Extracellular Vesicles and Asthma—More Than Just a Co-Existence

Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma.     

Automatic Channel Detection Using DNN on 2D Seismic Data

Geologists interpret seismic data to understand subsurface properties and subsequently to locate underground hydrocarbon resources. Channels are among the most important geological features interpreters analyze to locate petroleum reservoirs. However, manual channel picking is both time consuming and tedious. Moreover, similar to any other process dependent on human intervention, manual channel picking is error prone and inconsistent. To address these issues, automatic channel detection is both necessary and important for efficient and accurate seismic interpretation. Modern systems make use of real-time image processing techniques for different tasks. Automatic channel detection is a combination of different mathematical methods in digital image processing that can identify streaks within the images called channels that are important to the oil companies. In this paper, we propose an innovative automatic channel detection algorithm based on machine learning techniques. The new algorithm can identify channels in seismic data/images fully automatically and tremendously increases the efficiency and accuracy of the interpretation process. The algorithm uses deep neural network to train the classifier with both the channel and non-channel patches. We provide a field data example to demonstrate the performance of the new algorithm. The training phase gave a maximum accuracy of 84.6% for the classifier and it performed even better in the testing phase, giving a maximum accuracy of 90%.     

Corrosion and mechanical behavior of fusion bonded epoxy (FBE) in aqueous media

In recent years there have been many reported cases of corrosion failure in cement concrete pipelines. In the majority of cases, the failures have been attributed to rebar corrosion which is caused by the permeability of chloride from low resistivity soil and subsequent attack on a passive layer on an iron bar in the structure. As a possible alternative to cementitious materials, some organic coatings based on olefin, vinyl or epoxy-based polymers have been considered. However, due to a paucity of data on the behavior of these coatings in aqueous media— particularly product water—the possibility of their application in water transmission systems in the Kingdom has not been fully exploited. This paper deals with the studies carried out on the corrosion and mechanical behavior of fusion bonded epoxy (FBE) coating on steel in aqueous media which include product water, distilled water and saline water. The mechanical testings on coating include adhesion, bending and cathodic disbondment testings. The corrosion studies include immersion testing under static and dynamic conditions, autoclave tests and accelerated (salt-fog) tests. The analysis of results indicates chemical inertness of FBE coating in either of the aforementioned water used during testing, good adhesion and no damage to the coating during bending. Cathodic disbondment tests indicate that FBE coating sustains under cathodic protection (CP) conditions. In general, the results of mechanical and corrosion tests indicate that FBE is a promising material for internal coating on steel in water transmission systems.     

Performance tuning of glass fiber/epoxy composites through interfacial modification upon integrating with dendrimer functionalized graphene oxide

In this study, glass fiber/epoxy composites were interfacially tailored by introducing polyamidoamine (PAM) dendrimer functionalized graphene oxide (GO) into epoxy matrix. Two different composites each containing varying loading fraction (0.5, 1.0, and 1.5 wt%) of GO and GO-PAM were fabricated via hot press processing. Composites were evaluated for interlaminar shear strength (ILSS), dynamic mechanical properties and thermal conductivity. The inclusion of 1.5 wt% GO-PAM resulted ~57.3%, ~42.7%, and ~54% enhancement in ILSS, storage modulus and thermal conductivity, respectively. Almost, ~71% reduction in coefficient of thermal expansion was also observed at same GO-PAM loading. Moreover, higher glass transition temperature was observed with GO-PAM addition. GO-PAM substantially improved fiber/matrix interfacial adhesion, which was witnessed through scanning electron microscopy. The enhanced thermo-mechanical performance was attributed to interfacial covalent interactions engendered by ring opening reaction between epoxy and amine moieties of PAM dendrimers. These multiscale composites with extraordinary functional properties can outperform conventional counterparts with improved reliability and performance.     

