首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   499篇
  免费   45篇
  国内免费   2篇
电工技术   6篇
综合类   1篇
化学工业   162篇
金属工艺   10篇
机械仪表   12篇
建筑科学   23篇
矿业工程   5篇
能源动力   13篇
轻工业   76篇
水利工程   2篇
石油天然气   7篇
无线电   54篇
一般工业技术   69篇
冶金工业   37篇
原子能技术   6篇
自动化技术   63篇
  2024年   3篇
  2023年   10篇
  2022年   30篇
  2021年   35篇
  2020年   24篇
  2019年   14篇
  2018年   33篇
  2017年   19篇
  2016年   26篇
  2015年   19篇
  2014年   13篇
  2013年   31篇
  2012年   21篇
  2011年   24篇
  2010年   22篇
  2009年   25篇
  2008年   18篇
  2007年   21篇
  2006年   23篇
  2005年   13篇
  2004年   15篇
  2003年   16篇
  2002年   11篇
  2001年   7篇
  2000年   1篇
  1999年   7篇
  1998年   7篇
  1997年   3篇
  1996年   11篇
  1995年   4篇
  1994年   7篇
  1993年   1篇
  1992年   1篇
  1991年   4篇
  1990年   2篇
  1989年   4篇
  1987年   2篇
  1986年   1篇
  1985年   2篇
  1984年   1篇
  1983年   3篇
  1982年   1篇
  1981年   2篇
  1980年   3篇
  1978年   1篇
  1976年   2篇
  1973年   1篇
  1972年   1篇
  1967年   1篇
排序方式: 共有546条查询结果,搜索用时 15 毫秒
1.
2.
Treating neuroinflammation-related injuries and disorders through manipulation of neuroinflammation functions is being heralded as a new therapeutic strategy. In this study, a novel pectic galactan (PG) polysaccharide based gene therapy approach is developed for targeting reactive gliosis in neuroinflammation. Galectin-3 (Gal-3) is a cell protein with a high affinity to β-galactoside sugars and is highly expressed in reactive gliosis. Since PG carries galactans, it can target reactive gliosis via specific carbohydrate interaction between galactan and Gal-3 on the cell membrane, and therefore can be utilized as a carrier for delivering genes to these cells. The carrier is synthesized by modifying quaternary ammonium groups on the PG. The resulting quaternized PG (QPG) is found to form complexes with plasmid DNA with a mean diameter of 100 nm and have the characteristics required for targeted gene therapy. The complexes efficiently condense large amounts of plasmid per particle and successfully bind to Gal-3. The in vivo study shows that the complexes are biocompatible and safe for administration and can selectively transfect reactive glial cells of an induced cortical lesion. The results confirm that this PG-based delivery system is a promising platform for targeting Gal-3 overexpressing neuroinflammation cells for treating neuroinflammation-related injuries and neurodegenerative diseases.  相似文献   
3.
The requirements on an object-oriented DBMS for management of information in a large, complex enterprise are presented. These requirements aid in the achievement of an environment characterized by data sharing, open architectures, application and data portability, and assurance of data integrity. They were defined from the point of view of a user of the DBMS; therefore they describe the expected functionality of the DBMS and do not specify the method of implementation to achieve this functionality. They encompass requirements on the data model, query and data manipulation languages, the system architecure, interfaces to the system, change management, and transaction management.  相似文献   
4.
Marital discord and depressive symptomatology have repeatedly been found to be associated, but little is known about variables that influence this relationship. Data were collected from 139 couples seeking marital therapy, and analyses were conducted separately by gender. For wives, lower problem-solving ability, physical aggression by the partner, and 1 relationship belief predicted depressive symptomatology after the variance due to marital discord was removed in regression analyses. In addition to these predictors, less spouse-specific assertiveness, unemployment, and 1 other relationship belief were associated with depressive symptomatology for women after the variance due to marital discord was removed in partial correlation analyses. For men, only lower problem-solving ability added to the prediction of depressive symptomatology. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
5.
Lentils, rice and their blend (Koshary) were cooked by traditional Egyptian methods. Cooking resulted in slight changes in the total nitrogen, as well as in the non-protein nitrogen (NPN), ether extract and crude fibre of the three products, compared with raw grains. In contrast, significant decreases were found in the mineral elements, indicating losses through leaching, on washing and cooking. The mineral composition of lentils' cooking liquor confirmed this.  相似文献   
6.
SCADA (supervisory control and data acquisition) systems are used for controlling and monitoring industrial processes. We propose a methodology to systematically identify potential process-related threats in SCADA. Process-related threats take place when an attacker gains user access rights and performs actions, which look legitimate, but which are intended to disrupt the SCADA process. To detect such threats, we propose a semi-automated approach of log processing. We conduct experiments on a real-life water treatment facility. A preliminary case study suggests that our approach is effective in detecting anomalous events that might alter the regular process workflow.  相似文献   
7.
Infants' sensitivity to optical flow for controlling sitting and standing was tested using a "moving room" in which all of the walls moved together, or only the side walls or front wall moved. Two questions motivated this research. (a) is the optical flow necessary for inducing postural compensations spatially distributed in the optic array? (b) Do visually induced compensations follow a developmental progression, or alternatively, emerge all at once? Experiment 1 was designed to test postural compensations by 14-month-old infants capable of standing in the moving room. Experiment 2 was designed to test postural compensations by 5- to 9-month-old infants who were passively supported while sitting in the moving room. The results revealed that partial flow is generally sufficient for inducing postural compensations, but that the amplitude and consistency of the response depend on the location of the flow in the optic array. In addition, there was evidence suggesting that compensatory responses become increasingly systematic during the second half of the first year. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
8.
Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time.  相似文献   
9.
The radiationless relaxation of dicyanine A molecules in n-alcohols methanol to butanol has been studied by picosecond fluorescence spectroscopy and time-resolved nonlinear spectroscopy. The fluorescence decay rates have been measured as a function of viscosity, temperature, and fluorescence wavelength. It is shown that the wavelength dependence can be explained by coexistence of two ground-state conformers. The intrinsic activation barrier for the nonradiative decay from the excited surface is very small, much less than 1 kcal/mol. In a particular solvent the time constants of the nonradiative relaxation show a linear dependence on the variation of viscosity. The experimental data are discussed in relation to the BFO theory (Bagchi, B.; Fleming, G.R.; Oxtoby, D.W. J. Chem. Phys. 1983, 78: 7375).  相似文献   
10.
Following calls to advance the integration of risk and business process modeling paradigms, this paper formalizes the process of incorporating risk into business process models through the principles of Value-Focused Process Engineering (VFPE). In doing so, the paper aims to extend the existing VFPE modeling notation to reflect a set of necessary constructs required to adequately represent risk in goal-oriented business-process models. The extended set of constructs is proposed to support a formal systems view of process-based risk. Process-based risk is formalized on the one hand, as a product of complex interactions between activity-based elements, and on the other hand, as a natural component of the value creation mechanism of an elementary function or a complex process. The proposed risk-aware VFPE formalism also formulates rules for decomposing risk in process models according to the organizational values, thereby enabling better risk visibility, reducing process complexity, and ensuring continuity of business processes.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号