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1.
Agile software development methodologies are increasingly adopted by organizations because they focus on the client’s needs, thus safeguarding business value for the final product. At the same time, as the economy and society move toward globalization, more organizations shift to distributed development of software projects. From this perspective, while adopting agile techniques seems beneficial, there are still a number of challenges that need to be addressed; among these notable is the effective cooperation between the stakeholders and the geographically distributed development team. In addition, data collection and validation for requirements engineering demands efficient processing techniques in order to handle the volume of data as well as to manage different inconsistencies, when the data are collected using online tools. In this paper, we present “PBURC,” a patterns-based, unsupervised requirements clustering framework, which makes use of machine-learning methods for requirements validation, being able to overcome data inconsistencies and effectively determine appropriate requirements clusters for optimal definition of software development sprints. 相似文献
2.
Cleo C. L. van Aanhold Angela Koudijs Kyra L. Dijkstra Ron Wolterbeek Jan A. Bruijn Cees van Kooten Hans J. Baelde 《International journal of molecular sciences》2022,23(17)
(1) Background: Soluble Fms-like tyrosine kinase 1 (sFLT1) is an endogenous VEGF inhibitor. sFLT1 has been described as an anti-inflammatory treatment for diabetic nephropathy and heart fibrosis. However, sFLT1 has also been related to peritubular capillary (PTC) loss, which promotes fibrogenesis. Here, we studied whether transfection with sFlt1 aggravates experimental AKI-to-CKD transition and whether sFLT1 is increased in human kidney fibrosis. (2) Methods: Mice were transfected via electroporation with sFlt1. After confirming transfection efficacy, mice underwent unilateral ischemia/reperfusion injury (IRI) and were sacrificed 28 days later. Kidney histology and RNA were analyzed to study renal fibrosis, PTC damage and inflammation. Renal sFLT1 mRNA expression was measured in CKD biopsies and control kidney tissue. (3) Results: sFlt1 transfection did not aggravate renal fibrosis, PTC loss or macrophage recruitment in IRI mice. In contrast, higher transfection efficiency was correlated with reduced expression of pro-fibrotic and pro-inflammatory markers. In the human samples, sFLT1 mRNA levels were similar in CKD and control kidneys and were not correlated with interstitial fibrosis or PTC loss. (4) Conclusion: As we previously found that sFLT1 has therapeutic potential in diabetic nephropathy, our findings indicate that sFLT1 can be administered at a dose that is therapeutically effective in reducing inflammation, without promoting maladaptive kidney damage. 相似文献
3.
High prevalence of subclinical hypothyroidism and nodular thyroid disease in patients on hemodialysis
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Ana Beatriz B.A. Da Costa Caio Pellizzari Gisah A. Carvalho Beatriz C. Sant'Anna Rafaela L. Montenegro Roberto G. Zammar Filho Cleo O. Mesa Junior Patrícia R. Hauck Prante Marcia Olandoski Mauricio Carvalho 《Hemodialysis international. International Symposium on Home Hemodialysis》2016,20(1):31-37
Chronic kidney disease has been known to affect thyroid hormone metabolism. Low serum levels of T3 and T4 are the most remarkable laboratorial findings. A high incidence of goiter and nodules on thyroid ultrasonography has been reported in patients with end‐stage renal disease (ESRD). Our objective is to evaluate the prevalence of laboratorial and morphologic alterations in the thyroid gland in a cohort of patients with ESRD on hemodialysis (HD). Sixty‐one patients with ESRD on HD were selected and compared with 43 healthy subjects matched by age, gender, and weight. Patients were submitted to thyroid ultrasonography. T3, free T4 (FT4), thyroid‐stimulating hormone, antithyroglobulin, and antithyroperoxidase antibodies were measured. The mean age of patients with ESRD was 47.4 ± 12.3 and 61% were women. ESRD was mainly caused by hypertensive nephrosclerosis and diabetic nephropathy. Mean thyroid volume, as determined by ultrasonography, was similar in both groups. Patients with ESRD had more hypoechoic nodules when compared with the control group (24.1% vs. 7.9%, P = 0.056). Mean serum FT4 and T3 levels were significantly lower in patients with ESRD, and subclinical hypothyroidism was more prevalent in patients with ESRD (21.82% vs. 7.14% control group, P = 0.04). Titers of antithyroid antibodies were similar in both groups. ESRD was associated with a higher prevalence of subclinical hypothyroidism and lower levels of T3 and FT4. Almost a quarter of patients showed thyroid nodules >10 mm. Periodic ultrasound evaluation and assessment of thyroid function are recommended in patients with ESRD on HD. 相似文献
4.
