An O(nlog n)-SPACE Decision Procedure for the Propositional Dummett Logic

We present a tableau calculus for propositional Dummett logic, also known as LC (Linear Chain), where the depth of the deductions is linearly bounded by the length of the formulas to be proved. We then show that it is possible to decide propositional Dummett logic in O(nlogn)-SPACE.     

Paraquat resistance and starvation conditions in the selection of longevity extremes in Drosophila melanogaster populations previously selected for long and short developmental period

This paper analyzes the interaction between resistance to free radicals, development under starvation conditions, sex, and its consequences to the lifespan of Drosophila melanogaster populations selected for developmental time and longevity. Our data suggest that the interaction between these physiological and environmental parameters is modulated largely by the pre-imaginal developmental time, since the response to selection for longevity extremes depends strongly on the previous selection for developmental time extremes.     

Genetic mapping of lung cancer modifier loci specifically affecting tumor initiation and progression

Mouse inbred strains with inherited predisposition and resistance to lung cancer provide a tool for the dissection of the complex genetics of this disease. In the present report, we have crossed the BALB/c with the SWR/J strain and performed whole-genome scanning for loci affecting lung tumor development in their F2 progeny. Both parental strains carry the pulmonary adenoma susceptibility 1 (Pas1) locus, a major locus affecting predisposition to lung cancer in mice. On distal chromosome 18 and on centromere of chromosome 6, we have mapped two pulmonary adenoma resistance loci (Par2 and Par4, respectively), which reduce lung tumor multiplicity strongly, up to 15-fold. Par2 and Par4, however, do not affect lung tumor size, which is instead controlled by an additional locus that we have mapped on the central region of chromosome 4. We designated this locus as "pulmonary adenoma progression 1" (Papg1), because it specifically modifies lung tumor size but not multiplicity. The present results, therefore, provide evidence for the existence of cancer modifier loci acting on specific stages of lung tumorigenesis.     

Sheathed cold-formed steel housing: A seismic design procedure

Nowadays, different research teams are engaged on experimental and theoretical studies having as main aim the evaluation of seismic performance of sheathed cold-formed steel frame structures. Although a relatively large number of experimental and theoretical studies are available, the development of useful tools for the seismic design should be improved. As an attempt to overcome this lack, this paper aims to present a structural design procedure that allows, through the definition of three design nomographs, the screw spacing and all the shear walls components to be obtained on the basis of linear dynamic or nonlinear static seismic analysis. In addition, a procedure for the prediction of the whole pushover response curve of sheathed cold-formed steel shear walls, which can be advantageously used for developing the design nomographs, is presented.     

Optimization techniques for propositional intuitionistic logic and their implementation

This paper presents some techniques which bound the proof search space in propositional intuitionistic logic. These techniques are justified by Kripke semantics and are the backbone of a tableau based theorem prover (PITP) implemented in C++. PITP and some known theorem provers are compared using the formulas of ILTP benchmark library. It turns out that PITP is, at the moment, the propositional prover that solves most formulas of the library.     

Antagonizing S1P3 Receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis

S1P is the final product of sphingolipid metabolism, which interacts with five widely expressed GPCRs (S1P_1-5). Increasing numbers of studies have indicated the importance of S1P₃ in various pathophysiological processes. Recently, we have identified a pepducin (compound KRX-725-II) acting as an S1P₃ receptor antagonist. Here, aiming to optimize the activity and selectivity profile of the described compound, we have synthesized a series of derivatives in which Tyr, in position 4, has been substituted with several natural aromatic and unnatural aromatic and non-aromatic amino acids. All the compounds were evaluated for their ability to inhibit vascular relaxation induced by KRX-725 (as S1P₃ selective pepducin agonist) and KRX-722 (an S1P₁-selective pepducin agonist). Those selective towards S1P₃ (compounds V and VII) were also evaluated for their ability to inhibit skeletal muscle fibrosis. Finally, molecular dynamics simulations were performed to derive information on the preferred conformations of selective and unselective antagonists.     

