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1.
Gianluca Selvaggio Claudine Chaouiya Florence Janody 《International journal of molecular sciences》2021,22(9)
The multistep development of cancer involves the cooperation between multiple molecular lesions, as well as complex interactions between cancer cells and the surrounding tumour microenvironment. The search for these synergistic interactions using experimental models made tremendous contributions to our understanding of oncogenesis. Yet, these approaches remain labour-intensive and challenging. To tackle such a hurdle, an integrative, multidisciplinary effort is required. In this article, we highlight the use of logical computational models, combined with experimental validations, as an effective approach to identify cooperative mechanisms and therapeutic strategies in the context of cancer biology. In silico models overcome limitations of reductionist approaches by capturing tumour complexity and by generating powerful testable hypotheses. We review representative examples of logical models reported in the literature and their validation. We then provide further analyses of our logical model of Epithelium to Mesenchymal Transition (EMT), searching for additional cooperative interactions involving inputs from the tumour microenvironment and gain of function mutations in NOTCH. 相似文献
2.
Kátia Cordeiro Mendonça Marc Olivier Abadie Claudine Béghein Patrice Blondeau 《Building Simulation》2014,7(5):489-501
The objective of this work is to evaluate the quality of the zonal airflow predictions compared to those provided by computational fluid dynamics (CFD) tools for an isothermal airflow induced in a room by a linear ceiling diffuser. This comparative analysis was conducted for a typical rectangular office designed for two people, considering two different arrangements of obstacles within the room volume. The ventilation was provided by a four-way ceiling diffuser type with large aspect ratio slots, the outlet integrated into it, operating in a three-way mode with slot Reynolds number of 2700. As a result, the airflow was transitional or weakly turbulent. The airflow patterns obtained with the zonal models were first compared qualitatively with the CFD computations. A quantitative comparison based on the mean velocities at the interface of the zonal grid was then carried out. The characteristic features of the zonal predictions are shown and the limitations of the zonal and CFD approaches are discussed. 相似文献
3.
Several neotropical leaf-beetles of the genus Platyphora ingest and specifically metabolize plant acquired pyrrolizidine alkaloids (PAs) of the lycopsamine type (e.g., rinderine or intermedine) and enrich the processed alkaloids in their exocrine defensive secretions. In contrast to the related palaearctic leaf beetles of the genus Oreina, which absorb and store only the non-toxic alkaloid N-oxides, Platyphora sequesters PAs exclusively as protoxic tertiary amines. In this study, the ability of P. boucardi larvae to accumulate PAs was investigated. Tracer studies with [14C]rinderine and its N-oxide revealed that P. boucardi larvae, like adult beetles, utilize the two alkaloidal forms with the same efficiency, but accumulate the alkaloid as a tertiary amine exclusively. Ingested rinderine is rapidly epimerized to intermedine, which is localized in the hemolymph and all other tissues; it is also detected on the larval surface. Like adults, larvae are able to synthesize their own alkaloid esters (beetle PAs) from orally administered [14C]retronecine and endogenous aliphatic 2-hydroxy acids. These retronecine esters show the same tissue distribution as intermedine. A long-term feeding experiment lasting for almost four months revealed that retronecine esters synthesized from [14C]retronecine in the larvae are transferred from larvae via pupae into the exocrine glands of adult beetles. Pupae contain ca. 45% of the labeled retronecine originally ingested, metabolized, and stored by larvae; ca. 12% of larval radioactivity could be recovered from the defensive secretions of adults sampled successively over two and a half months. Almost all of this radioactivity is found in the insect-made retronecine esters that are highly enriched in the defensive secretions, i.e., more than 200-fold higher concentration compared to pupae. 相似文献
4.
5.
A general formulation of the transport equation of solutes in porous media is developed theoretically for a slug injection, with the assumption that the distribution of the velocities in the medium is gaussian, and that molecular diffusion is negligible.The equivalent of the dispersion coefficient in the equation is then shown to be a function of time. Tracer experiments performed both in situ and in the lab seem to be in accordance with this hypothesis; as an example, this model is shown to give an excellent fit for the data published by Coats & al. in 1964, and for which these authors had developed the “dead end pore” model. 相似文献
6.
