Performance engineering and topological design of metro WDM opticalnetworks using computer simulation

This paper demonstrates the use of computer simulation for topological design and performance engineering of transparent wavelength-division multiplexing metropolitan-area networks. Engineering of these networks involves the study of various transport-layer impairments such as amplifier noise, component ripple, chirp/dispersion, optical crosstalk, waveform distortion due to filter concatenation, fiber nonlinearities, and polarization effects. A computer simulation methodology composed of three main simulation steps is derived and implemented. This methodology obtains performance estimations by applying efficient wavelength-domain simulations on the entire network topology, followed by time-/frequency-domain simulations on selected paths of the network and finally Q-budgeting on an identified worst case path. The above technique provides an efficient tool for topological design and network performance engineering. Accurate simulation models are presented for each of the performance impairments, and the computer simulation methodology is used for the design and engineering of a number of actual metro network architectures     

Dynamic response and safety assessment of a batch process on cooling breakdown

Cooling breakdown in highly exothermic reaction processes may lead to runaway. The sensitivity and the safety assessment of a batch process on cooling breakdown are studied. The dependence of the minimum cooling time and the maximum allowable time of cooling breakdown for safe operation on the process parameters is investigated.     

Hand dexterity assessment based on mouse pointer trajectory measurements in children with learning disabilities

Universal Access in the Information Society - We present an investigation of the systematic differences in upper limb motor skills between children with learning disabilities (LDs) and children...     

A comparative study of important risk factors involved in offshore and domestic outsourcing of software development projects: A two-panel Delphi study

We investigated the risk factors of outsourced software development. Our first objective was to create empirically generated lists of risk factors for both domestically- and offshore-outsourced projects. Our second objective was to compare these two contexts: how do the risk factors change and which ones are most important in each. To address these objectives, we conducted two Delphi surveys to identify the important risk factors from a client perspective, in domestic and offshore settings. We qualitatively compared the results of the surveys to identify similarities and differences across their risk profiles. We identified three types of risks: those that appeared in both contexts; those that appeared in both but were exacerbated in the offshore context; and those that were unique to the offshore context. Our findings suggested that traditional project management risks were important in both contexts; however, the offshore context seemed to be more vulnerable to some traditional risks as well as factors that were unique to it.     

Improving the performance of passive network monitoring applications with memory locality enhancements

Passive network monitoring is the basis for a multitude of systems that support the robust, efficient, and secure operation of modern computer networks. Emerging network monitoring applications are more demanding in terms of memory and CPU resources due to the increasingly complex analysis operations that are performed on the inspected traffic. At the same time, as the traffic throughput in modern network links increases, the CPU time that can be devoted for processing each network packet decreases. This leads to a growing demand for more efficient passive network monitoring systems in which runtime performance becomes a critical issue.In this paper we present locality buffering, a novel approach for improving the runtime performance of a large class of CPU and memory intensive passive monitoring applications, such as intrusion detection systems, traffic characterization applications, and NetFlow export probes. Using locality buffering, captured packets are being reordered by clustering packets with the same port number before they are delivered to the monitoring application. This results in improved code and data locality, and consequently, in an overall increase in the packet processing throughput and decrease in the packet loss rate. We have implemented locality buffering within the widely used libpcap packet capturing library, which allows existing monitoring applications to transparently benefit from the reordered packet stream without modifications. Our experimental evaluation shows that locality buffering improves significantly the performance of popular applications, such as the Snort IDS, which exhibits a 21% increase in the packet processing throughput and is able to handle 67% higher traffic rates without dropping any packets.     

Conversion of a benign lymphoepithelial salivary gland lesion to lymphocytic lymphoma during dilantin therapy: correlation with dilantin-induced lymphocyte transformation in vitro

A patient with a classical salivary gland benign lymphoepithelial lesion (BLL) that converted to a lymphoblastic lymphoma (LSA) localized to the salivary glands is described. The malignant transformation of the BLL was preceded by Dilantin anticonvulsant therapy, and in vitro tests subsequent to the development of LSA demonstrated positive Dilantin-induced lymphocyte transformation. The lymphoma was treated successfully by local irradiation, chemotherapy, and discontinuation of Dilantin. The case illustrates the "prelymphomatous" nature of BLL in certain patients, as well as the possible potential danger of Dilantin and other lymphoid-stimulating drugs in discussed. Further study of drugs capable lymphocyte transformation in patients with prelymphomatous disorders is warranted.     