Cleo Zanella Billa Jacques Wainer Claudia Barsottini 《Journal of Intelligent Information Systems》2011,36(1):49-72
This work presents the ST-Audit system that audits a patient record for conformance to a particular clinical guideline. The
system uses ST-Guide which models a guideline as a set of states and transitions. The audit system tries to find a path in
the state/transition diagram that corresponds to the actions taken by the physician, taking into consideration issues such
as the unavailability of all the data needed to evaluate the transitions. The system was used to audit an outpatient clinic
regarding their procedure for hypertension treatment (using the VI JNC guideline for hypertension), and the results of the
number of non-compliant actions were presented and discussed. A follow up auditing showed a small but statistically significant
reduction on the number of non-compliant actions for patients treated after the first audit. 相似文献
5.
Liu GL Rosa-Bauza YT Salisbury CM Craik C Ellman JA Chen FF Lee LP 《Journal of nanoscience and nanotechnology》2007,7(7):2323-2330
Real-time in situ detection of active proteases is crucial for early-stage cancer screening and cell signaling pathway study; however, it is difficult to achieve using fluorescence or radioactive probes at volumes below 1 nL. Here we demonstrated a hybrid optical probe by incorporating nanocrescent particle and peptides with artificial tag molecules. We performed a proof-of-concept study using prostate specific antigen (PSA), one of the most prominent prostate cancer markers, and a serine protease present in patients' seminal fluid and serum. The Raman spectral signal from the tag molecules is enhanced by the nanocrescent and the signal is monitored as the indicator for peptide cleavage in a femtoliter reaction volume, at levels close to a single proteolytically active PSA molecule. The high reaction specificity of the peptides on individual nanoparticles minimizes the false detection of other serine proteases and background Raman signal, which results in a high-fidelity and high-signal-to-noise-ratio cancer nanoprobe that can be easily incorporated into nano/microfluidic devices. 相似文献
6.
The main objective of this paper is to examine the effectiveness of computer-assisted formative assessment in a large, first-year undergraduate geography course. In particular, the paper evaluates the impact of computer-assisted multiple-choice practice tests on student performance in the course as well as student opinions of this type of formative assessment in two academic years (2008 and 2009). The multiple-choice questions included in the formative assessment vary in their level of difficulty and range from those that focus on knowledge and comprehension to those that focus on application and analysis. While the use of the computer-assisted practice tests is completely voluntary over 50 percent of students used them. Feedback questionnaires from both academic years reveals that students are overwhelmingly positive with over 95 percent indicating that the computer-assisted practice tests assist them in identifying their strengths and weaknesses and help them prepare for in-class midterms and final exams. Statistical analysis of in-class performance on midterms shows that students who use the computer-assisted practice quizzes earn significantly higher grades (i.e., equivalent to three letter grades) than those students who do not. The results of the research demonstrate that computer-assisted formative assessment (in this case practice tests) has a positive impact on student performance. 相似文献
7.
