Efficient driver drowsiness detection at moderate levels of drowsiness

Previous research on driver drowsiness detection has focused primarily on lane deviation metrics and high levels of fatigue. The present research sought to develop a method for detecting driver drowsiness at more moderate levels of fatigue, well before accident risk is imminent. Eighty-seven different driver drowsiness detection metrics proposed in the literature were evaluated in two simulated shift work studies with high-fidelity simulator driving in a controlled laboratory environment. Twenty-nine participants were subjected to a night shift condition, which resulted in moderate levels of fatigue; 12 participants were in a day shift condition, which served as control. Ten simulated work days in the study design each included four 30-min driving sessions, during which participants drove a standardized scenario of rural highways. Ten straight and uneventful road segments in each driving session were designated to extract the 87 different driving metrics being evaluated. The dimensionality of the overall data set across all participants, all driving sessions and all road segments was reduced with principal component analysis, which revealed that there were two dominant dimensions: measures of steering wheel variability and measures of lateral lane position variability. The latter correlated most with an independent measure of fatigue, namely performance on a psychomotor vigilance test administered prior to each drive. We replicated our findings across eight curved road segments used for validation in each driving session. Furthermore, we showed that lateral lane position variability could be derived from measured changes in steering wheel angle through a transfer function, reflecting how steering wheel movements change vehicle heading in accordance with the forces acting on the vehicle and the road. This is important given that traditional video-based lane tracking technology is prone to data loss when lane markers are missing, when weather conditions are bad, or in darkness. Our research findings indicated that steering wheel variability provides a basis for developing a cost-effective and easy-to-install alternative technology for in-vehicle driver drowsiness detection at moderate levels of fatigue.     

Conformation of polymer molecules at solid-liquid interfaces by small-angle neutron scattering

A wide variety of physical-chemical phenomena depend on the behavior of the polymer at solid-liquid interfaces. The feature that distinguishes such phenomena from their small-molecule counterparts is the long-chain structure of the polymer molecules. Just as in solution and the bulk, the conformational statistics of the polymer molecules in the interface is an important determinant of interfacial properties. Conformational statistics of interfacial polymer is expressed in terms a function called the polymer density profile ϕ(Z), which is just the volume fraction of polymer as a function of Z, the distance from the solid surface out into the continuum liquid. There is only one experimental technique that is purported to be able to determine polymer density profiles of polymers confined to the interface between finely divided substrate and dispersant, and that technique is small-angle neutron scattering (SANS). In this paper we present a protocol for the analysis of SANS data on spherical particles with adsorbed polymer for the determination of ϕ(Z). We give an example for nearly-monodisperse chains of poly(n-butyl methacrylate) with a molecular weight of 45,000 tethered to silica spheres with a diameter of 2150 Å. The polymer density profile demonstrates a deep depletion layer next to the surface with a maximum in ϕ(Z) of about 0.7 at about Z = 40 Å. Our experimental ϕ(Z) is compared with various theoretical predictions.     

Recruitment of low threshold motor-units in the trapezius muscle in different static arm positions

A prevailing hypothesis for development of myalgia symptoms in the trapezius muscle is based on observations that in stereotypic activation of muscle the same low-threshold motor-units are the first ones to be recruited, and that these units are active throughout the contraction, until total relaxation. The theory suggests that these units are the first ones in monotonous repetitive work to be subject to degenerative processes, causing pain. The present project was undertaken to evaluate to what extent recruitment of motor-units in the trapezius muscle is position-specific, i.e. if there are motor-units that are recruited over a wide range of arm postures. Fine wire electrode pairs, inserted 2 cm lateral to the midpoint between the acromion and the C7 spinous processus, were used for signal acquisition. Methods for decomposition of the interference patterns were developed, allowing identification of single motor-units in signals registered in different arm positions. Voluntary recruitment of motor-units in the descending portion of the trapezius muscle was studied in 24 different arm positions (0-90 degrees shoulder flexion, 0-45 degrees humeral abduction, and 45-135 degrees elbow flexion) in three subjects. The results showed that the wire electrode technique and the signal processing algorithm employed allowed motor-unit identification in non-isometric conditions. It was found that low threshold motor-units in the trapezius muscle, active over a wide range of arm positions, could be identified in all three subjects. We refer to those as Cinderella, or C, units. These results support the research hypothesis addressed.     

