paper deals with source localization and strength estimation based on EEG and MEG data. It describes an estimation method (inverse procedure) which uses a four-spheres model of the head and a single current dipole. The dependency of the inverse solution on model parameters is investigated. It is found that sphere radii and conductivities influence especially the strength of the EEG equivalent dipole and not its location or direction. The influence on the equivalent dipole of the gradiometer is investigated. In general the MEG produces better location estimates than the EEG whereas the reverse is found for the component estimates. An inverse solution simultaneously based on EEG and MEG data appears slightly better than the average of separate EEG and MEG solutions. Variances of parameter estimators which can be calculated on the basis of a linear approximation of the model, were tested by Monte Carlo simulations.     

Affordances, perceptual complexity, and the development of tool use.

Perceiving the affordance of a tool requires the integration of several complementary relationships among actor, tool, and target. Higher order affordance structures are introduced to deal with these forms of complex action from an ecological-realist point of view. The complexity of the higher order affordance structure was used to predict the difficulty of perceiving the tool function. Predictions were tested in 3 experiments involving children between 9 mo and 4 yrs old. In a classical tool use task dating back to W. K?hler (1921), a desirable target was obtained by using a hook as a tool. The relative positions of the hook and the target were systematically varied to obtain structures differing in complexity. The observed difficulty of the task was found essentially in accordance with the theoretical complexity of the higher order affordance structures involved in perceiving the tool function. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Adding semantics to image-region annotations with the Name-It-Game

In this paper we present the Name-It-Game, an interactive multimedia game fostering the swift creation of a large data set of region-based image annotations. Compared to existing annotation games, we consider an added semantic structure, by means of the WordNet ontology, the main innovation of the Name-It-Game. Using an ontology-powered game, instead of the more traditional annotation tools, potentially makes region-based image labeling more fun and accessible for every type of user. However, the current games often present the players with hard-to-guess objects. To prevent this from happening in the Name-It-Game, we successfully identify WordNet categories which filter out hard-to-guess objects. To verify the speed of the annotation process, we compare the online Name-It-Game with a desktop tool with similar features. Results show that the Name-It-Game outperforms this tool for semantic region-based image labeling. Lastly, we measure the accuracy of the produced segmentations and compare them with carefully created LabelMe segmentations. Judging from the quantitative and qualitative results, we believe the segmentations are competitive to those of LabelMe, especially when averaged over multiple games. By adding semantics to region-based image annotations, using the Name-It-Game, we have opened up an efficient means to provide precious labels in a playful manner.     

The Influence of Evolutionary Selection Schemes on the Iterated Prisoner's Dilemma

Many economic and social systems are essentially large multi-agent systems.By means of computational modeling, the complicated behavior of such systemscan be investigated. Modeling a multi-agent system as an evolutionary agentsystem, several important choices have to be made for evolutionary operators.Especially, it is to be expected that evolutionary dynamics substantiallydepend on the selection scheme. We therefore investigate the influence ofevolutionary selection mechanisms on a fundamental problem: the iteratedprisoner's dilemma (IPD), an elegant model for the emergence of cooperationin a multi-agent system. We observe various types of behavior, cooperationlevel, and stability, depending on the selection mechanism and the selectionintensity. Hence, our results are important for (1) the proper choice andapplication of selection schemes when modeling real economic situations and(2) assessing the validity of the conclusions drawn from computer experimentswith these models. We also conclude that the role of selection in theevolution of multi-agent systems should be investigated further, for instanceusing more detailed and complex agent interaction models.     

Creating a Competitive Advantage through Quality

It is becoming more and more important for companies to have an optimal alignment between business strategy and information strategy. The approach developed in Hewlett-Packard is one way to achieve this. Proper alignment and embeddedness within the IT environment is needed to realise business objectives to achieve competitive advantage. Effectiveness and flexibility are the key-words to ensure competitive advantage by delivering a maximum service level to the customers, by reacting adequately on market changes and to optimise the business processes. Harvesting the creativity of users is an important aspect of the process. ‘Our fundamental goal is to build positive, long-term relationships with our customers, relationships characterised by mutual respect, by courtesy and integrity, by a helpful, effective response to customer needs and concerns, and by a strong commitment to providing products and services of the highest quality.’ (extracted from Hewlett-Packard’s Corporate Objectives for Customers) One of the objectives of Hewlett-Packard is to create a competitive advantage both for the customers and the company by selling and delivering quality business solutions. This objective and the globalisation of our services ask for a business solution delivery approach based on standard products and in conformity with internationally accepted standards. The quality of the business solution delivery process is managed through the project delivery process. The customer’s business solution delivery appreciation is an implicit result of the quality of each individual project. This quality is based on international standards and generic company methodologies. These standards and methodologies combined with the quality of the people are the drivers for the embedding of quality within the entire organisation. The resulting total quality approach triggers a continuous quality improvement process in order to guarantee a win-win situation for both the customer and Hewlett-Packard. For the delivery of quality business solutions there must be a homogeneous set of quality objectives, performance goals, quality system implementation guidelines and a strategy for continuous quality improvement. Within Hewlett-Packard, the Project Management Services department is responsible for the project delivery process with which the quality of the business solution delivery is managed. This paper describes how this is done.     

