A cooperative information system to support multi-expert systems development

The development of a multi-expert system (MES) is obviously a team project. This paper shows how database technology can actively and cooperatively support the development and design of a multi-expert system. The proposed solution is based on an Active and Deductive DataBase (ADDB). An extensional database records and maintains information about the project and its evolution. An intensional database, defined by a set of rules, coordinates and controls the activity of the different actors, and models relevant views on the project. This rule base can be fired automatically when an interesting event occurs and consequently either informs the members of the team concerned by this event (beginning of a new step, creation of a new product, modification of a knowledge base, etc.), or triggers another activity, or invokes other tools. This rule base can also be executed explicitly to provide its user (experts, developers, the project manager, etc.) with cooperative information concerning the project. This cooperative information improves the visibility and the intelligibility of the project and knowledge reuse.     

A model for foamed cementing of oil and gas wells

We present a two-dimensional model of the primary cementing process for foamed cement slurries. Foamed cement slurries have a number of claimed advantages, but also have a pressure-dependent density and rheology. The rheology is hard to quantify fully over all ranges of foam quality, which compromises the accuracy of models. The density variation is due to expansion/compression of the gas phase along the well, caused by variations in the static pressure. We show that in the absence of careful control, buoyancy-driven instabilities can result in the annulus, as the foamed slurry expands and the density drops below that of the displaced drilling mud. These instabilities appear to be of a classic porous media/Hele-Shaw cell fingering type, triggered by a threshold unstable density difference. We show that these instabilities are amplified by wellbore eccentricity, occurring lower in the well than in a concentric annulus. Our results question the safe usage of foamed cements in primary cementing.     

A generic approach to detect design patterns in model transformations using a string-matching algorithm

Software and Systems Modeling - Maintaining software artifacts is a complex and time-consuming task. Like any other program, model transformations are subject to maintenance. In a maintenance...     

Effect of adsorbed metal ions and buffer nature on IgG separation from human plasma by column chromatography using an ion exchange resin,Amberlite IRC‐718

Fractionation of human plasma on ion exchanger resin was performed on Amberlite IRC‐718 saturated with metal ions. Depletion of human immunoglobulin G was carried out by column chromatography using Tris‐HCl, pH 7 at different concentrations. Results showed that, when Cu⁺² and Ni⁺² were adsorbed on the resin, one or two fractions of purified IgG were obtained, respectively. Whereas Fe⁺² and Zn⁺², both retain IgG and serum albumin or serum albumin alone. Furthermore, the Ni⁺²‐resin retention of serum proteins is too strong that the use of 700 mMTris‐HCl cannot liberate any other proteins than nonadsorbed serum albumin. In conclusion, this investigation demonstrates that immobilized metal ion affinity chromatography with Cu²⁺, Ni²⁺, and Fe²⁺ immobilized on Amberlite IRC‐718 has the potential to be developed as part of a process to purify IgG out of untreated human plasma as acceptable adsorption and elution levels of IgG could be achieved. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010     

Protocol Moderators as Active Middle-Agents in Multi-Agent Systems

Interaction protocols are widely recognized as an essential mechanism for coordination within multi-agent systems. There is thus a need for coordination models for specifying, validating, and implementing protocols, possibly open and concurrent, efficiently and reliably. This paper proposes such a model, which considers protocols as resources and each conversation among agents following the rules of a protocol as a well-identified process. To this end, a new kind of middle-agent, called Moderator, is introduced. A Moderator is in charge of monitoring a conversation so that it progresses according to the protocol rules, and provides agents with services to ease their involvement in the conversation. This model fits the organization-centered view of multi-agent systems as it strictly distinguishes the agent-level and the organization-level concerns with regard to interaction. In addition, the paper shows that this model is supported by a High-Level Petri Net language that covers all the steps of protocol engineering: design, validation, implementation. This paper presents this Moderator Coordination Model along four related dimensions: a conceptual model of protocols, a MAS architecture, a suitable modeling formalism, and an associated development process.     