Feasibility of force platform based roadside drowsiness screening – A pilot study

Previous research on driver drowsiness detection has focused on developing in-car systems that continuously monitor the driver while driving and warn him/her when drowsiness compromises safety. In occupational settings a simple test of postural control has showed sensitivity to work shift induced fatigue in drivers. Whether the test is feasible for surveillance purposes in roadside settings is unknown. The present research sought to evaluate the feasibility of using a force platform test of postural control as a breathalyzer-like drowsiness-test at the roadside.     

Synthesis of cobalt nanoparticles to enhance magnetic permeability of metal–polymer composites

Metallic cobalt nanoparticles were synthesized by hydrogen reduction method. Particles were coated in situ with carbon by adding ethene to reaction flow. Particles were characterized by transmission electron microscopy, energy dispersive X-ray emission, X-ray diffraction, X-ray fluorescence and BET method. The observed cobalt particle size distributions in different cobalt batches produced with unvarying reaction parameters was reproducible: The mean diameter of primary cobalt particle varied only 5% from the mean value of 76 nm in different batches. Increased carbon precursor concentration decreased mean diameter of cobalt particles to 17 nm. The produced nanoparticles were used as filler material in 0–3 type metal–polymer composites. Composite samples with varying filler loading were fabricated with mixing extrusion and injection moulding techniques. The magnetic properties of the fabricated composites were measured up to 1 GHz. In order to analyse the particle distribution in composite matrix and its effect on magnetic properties the microstructure was studied.     

Merging ‘reasoning’ and filtering in a bayesian framework—some sensitivity and optimality aspects

An approach is described how to incorporate knowledge of symbolic/logic character into a conventional framework of noisy observations in dynamical systems. The idea is based on approximating the optimal solution that could theoretically be computed if a complete Bayesian framework were known (and infinite computational power were available). The nature of the approximations, the deviations from optimality and the sensitivity to ad hoc parameters are specifically addressed. This merging of logic and numerics is essential in many problems of adaptation in control and signal processing.     

Volume integral equations in non-linear 3-D magnetostatics

In this paper a discussion of volume integral formulations in three-dimensional non-linear magnetostatics is presented. Integral formulations are examined in connection with Whitney's elements in order to find new approaches. A numerical algorithm based on a formulation implying properly the continuity conditions of magnetic field strength H, i.e. an h-type formulation, is introduced. Results of demanding application problems are shown demonstrating the characteristics of this kind of volume integral approach. In addition, a discussion of the parallelized version of the numerical code based on the h-type approach is presented appended with numerical results illustrating the advantages of combining integral formulations with concurrent computing.     

Oligomeric interaction of the PapB transcriptional regulator with the upstream activating region of pili adhesin gene promoters in Escherichia coli

