全文获取类型
收费全文 | 4934篇 |
免费 | 310篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 19篇 |
综合类 | 4篇 |
化学工业 | 1568篇 |
金属工艺 | 42篇 |
机械仪表 | 88篇 |
建筑科学 | 164篇 |
矿业工程 | 12篇 |
能源动力 | 83篇 |
轻工业 | 931篇 |
水利工程 | 52篇 |
石油天然气 | 17篇 |
无线电 | 180篇 |
一般工业技术 | 543篇 |
冶金工业 | 984篇 |
原子能技术 | 6篇 |
自动化技术 | 553篇 |
出版年
2024年 | 12篇 |
2023年 | 34篇 |
2022年 | 268篇 |
2021年 | 279篇 |
2020年 | 123篇 |
2019年 | 126篇 |
2018年 | 133篇 |
2017年 | 142篇 |
2016年 | 165篇 |
2015年 | 151篇 |
2014年 | 177篇 |
2013年 | 354篇 |
2012年 | 274篇 |
2011年 | 305篇 |
2010年 | 228篇 |
2009年 | 252篇 |
2008年 | 229篇 |
2007年 | 206篇 |
2006年 | 169篇 |
2005年 | 170篇 |
2004年 | 133篇 |
2003年 | 119篇 |
2002年 | 94篇 |
2001年 | 71篇 |
2000年 | 53篇 |
1999年 | 47篇 |
1998年 | 56篇 |
1997年 | 50篇 |
1996年 | 52篇 |
1995年 | 45篇 |
1994年 | 44篇 |
1993年 | 41篇 |
1992年 | 45篇 |
1991年 | 13篇 |
1990年 | 39篇 |
1989年 | 54篇 |
1988年 | 32篇 |
1987年 | 49篇 |
1986年 | 41篇 |
1985年 | 43篇 |
1984年 | 37篇 |
1983年 | 20篇 |
1982年 | 44篇 |
1981年 | 22篇 |
1980年 | 22篇 |
1979年 | 14篇 |
1978年 | 26篇 |
1977年 | 16篇 |
1975年 | 15篇 |
1974年 | 13篇 |
排序方式: 共有5246条查询结果,搜索用时 15 毫秒
1.
2.
Patricia Seoane-Collazo Amparo Romero-Pic Eva Rial-Pensado Laura Liares-Pose nxela Estvez-Salguero Johan Fern Rubn Nogueiras Carlos Diguez Miguel Lpez 《International journal of molecular sciences》2021,22(4)
Several studies have reported that nicotine, the main bioactive component of tobacco, exerts a marked negative energy balance. Apart from its anorectic action, nicotine also modulates energy expenditure, by regulating brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. These effects are mainly controlled at the central level by modulation of hypothalamic neuropeptide systems and energy sensors, such as AMP-activated protein kinase (AMPK). In this study, we aimed to investigate the kappa opioid receptor (κOR)/dynorphin signaling in the modulation of nicotine’s effects on energy balance. We found that body weight loss after nicotine treatment is associated with a down-regulation of the κOR endogenous ligand dynorphin precursor and with a marked reduction in κOR signaling and the p70 S6 kinase/ribosomal protein S6 (S6K/rpS6) pathway in the lateral hypothalamic area (LHA). The inhibition of these pathways by nicotine was completely blunted in κOR deficient mice, after central pharmacological blockade of κOR, and in rodents where κOR was genetically knocked down specifically in the LHA. Moreover, κOR-mediated nicotine effects on body weight do not depend on orexin. These data unravel a new central regulatory pathway modulating nicotine’s effects on energy balance. 相似文献
3.
Daniela Fogli Antonio Piccinno Stefan Carmien Gerhard Fischer 《Behaviour & Information Technology》2020,39(1):27-46
ABSTRACTThe digital age of the future is ‘not out there to be discovered’, but it needs to be ‘designed’. The design challenge has to address questions about how we want to live, work, and learn (as individuals and as communities) and what we value and appreciate, e.g.: reflecting on quality of life and creating inclusive societies. An overriding design trade-off for the digital age is whether new developments will increase the digital divide or will create more inclusive societies. Sustaining inclusive societies means allowing people of all ages and all abilities to exploit information technologies for personally meaningful activities. Meta-design fosters the design of socio-technical environments that end-user developers can modify and evolve at use time to improve their quality of life and favour their inclusion in the society. This paper describes three case studies in the domain of assistive technologies in which end users themselves cannot act as end-user developers, but someone else (e.g.: a caregiver or a clinician) must accept this role requiring multi-tiered architectures. The design trade-offs and requirements for meta-design identified in the context of the case studies and other researchers’ projects are described to inform the development of future socio-technical environments focused on social inclusion. 相似文献
4.
5.
6.
7.
Zhang Xi Wang Xianhai Zhao Hongke Ordóñez de Pablos Patricia Sun Yongqiang Xiong Hui 《Scientometrics》2019,119(3):1311-1344
Scientometrics - Altmetrics indices are increasingly applied to measure scholarly influence in recent years because they can reflect the influence of research outputs more timely comparing with... 相似文献
8.
9.
10.
Daniela Frasca Maria Romero Alain Diaz Denisse Garcia Seth Thaller Bonnie B. Blomberg 《International journal of molecular sciences》2021,22(4)
Senescent cells accumulate in the adipose tissue (AT) of individuals with obesity and secrete multiple factors that constitute the senescence-associated secretory phenotype (SASP). This paper aimed at the identification of B cells with a SASP phenotype in the AT, as compared to the peripheral blood, of individuals with obesity. Our results show increased expression of SASP markers in AT versus blood B cells, a phenotype associated with a hyper-metabolic profile necessary to support the increased immune activation of AT-derived B cells as compared to blood-derived B cells. This hyper-metabolic profile is needed for the secretion of the pro-inflammatory mediators (cytokines, chemokines, micro-RNAs) that fuel local and systemic inflammation. 相似文献