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Faithfull Alexander Bengtson Jesper Tassi Enrico Tankink Carst 《International Journal on Software Tools for Technology Transfer (STTT)》2018,20(2):125-137
International Journal on Software Tools for Technology Transfer - User interfaces for interactive proof assistants have always lagged behind those for mainstream programming languages. Whereas... 相似文献
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M Kleen O Habler J Hutter A Podtschaske M Tiede G Kemming M Welte PE Keipert S Batra NS Faithfull C Corso K Messmer 《Canadian Metallurgical Quarterly》1998,162(4):439-446
The neurotoxicity of dibucaine was compared with that of commercially available local anesthetics in studies using rabbit desheathed cervical vagus nerve preparation. Dibucaine dose-dependently suppressed the evoked action potential of myelinated A beta nerve component and nonmyelinated C nerve component. The potential of A beta nerve component was more strongly suppressed, compared with that of C nerve component. At low concentrations of 0.0001-0.001%, the suppression was reversible and recovery with C nerve component was faster and more complete. At higher concentrations, the suppression was irreversible. The minimum concentrations of irreversible blockade were 0.003% for A beta nerve component and 0.03% for C nerve component. Electron microscopically, marked damages in the myelin layer and intraaxonal structure were observed in nerves treated with 0.03% dibucaine. When the neurotoxic effect of dibucaine was compared, in terms of safety margins (minimum concentration of irreversible blockade/clinically used concentrations), with those of commercially available local anesthetics, the rank order was dibucaine, tetracaine and bupivacaine; dibucaine showing the lowest safety margin. 相似文献
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M Kleen O Habler J Hutter A Podtschaske M Tiede G Kemming C Corso S Batra P Keipert S Faithfull K Messmer 《Canadian Metallurgical Quarterly》1997,2(10):413-418
Perfusion of intestinal organs increases in response to acute normovolemic hemodilution (ANH). However, detailed studies on distribution of regional splanchnic organ perfusion during ANH are lacking. We therefore carried out this study to test the hypothesis that ANH does not cause disturbance of physiologic patterns of regional splanchnic organ blood flow. After governmental permission, 22 anesthetized dogs were instrumented to allow invasive hemodynamic measurements and intracardial injection of radioactive microspheres (diameter 15 micro m) for determination of regional organ perfusion. Measurements were made at baseline (hematocrit 37 +/- 3%) and after ANH with 6% hydroxyethyl starch (mol. wt. 200000 / 0.5) to hct 20 +/- 1%. After completion of the protocol, splanchnic organs were removed and dissected into small samples according to anatomical and functional principles. Regional perfusion was determined based on the microsphere content of each sample. Hepatic, intestinal, and pancreatic blood flow increased with ANH. Hepatic arterial blood flow rose by 86%, whereas portal venous perfusion increased by 28%. Small intestine mucosal perfusion was augmented by 68% while the non-mucosal tissue compartment of the gut wall received 32% more blood flow after ANH which is in proportion to the increase in cardiac index after ANH. This redistribution of intestinal flow might be the basis for the preservation of tissue oxygenation during moderate isovolemic anemia. 相似文献
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Nigel T. Faithfull 《Journal of the science of food and agriculture》1984,35(8):819-826
The origins and development of in-vitro techniques for the determination of the apparent digestibility of ruminant feedstuffs are critically reviewed. Special attention is given to the effect of the pH used for the pepsin digestion stage, its optimum value, and its solubilising effect upon various mineral compounds and protein- and mineral-tannin complexes formed in the ruminant digestive system. New experimental evidence is presented concerning the latter effect. Comparisons are made with the Tilley and Terry method in widespread use at the present time. 相似文献
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