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We analysed the ground deformation across two blocks defined by the Rio-Patras fault from 1993 to 2017 using multi-temporal Synthetic Aperture Radar Interferometry (InSAR) techniques. Our main objective was to contribute to the assessment of seismic hazard near the large city of Patras. Multiple data-sets were used, each one covering different temporal periods. Descending and ascending acquisitions, providing different viewing geometries contribute to fully determine the ground displacement in 3D. The data-sets used are from the European Space Agency’s (ESA) European Remote Sensing (ERS), Environmental Satellite (ENVISAT) and SENTINEL-1 as well as German Aerospace Center (DLR) ’s TERRASAR-X missions. Considering ESA’s missions covering both acquisition geometries and long periods, the southern block, showing lack of a sufficient number of scatterers does not allow the displacement characterization. In contrary, the northern block is characterized by a high number of scatterers having values of maximum likehood ranging from ?3.5 to ?4.3 mm year?1 for ascending geometry and from ?1.6 to ?2.7 mm year?1 for the descending one. The fact that both geometries show negative values of displacements are consistent with downlift movement and at the same time the quantitative differentiation probably indicates an horizontal component as well.  相似文献   
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Tumor progression to a metastatic and ultimately lethal stage relies on a tumor-supporting microenvironment that is generated by reciprocal communication between tumor and stromal host cells. The tumor–stroma crosstalk is instructed by the genetic alterations of the tumor cells—the most frequent being mutations in the gene Tumor protein p53 (TP53) that are clinically correlated with metastasis, drug resistance and poor patient survival. The crucial mediators of tumor–stroma communication are tumor-derived extracellular vesicles (EVs), in particular exosomes, which operate both locally within the primary tumor and in distant organs, at pre-metastatic niches as the future sites of metastasis. Here, we review how wild-type and mutant p53 proteins control the secretion, size, and especially the RNA and protein cargo of tumor-derived EVs. We highlight how EVs extend the cell-autonomous tumor suppressive activity of wild-type p53 into the tumor microenvironment (TME), and how mutant p53 proteins switch EVs into oncogenic messengers that reprogram tumor–host communication within the entire organism so as to promote metastatic tumor cell dissemination.  相似文献   
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This work concerns the micromechanical constitutive modelling, algorithmic implementation and numerical simulation of polycrystalline superelastic alloys under multiaxial loading. The model is formulated in finite deformations and incorporates the effect of texture. The numerical implementation is based on the constrained minimization of the Helmholtz free energy with dissipation. Simulations are conducted for thin tubes of Nitinol under tension–torsion, as well as for a simplified model of a biomedical stent. Copyright © 2004 John Wiley & Sons, Ltd.  相似文献   
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Robot Pose Estimation in Unknown Environments by Matching 2D Range Scans   总被引:14,自引:0,他引:14  
A mobile robot exploring an unknown environment has no absolute frame of reference for its position, other than features it detects through its sensors. Using distinguishable landmarks is one possible approach, but it requires solving the object recognition problem. In particular, when the robot uses two-dimensional laser range scans for localization, it is difficult to accurately detect and localize landmarks in the environment (such as corners and occlusions) from the range scans.In this paper, we develop two new iterative algorithms to register a range scan to a previous scan so as to compute relative robot positions in an unknown environment, that avoid the above problems. The first algorithm is based on matching data points with tangent directions in two scans and minimizing a distance function in order to solve the displacement between the scans. The second algorithm establishes correspondences between points in the two scans and then solves the point-to-point least-squares problem to compute the relative pose of the two scans. Our methods work in curved environments and can handle partial occlusions by rejecting outliers.  相似文献   
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Contents The control-canonical-form (CCF) method is introduced for the purpose of applying it to high-order state-space single-input single or multiple-output (SISO or SIMO) and multiple-input multiple-output (MIMO) linear time-invariant system models to determine closed-loop systems (i.e. design robust controllers) from which enchanced dynamic stability characteristics and overall performance of these systems is achieved. The method has been applied successfully to a SISO 6th-order linearized state-space open-loop model (representing a simplified hydro power system), and to a MIMO 8th-order linearized state-space open-loop model (representing an 87.5 kVA synchronous machine with conventional exciter supplying power to an electric utility system through an interconnection network)
Anwendung der kanonischen Form der Zustandsrückführung auf Erzeugersysteme zur Verbesserung der dynamischen Stabilitätseigenschaften
Übersicht Die Methode der kanonischen Form wird auf lineare zeitinvariante Systeme höherer Ordnung im Zustandsraum angewendet, die eine oder mehrere Eingangsgrößen bei einer oder mehreren Ausgangsgrößen aufweisen. Damit werden robuste Regler entworfen, welche die dynamische Stabilität und das gesamte Betriebsverhalten verbessern. Die Methode wurde erfolgreich auf ein linearisiertes Modell sechster Ordnung mit einem Eingang und einem Ausgang angewendet, das vereinfachend eine Wasserkraftanlage darstellt; außerdem auf ein linearisiertes Zustandsmodell achter Ordnung einer Synchronmaschine 87,5kVA mit konventioneller Erregung, die über ein Verbindungsnetzwerk in das öffentliche Netz einspeist.
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Improving Awareness in Mobile CSCW   总被引:1,自引:0,他引:1  
The diffusion of mobile devices in the working landscape is promoting collaboration across time and space. Following through this development, we investigate opportunities for improving awareness in mobile environments with a view to enable collaboration under power constraints and transitory network disconnections. We elaborate in particular on synchronous CSCW and expose with it significant details of group awareness, while we contribute a protocol for awareness support over large areas that strikes a balance between energy consumption and notification time. To avoid user disruption, this protocol notifies awareness information in a multicast fashion, while the bandwidth is allocated dynamically among notifications and data requests, thus minimizing the time needed by each one of them and ensuring the isochronous delivery of information to all clients. The efficiency and scalability of our protocol are evaluated with simulation experiments, whereby we compare various notification schemes and finally choose one that changes dynamically over time.  相似文献   
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