Sverine Gomes Nathalie Trannoy Philippe Grossel Franoise Depasse Claudine Bainier Daniel Charraut 《International Journal of Thermal Sciences》2001,40(11):1794
The used Scanning Thermal Microscopy (SThM) probe is a thin Pt resistance wire acting as a heat source and as a detector simultaneously. Its energetic balance is investigated by the study of the temperature profile along the probe. A theoretical approach of the measurement, based on this investigation, is then proposed. Simulations with this modelling are shown to predict how the heat, electrically produced in the probe, is dissipated in the probe-sample system. In particular, it is shown that the steady-state of conduction losses to the thermal element support varies versus the thermal conductivity of the sample and can lead to bad interpretations of the measurement. 相似文献
7.
Amina Meslem Aliou Dia Claudine Beghein Mouhammad El Hassan Ilinca Nastase Pierre-Jean Vialle 《Building and Environment》2011
The general context of the present study is the design of high induction HVAC air diffusers by means of passive jet control. When the diffuser is a perforated panel with lobed orifices (Meslem et al. 2010), the optimization of jet induction consists in improving the orifice’s geometry, the spacing between orifices and their arrangement on the panel. In this study, the flow field of a turbulent twin cross-shaped jet is investigated numerically using the standard k-ε model, the Shear Stress Transport (SST) k-ω model and the Reynolds Stress Model (RSM). The results are compared with PIV measurements. The objective is to assess their capability and limitations to predict the significant features of twin jet flow when the flow is numerically resolved through a lobed diffuser. It is shown that the k-ε and RSM models are more appropriate for predicting potential jet core length, the change in jet centreline streamwise velocity, and flow expansion in the symmetry plane of the twin jet flow. However, these models overestimate the overall flow expansion and the jet volumetric flow rate. The SST k-ω model seems more appropriate for the prediction of such dynamic integral quantities. A high level of turbulent kinetic energy predicted by the k-ε and RSM models in the near field of jets is probably the reason for this overestimation of jet induction. The SST k-ω model would appear to be the most appropriate tool for optimizing orifice design, orifice to orifice spacing and relative orifice orientation on a perforated panel diffuser. 相似文献
8.
Adrian Cerepi Claudine Durand Etienne Brosse 《Journal of Petroleum Science and Engineering》2002,35(3-4)
The objective of this work is to analyse the pore microgeometry and its effect on petrophysical properties in six low-resistivity sandstone reservoirs by combining a 2D quantitative petrographic image analysis (PIA) and 3D petrophysical tools. The classic petrophysical tools enable the measurement of different classic reservoir properties such as specific surface area, average pore diameter, pore size distribution, macroporosity and microporosity, capillary pressure versus saturation, pore chamber–pore throat diameter ratio, electrical properties and permeability. The petrographic image analysis quantifies pore microgeometry in more than four orders of magnitude, from submicron to millimeter scale. Chloritic low-resistivity sandstones show dual porosity structure defined as chloritic texture. The pore microgeometrical parameters measured by petrographic image analysis allow one to model different reservoir properties such as capillary pressure, permeability and electrical behaviour. The results obtained in these models show that pore microgeometry plays an important role in the physical properties of low-resistivity sandstone reservoirs. 相似文献
9.
Predicted that since the learning of complex responses is obstructed by anxiety, the degree of differentiation in the drawings of an adult should be inversely related to his neuroticism. This hypothesis was confirmed by a significant negative correlation between the scores obtained by 33 university students on the Eysenck Personality Inventory and their scores on a scale of differentiation in the drawing of a tree. Possible applications of these results to the field of creativity are discussed. (1 p ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
Claudine Houttemane Jean-Claude Boivin Daniel Thomas Michel Wozniak Guy Nowogrocki 《Materials Research Bulletin》1981,16(7):801-809
Copper(II) hydroxymethylphosphonate dihydrate HOCH2PO3Cu, 2 H2O is triclinic : a = 10.870(3), b = 5.130(2), , α = 96.6(1)β = 114.6(1), γ = 97.2(1)°, S.G. Pl?, Z = 2. The structure was solved by the heavy atom method and full matrix least-squares refinement to a final R value = 0.035. The two Cu atoms in the cell are structurally different : Cu(1) is octahedrally surrounded by four phosphonate oxygen atoms and two hydroxyl groups. Cu(1)O6 octahedra chains extend along [010]. Cu(2) is coordinated to two phosphonate oxygen atoms and four water molecules. Cu(2)O6 octahedra link the chains to form infinite layers parallel to [101]. These layers are held together by means of hydrogen bonds. The right formula must therefore be written [Cu(HOCH2PO3)2] Cu, 4 H2O. The greater stability of the octahedral configuration versus the t.b.p. one and the occurence of bonding between copper atoms and hydroxyl groups can explain the increase of stability observed from methylphosphonate to hydroxymethylphosphonate copper complexes. 相似文献