The grating coupling surface plasmon polariton (SPP) waveguide is designed for nanoparticle sensors applications, where the properties of SPP waveguide model such as grating length and grating space length are designed with the Matlab and Optiwave programs. The propagation vector β of SPP grating slot waveguide is evaluated, from which the sensor applications model are simulated by the finite difference time domain method. The effective permittivity of the nanoparticle solution is evaluated. The sensor models are selected and the effective permittivity of the nanoparticle solution and used in the simulation model. The sensor activity of waveguides is determined with various values of the permittivity of grating space. The simulation result shows that the surface plasmonic TM0 mode of the design model is depended on a resonance with input wavelength, period length, space length, number of the grating, the permittivity of grating space, and the nanoparticle concentration in grating space area. It shows that the cut off wavelength is shipped by the refractive index of grating space, while the result of simulation at some low IR wavelengths shows linear relative between Hy field intensity of TM0 mode and grating space refractive index. The graph between Hy field intensity and concentration of nanoparticle solution also shows a good linear function, which has the good potential for sensor applications.
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