Contraction-Free Linear Depth Sequent Calculi for Intuitionistic Propositional Logic with the Subformula Property and Minimal Depth Counter-Models

In this paper we present LSJ, a contraction-free sequent calculus for Intuitionistic propositional logic whose proofs are linearly bounded in the length of the formula to be proved and satisfy the subformula property. We also introduce a sequent calculus RJ for intuitionistic unprovability with the same properties of LSJ. We show that from a refutation of RJ of a sequent σ we can extract a Kripke counter-model for σ. Finally, we provide a procedure that given a sequent σ returns either a proof of σ in LSJ or a refutation in RJ such that the extracted counter-model is of minimal depth.     

A technique to measure optical properties of brownout clouds for modeling terahertz propagation

Brownout, the loss of visibility caused by dust resultant of helicopter downwash, is a factor in the large majority of military helicopter accidents. As terahertz radiation readily propagates through the associated dust aerosols and is attenuated by atmospheric water vapor within short distances, it can provide low-profile imaging that improves effective pilot visibility. In order to model this application of terahertz imaging, it is necessary to determine the optical properties of obscurants at these frequencies. We present here a method of empirical calculation and experimental measurement of the complex refractive index of the obscuring aerosols. Results derived from terahertz time-domain spectral measurements are incorporated into the AFIT CDE Laser Environmental Effects Definition and Reference (LEEDR) software.     

Intraoperative monitoring of facial nerve antidromic potentials during acoustic neuroma surgery

The present paper presents monopolar recording of facial nerve antidromic potentials as an alternative technique to facial electromyography for the continuous monitoring of the facial nerve during acoustic neuroma surgery. The investigation involved 22 patients undergoing acoustic neuroma surgery via a retrosigmoid approach (tumour sizes ranging from 5 to 28 mm). Bipolar electrical stimulation of the marginalis mandibulae was performed to elicit facial nerve antidromic potentials. Stimulus intensity ranged from 2 to 6 mA with a delivery rate of 7/sec. A silver wire monopolar electrode positioned intracranially on the proximal portion of the acoustic facial bundle was used to record antidromic potentials. To define the specific origin of the action potentials and acquire normative data, monopolar and bipolar recordings of facial nerve antidromic potentials were performed in 15 subjects undergoing retrosigmoid vestibular neurectomy for Meniere's disease. The average facial nerve antidromic potential latency was 4.2 (+/- 0.6) msec in subjects with acoustic neuroma and 3.3 (+/- 0.2) msec in subjects with Meniere's disease. Facial nerve antidromic potentials furnished near real-time information about intraoperative facial nerve damage and postoperative facial nerve function during acoustic neuroma surgery. Facial nerve antidromic potentials may provide additional information to conventional EMG. They allow the use of endplate blockers, yield quantitative estimation of facial nerve conduction properties in terms of amplitude and latency, and allow actual continuous monitoring of the facial nerve.     

Paraproteinemia, plasmacytoma, myeloma and HIV infection

We have identified by MEDLINE search the cases of gammaglobinopathy and plasma cell malignancy in HIV-positive patients reported in the English language literature. The average age at presentation among HIV-positive patients with plasma cell disorders is 33 years, far younger than the average age of presentation in the general population. Some of these patients present with transient paraproteinemias, while others have persistent paraproteins, which may or may not be associated with true plasma cell malignancies. In most cases in which it has been examined, the paraprotein contains high-titer anti-HIV activity. The presence of high-titer anti-HIV activity in the paraproteins of AIDS patients suggests that an antigen-driven process in response to HIV infection may contribute to the early development of plasma cell disorders in these patients. Recent work in plasma cell tumorigenesis has indicated that transformation at a single point in the B lymphocyte lineage can give rise to either lymphoma or myeloma, dependent upon environmental factors such as T cell function, which may be required for directing transformed lymphocytes from lymphoma and towards plasma cell differentiation. This may explain why B lineage oncogenesis in AIDS patients favors the development of lymphoma over that of myeloma.