Artificial Algae Optimization with Deep Belief Network Enabled Ransomware Detection in IoT Environment

The Internet of Things (IoT) has gained more popularity in research because of its large-scale challenges and implementation. But security was the main concern when witnessing the fast development in its applications and size. It was a dreary task to independently set security systems in every IoT gadget and upgrade them according to the newer threats. Additionally, machine learning (ML) techniques optimally use a colossal volume of data generated by IoT devices. Deep Learning (DL) related systems were modelled for attack detection in IoT. But the current security systems address restricted attacks and can be utilized outdated datasets for evaluations. This study develops an Artificial Algae Optimization Algorithm with Optimal Deep Belief Network (AAA-ODBN) Enabled Ransomware Detection in an IoT environment. The presented AAA-ODBN technique mainly intends to recognize and categorize ransomware in the IoT environment. The presented AAA-ODBN technique follows a three-stage process: feature selection, classification, and parameter tuning. In the first stage, the AAA-ODBN technique uses AAA based feature selection (AAA-FS) technique to elect feature subsets. Secondly, the AAA-ODBN technique employs the DBN model for ransomware detection. At last, the dragonfly algorithm (DFA) is utilized for the hyperparameter tuning of the DBN technique. A sequence of simulations is implemented to demonstrate the improved performance of the AAA-ODBN algorithm. The experimental values indicate the significant outcome of the AAA-ODBN model over other models.     

Performance analysis of an opportunistic multi‐user cognitive network with multiple primary users

Consider a multi‐user underlay cognitive network where multiple cognitive users concurrently share the spectrum with a primary network with multiple users. The channel between the secondary network is assumed to have independent but not identical Nakagami‐m fading. The interference channel between the secondary users (SUs) and the primary users is assumed to have Rayleigh fading. A power allocation based on the instantaneous channel state information is derived when a peak interference power constraint is imposed on the secondary network in addition to the limited peak transmit power of each SU. The uplink scenario is considered where a single SU is selected for transmission. This opportunistic selection depends on the transmission channel power gain and the interference channel power gain as well as the power allocation policy adopted at the users. Exact closed form expressions for the moment‐generating function, outage performance, symbol error rate performance, and the ergodic capacity are derived. Numerical results corroborate the derived analytical results. The performance is also studied in the asymptotic regimes, and the generalized diversity gain of this scheduling scheme is derived. It is shown that when the interference channel is deeply faded and the peak transmit power constraint is relaxed, the scheduling scheme achieves full diversity and that increasing the number of primary users does not impact the diversity order. Copyright © 2014 John Wiley & Sons, Ltd.     

Preliminary Structural Data Revealed That the SARS-CoV-2 B.1.617 Variant's RBD Binds to ACE2 Receptor Stronger Than the Wild Type to Enhance the Infectivity

The evolution of new SARS-CoV-2 variants around the globe has made the COVID-19 pandemic more worrisome, further pressuring the health care system and immunity. Novel variations that are unique to the receptor-binding motif (RBM) of the receptor-binding domain (RBD) spike glycoprotein, i. e. L452R-E484Q, may play a different role in the B.1.617 (also known as G/452R.V3) variant's pathogenicity and better survival compared to the wild type. Therefore, a thorough analysis is needed to understand the impact of these mutations on binding with host receptor (RBD) and to guide new therapeutics development. In this study, we used structural and biomolecular simulation techniques to explore the impact of specific mutations (L452R-E484Q) in the B.1.617 variant on the binding of RBD to the host receptor ACE2. Our analysis revealed that the B.1.617 variant possesses different dynamic behaviours by altering dynamic-stability, residual flexibility and structural compactness. Moreover, the new variant had altered the bonding network and structural-dynamics properties significantly. MM/GBSA technique was used, which further established the binding differences between the wild type and B.1.617 variant. In conclusion, this study provides a strong impetus to develop novel drugs against the new SARS-CoV-2 variants.     