Lack of correlation between the effects of transient exposure to glutamate and those of hypoxia/reoxygenation in immature neurons in vitro

To assess the influence of brain immaturity on the effects of oxygen deprivation and the participation of excitotoxicity, the consequences of a 6-h exposure to either hypoxia (95% N2/5% CO2) or 100 microM glutamate were studied in cultured fetal rat forebrain neurons taken at two maturational stages, i.e., 6 and 13 days in vitro. Cells were examined for their morphology, viability, energy metabolism reflected by 2-D-[3H]deoxyglucose uptake, and protein synthesis assessed by [3H]leucine incorporation. Apoptosis and necrosis were scored using the fluorescent dye 4,6-diamidino-2-phenylindole. Whereas 6-day-old neurons responded to a 6-h hypoxia by transient hypermetabolism, biphasic increase in protein synthesis, and cycloheximide-sensitive apoptotic death within 72 h postexposure, glutamate did not affect cell characteristics by the same time. In 13-day-old neurons, hypoxia induced both apoptosis (8.2%) and necrosis (22.3%). At this age, glutamate definitely reduced energy metabolism (26%) and protein synthesis (17%) by the end of exposure. The percentage of necrotic neurons reached 40.7%, but the rate of apoptosis was unchanged compared with controls. Therefore, excitotoxicity cannot account for hypoxia-induced injury in immature neurons, but its participation is suggested in older cells by the suppression of the necrotic component of hypoxia by glutamate receptor antagonists at 13 days.     

Hibiscus cannabinus L. – Kenaf : A Review Paper

Kenaf (Hibiscus cannabinus L.) is a valuable fiber and medicinal plant from the Malvaceae family. It is an alternative crop that may be a feasible source of cellulose which is economically viable and ecologically friendly. This plant is cultivated for its fiber although its leaves and seeds have also been used in traditional medicine in India and Africa for the treatment of various disease conditions. Kenaf fibers are commonly used for paper pulp and cordage, but it is also a promising lignocellulosic feedstock for bioenergy production. The kenaf seed oil can be used for cooking and in different industrial applications. The present paper is an overview on its ethnobotanical and phytochemical properties reported in the literature that we have investigated and its great potential as a valuable multipurpose crop due to numerous uses.     

On finite damage: ductile fracture-damage evolution

The tensorial entities pertaining to the presence of a damage zone within a representative material sample are obtained from the micro-macro transition of kinematic quantities in finite deformation. It is shown that they reduce to a ‘small-damage’ tensor as the finite deformation measures reduce to their common infinitesimal counterpart.Based on an assumed local (microscopic) velocity field within a sample, the process of void growth from a spherical inclusion is then quantified by a tensorial damage evolution equation. This equation gives the rate of change of damage tensor as a function of the overall strain rate, actual damage state and some scale factor. The problem of oblate shape cavity growth in the direction of a higher (positive) overall strain component is examined.     

Biodegradable magnesium alloy coated with TiO2/MgO two-layer composite via magnetic sputtering for orthopedic applications: A study on the surface characterization,corrosion, and biocompatibility

In this study, a coating of thin TiO₂ layer and a TiO₂/MgO double layer were created on the surface of AZ91D alloy by magnetic sputtering method in order to improve the corrosion and biocompatibility properties of this alloy. The microstructural studies by field-emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) showed that coatings were formed continuously and homogeneously on the alloy surface. In the double-layer coating, MgTiO₃ and Mg₂TiO₄ compounds were formed at the coating/substrate interface in addition to TiO₂ and MgO phases as the main phases in the coating structure. The results of corrosion test showed that in general, coating improves the corrosion of AZ91D alloy in simulated-body fluid (SBF). The double-layer coating showed the best corrosion resistance at a corrosion current of 5.743 × 10^?7 μA/cm² and a corrosion potential of ?1.513 V due to its cathodic protection of the substrate and blockage of the path of the corrosive solution towards the substrate. In vitro tests showed that considering the good match between the used materials as the coating and body, no toxic material exits which results in improvement in biocompatibility, adhesion, and bone-cell multiplication.