The VEGF Inhibitor Soluble Fms-like Tyrosine Kinase 1 Does Not Promote AKI-to-CKD Transition

(1) Background: Soluble Fms-like tyrosine kinase 1 (sFLT1) is an endogenous VEGF inhibitor. sFLT1 has been described as an anti-inflammatory treatment for diabetic nephropathy and heart fibrosis. However, sFLT1 has also been related to peritubular capillary (PTC) loss, which promotes fibrogenesis. Here, we studied whether transfection with sFlt1 aggravates experimental AKI-to-CKD transition and whether sFLT1 is increased in human kidney fibrosis. (2) Methods: Mice were transfected via electroporation with sFlt1. After confirming transfection efficacy, mice underwent unilateral ischemia/reperfusion injury (IRI) and were sacrificed 28 days later. Kidney histology and RNA were analyzed to study renal fibrosis, PTC damage and inflammation. Renal sFLT1 mRNA expression was measured in CKD biopsies and control kidney tissue. (3) Results: sFlt1 transfection did not aggravate renal fibrosis, PTC loss or macrophage recruitment in IRI mice. In contrast, higher transfection efficiency was correlated with reduced expression of pro-fibrotic and pro-inflammatory markers. In the human samples, sFLT1 mRNA levels were similar in CKD and control kidneys and were not correlated with interstitial fibrosis or PTC loss. (4) Conclusion: As we previously found that sFLT1 has therapeutic potential in diabetic nephropathy, our findings indicate that sFLT1 can be administered at a dose that is therapeutically effective in reducing inflammation, without promoting maladaptive kidney damage.     

A bipolar membrane combined with ferric iron reduction as an efficient cathode system in microbial fuel cells

There is a need for alternative catalysts for oxygen reduction in the cathodic compartment of a microbial fuel cell (MFC). In this study, we show that a bipolar membrane combined with ferric iron reduction on a graphite electrode is an efficient cathode system in MFCs. A flat plate MFC with graphite felt electrodes, a volume of 1.2 L and a projected surface area of 290 cm2 was operated in continuous mode. Ferric iron was reduced to ferrous iron in the cathodic compartment according to Fe(3+) + e(-) --> Fe2+ (E0 = +0.77 V vs NHE, normal hydrogen electrode). This reversible electron transfer reaction considerably reduced the cathode overpotential. The low catholyte pH required to keep ferric iron soluble was maintained by using a bipolar membrane instead of the commonly used cation exchange membrane. For the MFC with cathodic ferric iron reduction, the maximum power density was 0.86 W/m2 at a current density of 4.5 A/m2. The Coulombic efficiency and energy recovery were 80-95% and 18-29% respectively.     

Application of bacteria involved in the biological sulfur cycle for paper mill effluent purification

In anaerobic wastewater treatment, the occurrence of biological sulfate reduction results in the formation of unwanted hydrogen sulfide, which is odorous, corrosive and toxic. In this paper, the role and application of bacteria in anaerobic and aerobic sulfur transformations are described and exemplified for the treatment of a paper mill wastewater. The sulfate containing wastewater first passes an anaerobic UASB reactor for bulk COD removal which is accompanied by the formation of biogas and hydrogen sulfide. In an aeration pond, the residual COD_organic and the formed dissolved hydrogen sulfide are removed. The biogas, consisting of CH₄ (80-90 vol.%), CO₂ (10-20 vol.%) and H₂S (0.8-1.2 vol.%), is desulfurised prior to its combustion in a power generator thereby using a new biological process for H₂S removal. This process will be described in more detail in this paper. Biomass from the anaerobic bioreactor has a compact granular structure and contains a diverse microbial community. Therefore, other anaerobic bioreactors throughout the world are inoculated with biomass from this UASB reactor. The sludge was also successfully used in investigation on sulfate reduction with carbon monoxide as the electron donor and the conversion of methanethiol. This shows the biotechnological potential of this complex reactor biomass.     

Quenched phosphorescence detection in cyclodextrin-based electrokinetic chromatography

Quenched phosphorescence detection is a sensitive detection method recently introduced in capillary zone electrophoresis. It is based on the dynamic quenching interaction of the analytes (quenchers) with a phosphorophore, 1-bromo-4-naphthalenesulfonate (BrNS), present in the separation buffer. In this study, it is shown that this detection method can also be used in cyclodextrin-based electrokinetic chromatography (CD-EKC) despite the presence in the buffer solution of cyclodextrins, which are known to reduce the luminescence quenching rate constants. Experiments indicate that BrNS mainly resides in the aqueous phase, while the analytes are distributed between both phases. In principle, the observed quenching might arise from the interaction of BrNS with uncomplexed as well as complexed analytes. However, from the dependence of the fractional quenching on the capacity factor (the normalized fractional quenching was found to be equal to the fraction of analyte in the aqueous phase), it was concluded that only aqueous-phase quenching contributes significantly to the observed quenching. Nevertheless, separation and detection can be regarded as fully compatible, because the capacity factors encountered in CD-EKC are generally low (in this study they ranged from about 0.1 to 2.5). Indeed, with nitroaromatic compounds as the target analytes, limits of detection in the 10(-8) M range were achieved.