A Smart English Text Zero-Watermarking Approach Based on Third-Level Order and Word Mechanism of Markov Model

Text information is principally dependent on the natural languages. Therefore, improving security and reliability of text information exchanged via internet network has become the most difficult challenge that researchers encounter. Content authentication and tampering detection of digital contents have become a major concern in the area of communication and information exchange via the Internet. In this paper, an intelligent text Zero-Watermarking approach SETZWMWMM (Smart English Text Zero-Watermarking Approach Based on Mid-Level Order and Word Mechanism of Markov Model) has been proposed for the content authentication and tampering detection of English text contents. The SETZWMWMM approach embeds and detects the watermark logically without altering the original English text document. Based on Hidden Markov Model (HMM), Third level order of word mechanism is used to analyze the interrelationship between contexts of given English texts. The extracted features are used as a watermark information and integrated with digital zero-watermarking techniques. To detect eventual tampering, SETZWMWMM has been implemented and validated with attacked English text. Experiments were performed on four datasets of varying lengths under multiple random locations of insertion, reorder and deletion attacks. The experimental results show that our method is more sensitive and efficient for all kinds of tampering attacks with high level accuracy of tampering detection than compared methods.     

Intelligent Deep Learning Model for Privacy Preserving IIoT on 6G Environment

In recent times, Industrial Internet of Things (IIoT) experiences a high risk of cyber attacks which needs to be resolved. Blockchain technology can be incorporated into IIoT system to help the entrepreneurs realize Industry 4.0 by overcoming such cyber attacks. Although blockchain-based IIoT network renders a significant support and meet the service requirements of next generation network, the performance arrived at, in existing studies still needs improvement. In this scenario, the current research paper develops a new Privacy-Preserving Blockchain with Deep Learning model for Industrial IoT (PPBDL-IIoT) on 6G environment. The proposed PPBDL-IIoT technique aims at identifying the existence of intrusions in network. Further, PPBDL-IIoT technique also involves the design of Chaos Game Optimization (CGO) with Bidirectional Gated Recurrent Neural Network (BiGRNN) technique for both detection and classification of intrusions in the network. Besides, CGO technique is applied to fine tune the hyperparameters in BiGRNN model. CGO algorithm is applied to optimally adjust the learning rate, epoch count, and weight decay so as to considerably improve the intrusion detection performance of BiGRNN model. Moreover, Blockchain enabled Integrity Check (BEIC) scheme is also introduced to avoid the misrouting attacks that tamper the OpenFlow rules of SDN-based IIoT system. The performance of the proposed PPBDL-IIoT methodology was validated using Industrial Control System Cyber-attack (ICSCA) dataset and the outcomes were analysed under various measures. The experimental results highlight the supremacy of the presented PPBDL-IIoT technique than the recent state-of-the-art techniques with the higher accuracy of 91.50%.     

Intelligent Biomedical Electrocardiogram Signal Processing for Cardiovascular Disease Diagnosis

Automatic biomedical signal recognition is an important process for several disease diagnoses. Particularly, Electrocardiogram (ECG) is commonly used to identify cardiovascular diseases. The professionals can determine the existence of cardiovascular diseases using the morphological patterns of the ECG signals. In order to raise the diagnostic accuracy and reduce the diagnostic time, automated computer aided diagnosis model is necessary. With the advancements of artificial intelligence (AI) techniques, large quantity of biomedical datasets can be easily examined for decision making. In this aspect, this paper presents an intelligent biomedical ECG signal processing (IBECG-SP) technique for CVD diagnosis. The proposed IBECG-SP technique examines the ECG signals for decision making. In addition, gated recurrent unit (GRU) model is used for the feature extraction of the ECG signals. Moreover, earthworm optimization (EWO) algorithm is utilized to optimally tune the hyperparameters of the GRU model. Lastly, softmax classifier is employed to allot appropriate class labels to the applied ECG signals. For examining the enhanced outcomes of the proposed IBECG-SP technique, an extensive simulation analysis take place on the PTB-XL database. The experimental results portrayed the supremacy of the IBECG-SP technique over the recent state of art techniques.