Decentralized optimality conditions of stochastic differential decision problems via Girsanov’s measure transformation

In this paper, we apply two methods to derive necessary and sufficient decentralized optimality conditions for stochastic differential decision problems with multiple Decision Makers (DMs), which aim at optimizing a common pay-off, based on the notions of decentralized global optimality and decentralized person-by-person (PbP) optimality. Method 1: We utilize the stochastic maximum principle to derive necessary and sufficient conditions which consist of forward and backward Stochastic Differential Equations (SDEs), and conditional variational Hamiltonians, conditioned on the information structures of the DMs. The sufficient conditions for decentralized PbP optimality are local conditions, closely related to the necessary conditions for decentralized PbP optimality. However, under certain convexity condition on the Hamiltonian, and a global version of the sufficient conditions for decentralized PbP optimality, we show decentralized global optimality. Method 2: We utilize the value processes of decentralized PbP optimal policies, we relate them to solutions of backward SDEs, we identify sufficient conditions for decentralized PbP optimality, and we show these are precisely those derived via the maximum principle. For both methods, as usual, we utilize Girsanov’s theorem to transform the initial decentralized stochastic optimal decision problems, to equivalent decentralized stochastic optimal decision problems on a reference probability space, in which the controlled process and the information processes which generate part of the information structures of the DMs, are independent of any of the decisions.     

Probing Protein Folding with Sequence-Reversed α-Helical Bundles

Recurrent protein folding motifs include various types of helical bundles formed by α-helices that supercoil around each other. While specific patterns of amino acid residues (heptad repeats) characterize the highly versatile folding motif of four-α-helical bundles, the significance of the polypeptide chain directionality is not sufficiently understood, although it determines sequence patterns, helical dipoles, and other parameters for the folding and oligomerization processes of bundles. To investigate directionality aspects in sequence-structure relationships, we reversed the amino acid sequences of two well-characterized, highly regular four-α-helical bundle proteins and studied the folding, oligomerization, and structural properties of the retro-proteins, using Circular Dichroism Spectroscopy (CD), Size Exclusion Chromatography combined with Multi-Angle Laser Light Scattering (SEC-MALS), and Small Angle X-ray Scattering (SAXS). The comparison of the parent proteins with their retro-counterparts reveals that while the α-helical character of the parents is affected to varying degrees by sequence reversal, the folding states, oligomerization propensities, structural stabilities, and shapes of the new molecules strongly depend on the characteristics of the heptad repeat patterns. The highest similarities between parent and retro-proteins are associated with the presence of uninterrupted heptad patterns in helical bundles sequences.     

Isotopic and Elemental Authenticity Markers: a Case Study on Cypriot Wines

This study monitors variations in isotopes and elements in relation to grape variety, environmental factors and provenance in order to address the wine authenticity issue. Inductively coupled plasma atomic emission spectroscopy (ICP-AES) assessed the wines’ elemental content. Site-specific nuclear isotope fractionation-nuclear magnetic resonance and isotope ratio mass spectrometry methodologies determined in authentic and commercial wines the distribution of the naturally occurring stable isotopes of the deuterium/hydrogen (D/H) ratios and carbon (¹³C/¹²C) in ethanol of wine and oxygen ratio (¹⁸O/¹⁶O) in wine water. Chemometrics delineated the elements and isotopes responsible for wine classification. Specifically, unsupervised principal component analysis (PCA) framed the importance of grape variety and provenance, while supervised analysis pinpointed the vineyard effect and highlighted the contribution of the vintage year. Validation steps ensured that the extracted models do not predict randomly and their results are reliable. In fact, the acquired results can be incorporated to the EU Wine Isotopic Databank database providing both a guide and a tool for eventual candidatures for denomination of origin and support both Cypriot wine and winemakers. In this context, this research contributes to authenticity assurance of wines and adds value to final products, while it helps controlling hazards arising from environmental changes.     

Solvothermal synthesis,nanostructural characterization and gas cryo-adsorption studies in a metal–organic framework (IRMOF-1) material

A nanoporous metal–organic framework material, exhibiting an IRMOF-1 type crystalline structure, was prepared by following a direct solvothermal synthesis approach, using zinc nitrate and terephthalic acid as precursors and dimethylformamide as solvent, combined with supercritical CO₂ activation and vacuum outgassing procedures. A series of advanced characterization methods were employed, including scanning electron microscopy, Fourier-transform infrared radiation spectroscopy and X-ray diffraction, in order to study the morphology, surface chemistry and structure of the IRMOF-1 material directly upon its synthesis. Porosity properties, such as Brunauer–Emmet–Teller (BET) specific area (～520 m²/g) and micropore volume (～0.2 cm³/g), were calculated for the activated sample based on N₂ gas sorption data collected at 77 K. The H₂ storage performance was preliminary assessed by low-pressure (0–1 bar) H₂ gas adsorption and desorption measurements at 77 K. The activated IRMOF-1 material of this study demonstrated a fully reversible H₂ sorption behavior combined with an adequate gravimetric H₂ uptake relative to its BET specific area, thus achieving a value of ～1 wt.% under close-to-atmospheric pressure conditions.