Designing and Rightsizing the Information System Architecture

Information system design and sizing constitute a complex, top-down process that tailors the technology architecture to application requirements. Practitioners usually tackle this top-down process by focusing on individual design aspects, such as data or specific applications, and by relying on their previous experiences to compare alternative architectural solutions. Acquisition costs are usually accounted for, but related operating and maintenance costs are often neglected or underestimated. The complexity of optimizing individual design problems leads researchers to avoid a global optimization perspective and, thus, the IS architecture is usually a result of the juxtaposition of multiple local optima.This paper takes an overall perspective on the cost minimization problem of information system design to achieve a better trade-off between cost and performance over the whole expected life of the technology architecture. A comprehensive design methodology is discussed as an integrating framework that accounts for all categories of costs, including design, implementation, maintenance, and operation, to achieve a globally cost-minimizing solution.     

Selecting CRM packages based on architectural,functional, and cost requirements: Empirical validation of a hierarchical ranking model

This study describes a hierarchical ranking model to help the selection of CRM (customer relationship management) packages based on their functional and technical quality. The model is tested empirically by applying the hierarchical analytical process (AHP) to a sample of 42 CRM packages. Results indicate how functionally similar packages can differ substantially in their technical quality and, thus, in their ability to be integrated within a companys information system. The hierarchical model is verified to be dependable, since the quality-based ranking of packages is found to have a low rank-reversal probability as a consequence of managers uncertainty in weighing the relevance of different quality variables. From a practical standpoint, these results confirm that CRM packages differentiate in measurable quality variables, which can be used by practitioners as a framework to gather and evaluate software-selection information during feasibility analyses.     

Hepatic and Extrahepatic Sources and Manifestations in Endoplasmic Reticulum Storage Diseases

Alpha-1-antitrypsin (AAT) and fibrinogen are secretory acute phase reactant proteins. Circulating AAT and fibrinogen are synthesized exclusively in the liver. Mutations in the encoding genes result in conformational abnormalities of the two molecules that aggregate within the rough endoplasmic reticulum (RER) instead of being regularly exported. That results in AAT-deficiency (AATD) and in hereditary hypofibrinogenemia with hepatic storage (HHHS). The association of plasma deficiency and liver storage identifies a new group of pathologies: endoplasmic reticulum storage disease (ERSD).     

新型PBT纤维的进展

简单阐述了PET、FIT、PBT纤维的发展历程。重点介绍了改性PBT长丝Mirhon WE的特性。     

Effect of Seepage-Induced Nonhydrostatic Pressure Distribution on Bed-Load Transport and Bed Morphodynamics

Bed-load transport is commonly evaluated in the condition of a hydrostatic pressure distribution of the flow field; while this condition is reasonable for quasi-steady, quasi-uniform rectilinear flows, it cannot be satisfied in a large variety of flow conditions, i.e., near an obstacle as in the case of a bridge pier. The dimensionless Shields number, which contains the assumption of a hydrostatic pressure distribution in its denominator, therefore cannot be strictly applied to evaluate bed-load transport in all the configurations where nonhydrostatic pressure distributions are observed. In the present work, a generalization of the Shields number is proposed for the case of nonhydrostatic pressure distribution produced by groundwater flow. Experiments showing the effects of vertical groundwater flow on the bed morphodynamics are presented. The comparison between the experimental observations and numerical results, obtained by means of a morphodynamic model which employs the new formulation of the Shields number, suggests that the proposed generalization of the Shields number is able to account the effect of the nonhydrostatic pressure distribution on the bed-load transport.     

