Discipline-based instruction to promote interdisciplinary design of wearable and pervasive computing products

This paper reports on a design experience for undergraduates in computer engineering, industrial design, and marketing that focuses on pervasive computing devices. Across a broad range of targeted application areas and user groups, many of the student designs have been wearable computers. Consequently, our course will be of interest to the wearable computing community, particularly in terms of our aim of bridging the gap between design and engineering. For the two most recent offerings of the course, we have utilized external observers and surveyed the students in order to validate the impact of aspects of our process and changes to it. This paper is based upon 5 years of experience and 2 years of analysis of our course, and it presents an overview of our process with both qualitative and quantitative results from these two most recent offerings.     

Anticipating Cutoff Diameters in Deterministic Lateral Displacement (DLD) Microfluidic Devices for an Optimized Particle Separation

Deterministic lateral displacement (DLD) devices enable to separate nanometer to micrometer‐sized particles around a cutoff diameter, during their transport through a microfluidic channel with slanted rows of pillars. In order to design appropriate DLD geometries for specific separation sizes, robust models are required to anticipate the value of the cutoff diameter. So far, the proposed models result in a single cutoff diameter for a given DLD geometry. This paper shows that the cutoff diameter actually varies along the DLD channel, especially in narrow pillar arrays. Experimental and numerical results reveal that the variation of the cutoff diameter is induced by boundary effects at the channel side walls, called the wall effect. The wall effect generates unexpected particle trajectories that may compromise the separation efficiency. In order to anticipate the wall effect when designing DLD devices, a predictive model is proposed in this work and has been validated experimentally. In addition to the usual geometrical parameters, a new parameter, the number of pillars in the channel cross dimension, is considered in this model to investigate its influence on the particle trajectories.     

Groundwater Exploitation and Its Impact on the Environment in the North China Plain

Abstract

The North China Plain (NCP) is one of China's most important social, economic, and agricultural regions. Currently, the Plain has 17,950 thousand ha of cultivated land, 71.1 percent of which is irrigated, consuming more than 70 percent of the total water supply. Increasing water demands associated with rapid urban and industrial development and expansion of irrigated land have led to overexploitation of both surface and the ratio of groundwater resources, particularly north of the Yellow River. In 1993, the ratio of groundwater exploitation to recharge in many parts of the NCP exceeded 1.0; in some areas, the ratio exceeded 1.5. Consequently, about 1.06 million ha of water-short irrigated areas in the NCP also have poor water quality. Persistent groundwater overexploitation in the northern parts of the NCP has resulted in water-level declines in both shallow and deep aquifers. According to data from 600 shallow groundwater observation wells in the Hebei Plain, the average depth to water increased from 7.23 m in 1983 to 11.52 m in 1993, indicating an average water-table decline of 0.425 m/year. Water table declines are not uniformly distributed throughout the area. Depletion rates are generally greatest beneath cities and intensively groundwater-irrigated areas. Water-table declines have also varied over time. With the continued decline of groundwater levels, large depression cones have formed both in unconfined and confined aquifers beneath the Hebei Plain. Groundwater depletion in the NCP has severely impacted the environment. Large tracts of land that overlie cones of depression have subsided, seawater has intruded into previously freshwater aquifers in coastal plains, and ground-water quality has deteriorated due to salinization, seawater intrusion, and untreated urban and industrial wastewater discharge. In order to balance groundwater exploitation with recharge, the major remedial measures suggested are to strengthen groundwater management, to raise water use efficiency, to adjust the water-consumed structure, and to increase water supply     

Ego development and chronic illness in adolescents.

