Entry into force of the UN Watercourses Convention: why should it matter?

The United Nations Watercourses Convention entered into force on 17 August 2014, following a long and complex journey that dates back to 1970 when the UN referred the matter to its legal arm, the International Law Commission. This article follows the Convention through that long and turbulent road, examines its main provisions and analyses the reasons for the delay of its entry into force. It concludes by answering the question of why entry into force of the Convention should indeed matter.     

Superfluid-insulator transition in disordered boson systems

We review the localization problem in two dimensions for interacting bosons in a random potential. This problem is intimately related to the study of ⁴ He adsorbed in porous media, Josephson junction arrays, disordered superconducting films and vortex glasses. Using path integral Monte Carlo techniques, we find a superfluid, a localized or Bose glass insulator with gapless excitations, and (at commensurate densities) a Mott insulator with a finite gap to excitations.     

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools.     

Coupling granule properties and granulation rates in high-shear granulation

It is possible to link granulation rates to granule properties. The linkage is by multiple dimension population balance equations that, by means of simplifying assumptions, can be reduced to multiple one-dimensional (1-D) population balance equations (PBEs). Using simple physically based models, this paper demonstrates how multiple one-dimensional population balance equations can describe the results of high-shear granulation experiments of two different materials, calcium carbonate and lactose. Good agreement between experimental and simulated results was achieved enabling the granulation rates to be defined by two model parameters: the critical binder volume fraction and the aggregation rate constant. The modelling framework presented in this paper also provides a basis for the kinetic analysis of granulation experiments so that with further work, it is possible to determine the effect of process conditions and material properties on the model parameters.     

Non-uniformity of binder distribution in high-shear granulation

Further experimental investigation based on a microscopic, or single granule, scale has been conducted to investigate the uniformity of binder composition within a given size class for high shear melt granulation. This work assesses whether there is significant non-uniformity of binder composition within size classes to warrant considering this level of detail to improving population balance modelling of high shear granulation. It is concluded that at early times in a batch granulation process there is a broad variation in binder content between individual granules and that this variation persists in granules of small size.     

Quantum Inspired Broadband Photonic Absorber: Potential Application as Solar Sail along with Mobility Analysis

Electromagnetic wideband absorption is still perceived as a critical and formidable challenge to address with an unambiguous photonic absorber. Subwavelength metamaterial (MM) unit cells with unique and controlled features have recently gained considerable interest. However, meta-atoms, generated using a quantum-inspired pattern distribution, are underwhelming in existing literature to design photonic absorbers and their potential application to manufacture solar sails is still quite uncommon. In this article, to create a flexible, polarization-insensitive, ultrathin, and broadband MM absorber, quantum interference pattern-inspired design is utilized. Herein, a novel approach to fabricating solar sails for the space exploration incorporates the proposed broadband photonic absorber rather than conventional reflectors. The quantum-inspired meta-absorber (QIMA) exhibits an absorption of over 91% for the visible domain, i.e., 380–800 nm under a conventional plane-polarized source. It is shown in the study that broadband absorbers are almost equivalent to excellent reflectors to design the solar sails in terms of the time-averaged force calculated by utilizing the Maxwell stress tensor method. Thus, the QIMA has the potential to be a viable alternative to reflectors in the design of futuristic solar sails for space exploration. The interference theory model is also utilized to assure the dependability of calculated data, and additionally, the standard AM1.5 solar spectrum is utilized to demonstrate the QIMA's solar-harvesting potentiality.     

Efficient Body-Transfer Wheelchair for Assisting Functionally ImpairedPeople

Functionally impaired people always have difficulty accomplishing activities of daily living. In this regard, tasks including toileting and bathing have a higher prevalence rate of injuries and greater risk of falling. In this study, a body-transfer wheelchair was developed to assist people in transferring from bed to wheelchair for bathing, and toileting. The body-transfer wheelchair is a semi-automatic wheelchair that has features such as a controlled leg and backrest, linkage commode slot, and height adjustment. The wheelchair consists of a seat and a main frame that can be detached to enable bathtub transfer. This mechanism lets the user stay on the seat while being transferred into the bathtub without any risk of falling. A linkage mechanism was developed as a part of the seat for ease of toileting. Kinematic and force analysis was conducted to calculate the force required for each actuator. It has been proved by the experimental results that the wheelchair can securely and comfortably transfer a patient from the bed to the toilet or bathtub. A survey has been conducted to evaluate the wheelchair prototype design idea. Two focus groups were chosen: one comprised of functionally impaired people, and the other comprised of caregivers. The results of the survey show that 60% of both functionally impaired people and caregivers would like to use the body-transfer wheelchair for toileting and bathing purpose. Additionally, on average 65% of both focus groups find it convenient to operate the body-transfer wheelchair independently.     

Selective determination of urea using urease immobilized on ZnO nanowires

Well-aligned zinc oxide (ZnO) nanowire arrays were fabricated on gold-coated plastic substrates using a low-temperature aqueous chemical growth (ACG) method. The ZnO nanowire arrays with 50–130 nm diameters and ∼1 μm in lengths were used in an enzyme-based urea sensor through immobilization of the enzyme urease that was found to be sensitive to urea concentrations from 0.1 mM to 100 mM. Two linear sensitivity regions were observed when the electrochemical responses (EMF) of the sensors were plotted vs. the logarithmic concentration range of urea from 0.1 mM to 100 mM. The proposed sensor showed a sensitivity of 52.8 mV/decade for 0.1–40 mM urea and a fast response time less than 4 s was achieved with good selectivity, reproducibility and negligible response to common interferents such as ascorbic acid and uric acid, glucose, K⁺ and Na⁺ ions.