Aouni El-Hajje Elizabeth C. Kolos Jun Kit Wang Saeed Maleksaeedi Zeming He Florencia Edith Wiria Cleo Choong Andrew J. Ruys 《Journal of materials science. Materials in medicine》2014,25(11):2471-2480
The elastic modulus of metallic orthopaedic implants is typically 6–12 times greater than cortical bone, causing stress shielding: over time, bone atrophies through decreased mechanical strain, which can lead to fracture at the implantation site. Introducing pores into an implant will lower the modulus significantly. Three dimensional printing (3DP) is capable of producing parts with dual porosity features: micropores by process (residual pores from binder burnout) and macropores by design via a computer aided design model. Titanium was chosen due to its excellent biocompatibility, superior corrosion resistance, durability, osteointegration capability, relatively low elastic modulus, and high strength to weight ratio. The mechanical and physical properties of 3DP titanium were studied and compared to the properties of bone. The mechanical and physical properties were tailored by varying the binder (polyvinyl alcohol) content and the sintering temperature of the titanium samples. The fabricated titanium samples had a porosity of 32.2–53.4 % and a compressive modulus of 0.86–2.48 GPa, within the range of cancellous bone modulus. Other physical and mechanical properties were investigated including fracture strength, density, fracture toughness, hardness and surface roughness. The correlation between the porous 3DP titanium-bulk modulus ratio and porosity was also quantified. 相似文献
8.
Philip M. Jedrzejewski Ioscani Jimenez del Val Antony Constantinou Anne Dell Stuart M. Haslam Karen M. Polizzi Cleo Kontoravdi 《International journal of molecular sciences》2014,15(3):4492-4522
Glycoproteins represent the largest group of the growing number of biologically-derived medicines. The associated glycan structures and their distribution are known to have a large impact on pharmacokinetics. A modelling framework was developed to provide a link from the extracellular environment and its effect on intracellular metabolites to the distribution of glycans on the constant region of an antibody product. The main focus of this work is the mechanistic in silico reconstruction of the nucleotide sugar donor (NSD) metabolic network by means of 34 species mass balances and the saturation kinetics rates of the 60 metabolic reactions involved. NSDs are the co-substrates of the glycosylation process in the Golgi apparatus and their simulated dynamic intracellular concentration profiles were linked to an existing model describing the distribution of N-linked glycan structures of the antibody constant region. The modelling framework also describes the growth dynamics of the cell population by means of modified Monod kinetics. Simulation results match well to experimental data from a murine hybridoma cell line. The result is a modelling platform which is able to describe the product glycoform based on extracellular conditions. It represents a first step towards the in silico prediction of the glycoform of a biotherapeutic and provides a platform for the optimisation of bioprocess conditions with respect to product quality. 相似文献
9.
Direct introduction of phosphonate by the surface modification of polymers enhances biocompatibility
Cleo Choong Jon-Paul Griffiths Mark G. Moloney James Triffitt Diane Swallow 《Reactive and Functional Polymers》2009,69(2):77-85
A novel chemical method for the modification of polystyrene and nylon polymers by the reaction of diaryl carbenes permits the direct and efficient introduction of phosphonate residues upon the polymer surface. The method is simple to execute, involving solution coating to adsorb the reactive coating agent, followed by drying and thermolysis at temperatures not greater than 150 °C. This material can be further modified to the calcium phosphonate derivative, by treatment with aqueous calcium hydroxide. The modified polymers show enhanced biocompatibility of the modified polymer, as evidenced by the improved growth of MG63 human osteosarcoma cell line on the surface. This method is of significance since it offers a simple chemical protocol for the tailoring of the surface properties of materials, it avoids the need to construct ab initio new polymers for a given application, it provides an alternative to existing surface modification protocols, and it extends the range of polymers suitable as biocompatible materials . 相似文献
10.
The meanings of 18 verbal probability expressions were studied in 3 ways: (a) frequency distributions of what single number best represented each expression; (b) word-to-number acceptability functions from what range of numbers from 0% to 100% best represented each expression; and (c) number-to-word acceptability functions from which expressions were appropriate for multiples of 5% from 5% to 95%. These results agreed highly with others and were highly consistent across methods. Expressions incorporating the stem probable were quantitatively synonymous with expressions incorporating the stem likely. Except for expressions using the word chance, positive expressions (e.g., likely) were closer to 50% in meaning than corresponding negative expressions (e.g., unlikely). This method proved very useful in deriving fuzzy-set membership functions for probability words, encouraging us in our ongoing codification effort. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献