To examine the effects of chronic illness on the psychological growth process known as ego development, scores were compared on the Sentence Completion Test for 36 teens (16 boys, 20 girls) with chronic illness and 50 teens (16 boys, 34 girls) without chronic illness. Their ages ranged from 13 to 21 years, with a mean of 17.4 years. Most were Black (37%) or Hispanic (41%) and lived in poor or working-class neighborhoods. When age, sex, and Peabody Picture Vocabulary Test (PPVT) scores were controlled in multiple regression analyses, no direct association between ego development stage and presence of chronic illness, severity of illness, age at onset, or duration of illness was found. Analysis of the chronically ill group alone revealed a significant PPVT?×?Severity interaction, indicating that ego development in chronically ill teens is lower when illness is more severe and verbal IQ is higher. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Removal of histone tails from nucleosome dissects the physical mechanisms of salt-induced aggregation,linker histone H1-induced compaction,and 30-nm fiber formation of the nucleosome array

In order to reveal the roles of histone tails in the formation of higher-order chromatin structures, we employed atomic force microscopy (AFM), and an in vitro reconstitution system to examine the properties of reconstituted chromatin composed of tail-less histones and a long DNA (106-kb plasmid) template. The tail-less nucleosomes did not aggregate at high salt concentrations or with an excess amount of core histones, in contrast with the behavior of nucleosomal arrays composed of nucleosomes containing normal, N-terminal tails. Analysis of our nucleosome distributions reveals that the attractive interaction between tail-less nucleosomes is weakened. Addition of linker histone H1 into the tail-less nucleosomal array failed to promote the formation of 30 nm chromatin fibers that are usually formed in the normal nucleosomal array. These results demonstrate that the attractive interaction between nucleosomes via histone tails plays a critical role in the formation of the uniform 30-nm chromatin fiber.     

In-house validation of an ELISA method for screening of semicarbazide in eggs

An enzyme-linked immunosorbent assay (ELISA) method is described for the semi-quantitative determination of semicarbazide (SEM), the marker residue for the banned nitrofuran drug, nitrofurazone, in chicken eggs. The sample homogenate is subjected to acid hydrolysis and derivatisation with o-nitrobenzaldehyde, followed by ethyl acetate/hexane extraction and detection by ELISA. The ELISA procedure has been validated using 0.3, 1.0 and 3 microg kg(-1) of SEM in fortified samples. Detection capability (CC(ss)) was based on the acceptance of 5% false compliant results for a given concentration level according to Commission Decision 2002/657/EC and was determined to be 0.3 microg kg(-1) with a respective limit of detection of 0.13 microg kg(-1). A validated LC-MS/MS method was used for the analysis of incurred egg samples and the results compared with ELISA. A good correlation between the results obtained from ELISA and LC-MS/MS within the concentration range 0.12-20.3 microg kg(-1) was observed in samples collected from chickens fed with a medicated ration of nitrofurazone (r = 0.992, n = 14). Validated ELISA enabled reliable monitoring of SEM levels in eggs collected from incurred chickens over a 90-day period.     

Identification of the Larval Aggregation Pheromone of Codling Moth, <Emphasis Type="Italic">Cydia pomonella</Emphasis>

Mature larvae of the codling moth, Cydia pomonella L. (Lepidoptera: Olethreutidae), exit the fruit and seek sites suitable for pupation. Spinning cocoons in such sites, larvae produce a complex, cocoon-derived blend of volatiles recently shown to attract and/or arrest both conspecific larvae and the prepupal parasitoid Mastrus ridibundus Gravenhorst (Hymenoptera: Ichneumonidae). Here we report components of this blend that constitute the pheromone of fifth-instar C. pomonella larvae. Thirty-one two-choice olfactometer experiments showed that a blend of synthetic (E)-2-octenal, (E)-2-nonenal, sulcatone, and geranylacetone, in combination with either 3-carene and/or three saturated aldehydes (octanal, nonanal, decanal), elicited behavioral responses from C. pomonella larvae. In on-tree experiments with corrugated cardboard bands as pupation sites for larvae affixed to tree trunks, and with laboratory-reared larvae released onto such trees, more larvae cocooned in those halves of cardboard bands baited with cocoon-spinning conspecific larvae, or with synthetic pheromone components, than in unbaited control halves of the bands. With the larval aggregation pheromone identified in this study, there might be an opportunity to manipulate C. pomonella larvae in commercial fruit or nut orchards.