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1.
Leonardo Candela Fuat Akal Henri Avancini Donatella Castelli Luigi Fusco Veronica Guidetti Christoph Langguth Andrea Manzi Pasquale Pagano Heiko Schuldt Manuele Simi Michael Springmann Laura Voicu 《International Journal on Digital Libraries》2007,7(1-2):59-80
This paper introduces DILIGENT, a digital library infrastructure built by integrating digital library and Grid technologies and resources. This infrastructure
allows different communities to dynamically build specialised digital libraries capable to support the entire e-Science knowledge
production and consumption life-cycle by using shared computing, storage, content, and application resources. The paper presents
some of the main software services that implement the DILIGENT system. Moreover, it exemplifies the provided features by presenting how the DILIGENT infrastructure is being exploited in supporting the activity of user communities working in the Earth Science Environmental
sector.
This work is partially funded by the European Commission in the context of the DILIGENT project, under the 2nd call of FP6 IST priority. 相似文献
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ABSTRACT The mixture of citrus fruits (orange, grapefruit, mandarin, and lemon) wastes was utilized to obtain high surface area activated carbon (AC) by H3PO4 activation. The production conditions were optimized and the optimum conditions were determined. The optimal-activated carbon (CFWAC) was characterized by various physicochemical techniques. CFWAC was also used as a sorbent for Pb (II) ions from water. Batch experiments were performed to explore the adsorption capacity and mechanism. The Langmuir isotherm and pseudo-second-order kinetic model showed good fitness to the experimental data. The maximum Pb (II) adsorption capacity of CFWAC was found to be 163.93 mg/g. 相似文献
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Alev Taskin Gumus Ali Fuat Guneri Selcan Keles 《Expert systems with applications》2009,36(10):12570-12577
In this study, an integrated supply chain (SC) design model is developed and a SC network design case is examined for a reputable multinational company in alcohol free beverage sector. Here, a three echelon SC network is considered under demand uncertainty and the proposed integrated neuro-fuzzy and mixed integer linear programming (MILP) approach is applied to this network to realize the design effectively. Matlab 7.0 is used for neuro-fuzzy demand forecasting and, the MILP model is solved using Lingo 10.0. Then Matlab 7.0 is used for artificial neural network (ANN) simulation to supply a comparative study and to show the applicability and efficiency of ANN simulation for this type of problem. By evaluating the output data, the SC network for this case is designed, and the optimal product flow between the factories, warehouses and distributors are calculated. Also it is proved that the ANN simulation can be used instead of analytical computations because of ensuring a simplified representation for this method and time saving. 相似文献
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The wound is induced by several mechanical and metabolic factors. In the etiology of the wound recovery,
excessive oxidative stress, calcium ion (Ca2+) influx, and apoptosis have important roles. Ca2+-permeable TRPM2 channel is activated by oxidative stress. Protective roles of Hypericum perforatum extract (HP) on the mechanical nerve injury-induced apoptosis and oxidative toxicity through regulation of TRPM2 in the experimental animals were
recently reported. The potential protective roles in HP treatment were evaluated on the TRPM2-mediated cellular
oxidative toxicity in the renal epithelium (MPK) cells. The cells were divided into three groups as control, wound,
and wound + HP treatment (75 µM for 72 h). Wound diameters were more importantly decreased in the wound+HP
group than in the wound group. In addition, the results of laser confocal microscopy analyses indicated protective
roles of HP and TRPM2 antagonists (N-(p-Amylcinnamoyl) anthranilic acid and 2-aminoethyl diphenylborinate)
against the wound-induced increase of Ca2+ influx and mitochondrial ROS production. The wound-induced increase
of early (annexin V-FITC) apoptosis and late (propidium iodide) apoptosis were also decreased in the cells by the HP
treatment. In conclusion, HP treatment acted protective effects against wound-mediated oxidative cell toxicity and
apoptosis through TRPM2 inhibition. These effects may be attributed to their potent antioxidant effect. 相似文献
6.
Ibrahim Gunes Adem Cicek Kubilay Aslantas Fuat Kara 《Transactions of the Indian Institute of Metals》2014,67(6):909-917
In this study, the effects of deep cryogenic treatment (DCT) on the wear resistance of AISI 52100 bearing steel were investigated. For this purpose, a number of bearing steel samples were held for different times (12, 24, 36, 48, 60 h) at deep cryogenic temperatures (?145 °C). The wear experiments were carried out in a ball–disk arrangement, by applying loads of 10 and 20 N and a sliding velocity of 0.15 m/s. After conducting the experimental studies, 36 h was found to be the optimal holding time. At this holding time, the wear rate and friction coefficient were decreased, while the hardness reached to maximum values. It was observed that DCT led to significant microstructural changes, which resulted in improved tribological properties. 相似文献
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Balci Fuat; Day Mark; Rooney Aislinn; Brunner Dani 《Canadian Metallurgical Quarterly》2009,123(6):1353
Huntington’s disease is characterized by corticostriatal dysfunction and degeneration of the striatum with progressive loss of the medium spiny neurons. These circuits are important for instrumental responding, interval timing, and temporal control over motor output. We investigated the acquisition of timed operant responding in two R6/2 Huntington’s Disease models, differing in CAG repeat length and genetic background (115 and 250 CAG repeats, and a mixed CBAxC57 or pure C57 background) and their corresponding wild type controls using the peak procedure. Both mouse lines exhibited similar response control deficits. In unreinforced peak trials, mice either did not learn to terminate an ongoing response past reinforcement time or required more trials to acquisition compared to the wild type mice. While transgenic and wild type mice did not exhibit differences in temporal accuracy, response curves were flatter in transgenic mice, suggesting decreased temporal control over operant responding. The results are discussed in terms of the neurobiology of interval timing, instrumental responding, and the neuropathology of HD and R6/2 mice. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Steel ratios for cost optimum reinforced concrete beams 总被引:1,自引:0,他引:1
The amount of main-reinforcement steel in reinforced concrete beams is limited by maximum and minimum steel ratios. No guidance is given by design codes as how to choose the ratios within the permissible range. Using systematic direct search, the influence of various factors on the optimal steel ratio for single-reinforced concrete beams is studied. Using the design code of the American Concrete Institute, it is found that the most influential factors in selection of steel ratios are support conditions and material costs. Applied loads and yield strength of steel are shown to have some influence. 相似文献