Joint Optimization of Hardware and Network Costs for Distributed Computer Systems

Multiple combinations of hardware and network components can be selected to design an information technology (IT) infrastructure that satisfies requirements. The professional criterion to deal with these degrees of freedom is cost minimization. However, a scientific approach has been rarely applied to cost minimization, particularly for the joint optimization of hardware and network systems. This paper provides an overall methodology for combining hardware and network designs in a single cost minimization problem for multisite computer systems. Costs are minimized by applying a heuristic optimization approach to a sound decomposition of the problem. We consider most of the design alternatives that are enabled by current hardware and network technologies, including server sizing, localization of mutitier applications, and reuse of legacy systems. The methodology is empirically verified with a database of costs that has also been built as part of this paper. Verifications consider several test cases with different computing and communication requirements. Cost reductions are evaluated by comparing the cost of methodological results with those of architectural solutions that are obtained by applying professional design guidelines. The quality of heuristic optimization results is evaluated through comparison with lower bounds.     

An Empirical Study on the Relationship Between Software Design Quality, Development Effort and Governance in Open Source Projects

The relationship among software design quality, development effort, and governance practices is a traditional research problem. However, the extent to which consolidated results on this relationship remain valid for open source (OS) projects is an open research problem. An emerging body of literature contrasts the view of open source as an alternative to proprietary software and explains that there exists a continuum between closed and open source projects. This paper hypothesizes that as projects approach the OS end of the continuum, governance becomes less formal. In turn a less formal governance is hypothesized to require a higher-quality code as a means to facilitate coordination among developers by making the structure of code explicit and facilitate quality by removing the pressure of deadlines from contributors. However, a less formal governance is also hypothesized to increase development effort due to a more cumbersome coordination overhead. The verification of research hypotheses is based on empirical data from a sample of 75 major OS projects. Empirical evidence supports our hypotheses and suggests that software quality, mainly measured as coupling and inheritance, does not increase development effort, but represents an important managerial variable to implement the more open governance approach that characterizes OS projects which, in turn, increases development effort.     

High-performance self-routing algorithm for multiprocessor systems with shuffle interconnections

This paper proposes a routing algorithm for the interconnection of multiple processors based on the shortest-path and deflection-routing principles. The routing algorithm, named SPDRA (Shortest Path and Deflection Routing Algorithm), is applied to multiprocessor systems with a single-stage shuffle physical topology. SPDRA is general-purpose, as opposed to the majority of routing algorithms for multiprocessor systems which are optimized for particular traffic patterns generated by a restricted class of parallel algorithms. The general-purpose nature of SPDRA allows perfomance comparisons with a wide class of routing algorithms for multiprocessor systems that, similar to the single-stage shuffle physical topology, have a fixed node-to-processor ratio. The paper compares SPDRA with hypercube algorithms for bidimensional meshes and torus physical topologies, routing algorithms for hierarchical tridimensional tori, and algorithms for routing permutations in shuffle networks, which constitute the most widely accepted approaches for multiprocessor interconnection. SPDRA exhibits a performance advantage for a broad range of network sizes and, in general, the performance advantage grows as the number of processors increases. However, this paper compares the SPDRA algorithm against a limited set of multiprocessor systems and does not demonstrate a general superiority of SPDRA over all systems with a fixed node-to-processor ratio and, especially, with a growing node-to-processor ratio, such as multistage networks.     

Cost–Performance Optimization of Application- and Context-Aware Distributed Infrastructures

Application- and context-aware infrastructures involve the network in the execution of distributed applications through special devices, namely, the application cards, placed in network nodes. The sharp separation of applications and network is smoothed, and by performing part of the distributed application inside the network, it is possible to reduce costs and improve performance with a better optimization of the whole distributed information and communication technology (ICT) infrastructure. This optimization is allowed by the additional degrees of freedom of placing cards in nodes and of assigning applications to such cards. In this paper, we provide an optimization algorithm that minimizes the total cost of the entire distributed ICT infrastructure, given a target performance objective defined as the end-to-end delay for the completion of the distributed application tasks. We focus on two sample applications that are well suited for application- and context-aware infrastructures: caching and protocol translation. The joint optimization of computing and communication resources is an innovative contribution of this paper, as, in the literature, hardware and network components are typically optimized separately. Results show that the total infrastructural cost savings are in the range of 15%-20%. However, savings can be obtained only if cards satisfy a cost-performance curve that is also analyzed.