1. Prostanoid receptor-mediated sensitization, or excitation, of sensory nerve fibres contributes to the generation of hyperalgesia. To characterize the prostanoid receptors present on sensory neurones, biochemical assays were performed on primary cultures of adult rat dorsal root ganglia (DRG) and the F-11 (embryonic rat DRG x neuroblastoma hybrid) cell line. 2. In DRG cultures, the IP receptor agonists, cicaprost and carbaprostacyclin (cPGI2) stimulated cyclic AMP accumulation. Prostaglandin E2 (PGE2) also increased cyclic AMP levels, but to a lesser extent, while carbocyclic thromboxane A2 (cTxA2), PGD2 and PGF2alpha had negligible effects. The rank order of agonist potency was cicaprost>PGE2=BMY45778=cPGI2=PGI2. In the F-11 cells, the rank order of agonist potency for the stimulation of cyclic AMP accumulation was: cicaprost>iloprost=cPGI2=PGI2=BMY45778>PGE2=cTXA2++ +. In DRG cultures, cicaprost induced significantly more accumulation of inositol phosphates than PGE2. 3. To examine the effects of prostanoids on C-fibre activity, extracellular recordings of d.c. potentials from the rat isolated vagus nerve were made with the 'grease-gap' technique. PGI2 (0.1 nM-10 microM) produced the largest depolarizations of the nerve. The rank order of agonist potency was: PGI2=cPGI2=PGE1>cTXA2>PGE2=PGD2=TXB2>PGF2alpha. 4. Prior depolarization of nerves with either forskolin (10 microM) or phorbol dibutyrate (1 microM) alone significantly reduced the response to PGI2 (10 microM), while simultaneous application of both forskolin and phorbol dibutyrate attenuated PGI2 responses almost completely. 5. Putative EP1 and/or TP receptor-selective antagonists had no effect on the responses to PGI2, cPGI2 or PGE2 in the three preparations studied. 6. Collectively, these data are consistent with a positive coupling of IP receptors to both adenylyl cyclase and phospholipase C in sensory neurones. These findings suggest that IP receptors play a major role in the sensitization of rat sensory neurones.     

Graphite intercalation chemistry: An interpretive review

It was but five years ago that Forsman, and Ebert and Selig suggested independently that redox chemistry might be intrinsic to the formation of so-called acceptor compounds. Since then, much of the work in chemical aspects of intercalation has been specifically directed at verifying or disproving this hypothesis. The wealth of new data compiled in the process, coupled with a meticulous review of past evidence, confirms the essential role of oxidation in this genre of intercalation reactions.This review addresses two particular issues in the chemistry of acceptor type intercalants. First, how the oxidative or coordinating capability of a chemical species relates to its behavior as an intercalant. There has been considerable emphasis on the broad spectrum of interactions which exist, from weak charge transfer (Br₂ compounds), to oxidative intercalation (e.g., HNO₃), to reactions so vigorous that intercalation is only achieved with accompanying fluorination of the lattice and partial destruction of the sp² character of the carbon network (certain inorganic fluoride systems). Ebert and Selig have pointed out that detrimental oxidations of this sort are always an alternate reaction pathway in oxidative intercalation; the particular intercalant and reaction conditions determine which products will dominate. Secondly, what is the mechanism by which the intercalant interacts with the π-electron system and what are the reactive intermediates? In contrast to the previous topic—which relies on concrete evidence such as final product composition and properties for its resolution—here the approach has been largely hypothetical, relying on analogy to inorganic coordination compounds and organic π-systems which participate in charge transfer reactions. Here also lies, perhaps, the greatest future challenge to the intercalation chemist. For while the devising of possible reaction mechanisms is accomplished easily enough, experimental confirmation is always difficult. However, the past record of cooperation between chemist and physicist, experimenter and theoretician in intercalation science is an impressive one. If this question of mechanism is approached with the same gusto that has characterized past efforts, we should have some answers before long.     

Genetic heterogeneity of autosomal dominant amelogenesis imperfecta demonstrated by its exclusion from the AIH2 region on human chromosome 4Q

Amelogenesis imperfecta (AI) is a group of hereditary enamel defects, characterized by large clinical diversity. On the basis of differences in clinical manifestation and inheritance pattern, 14 different subtypes have been recognized. A locus for autosomal dominant AI (ADAI) of local hypoplastic type was recently mapped to the region between D4S392 and D4S395 on the long arm of chromosome 4. To test whether the chromosome 4 locus is responsible for other forms of AI as well, a linkage study was carried out with 17 families representing at least five clinical forms of ADAI. Admixture tests for heterogeneity performed with the marker D4S2456 gave statistical support for genetic heterogeneity of ADAI with the odds 78:1. Linkage to the ADAI locus on chromosome 4q (AIH2) could only be demonstrated with families expressing the local hypoplastic type, and there was no support for heterogeneity within that group of families. Furthermore, linkage could be excluded for five families with other clinical forms of ADAI. The data therefore demonstrated that ADAI is genetically heterogeneous, and that at least two loci for it exist.