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1.
Giorgio Guglieri Valeria Mariano Fulvia Quagliotti Alessandro Scola 《Journal of Intelligent and Robotic Systems》2011,61(1-4):399-421
The Italian SMAT project is a civilian program supported by Piemonte Region developed for the territorial monitoring and surveillance and for the prevention of natural hazards. In a different way from the previous surveillance programs, the SMAT project is based on the use of several unmanned platforms that are able to cooperate through ground coordination and control station. The flight in non-segregated airspace, needed in order to accomplish the territorial monitoring mission, is a main issue to be investigated and defined, because of the current lack of a common consensus and agreement on the regulations of UAS. The present work outlines the international initiatives that deal with the development of the regulatory framework on airworthiness and certification of UAS and their potential impact on the SMAT project. 相似文献
2.
The multimod application framework: a rapid application development tool for computer aided medicine 总被引:1,自引:0,他引:1
Viceconti M Zannoni C Testi D Petrone M Perticoni S Quadrani P Taddei F Imboden S Clapworthy G 《Computer methods and programs in biomedicine》2007,85(2):138-151
This paper describes a new application framework (OpenMAF) for rapid development of multimodal applications in computer-aided medicine. MAF applications are multimodal in data, in representation, and in interaction. The framework supports almost any type of biomedical data, including DICOM datasets, motion-capture recordings, or data from computer simulations (e.g. finite element modeling). The interactive visualization approach (multimodal display) helps the user interpret complex datasets, providing multiple representations of the same data. In addition, the framework allows multimodal interaction by supporting the simultaneous use of different input-output devices like 3D trackers, stereoscopic displays, haptics hardware and speech recognition/synthesis systems. The Framework has been designed to run smoothly even on limited power computers, but it can take advantage of all hardware capabilities. The Framework is based on a collection of portable libraries and it can be compiled on any platform that supports OpenGL, including Windows, MacOS X and any flavor of Unix/linux. 相似文献
3.
Luca Damilano Giorgio Guglieri Fulvia Quagliotti Ilaria Sale 《Journal of Intelligent and Robotic Systems》2012,65(1-4):27-42
To integrate UASs in the NAS, an improvement in navigation, planning, communication and 4D trajectory control capabilities is mandatory. A way to obtain this enhance is to adopt a Flight Management System. A FMS for an UAS has some differences with respect to one for a manned aircraft, in terms of architecture and performed functions. In particular, from HMI point of view, the specific UAS human factor issues shall be added to the current manned FMS interface lacks. Starting from these considerations, a new FMS HMI for the Alenia Aeronautica TCS has been developed, using as data entry devices two touch screens. 相似文献
4.
Sousa F Mandal S Garrovo C Astolfo A Bonifacio A Latawiec D Menk RH Arfelli F Huewel S Legname G Galla HJ Krol S 《Nanoscale》2010,2(12):2826-2834
In the present study, the in vivo distribution of polyelectrolyte multilayer coated gold nanoparticles is shown, starting from the living animal down to cellular level. The coating was designed with functional moieties to serve as a potential nano drug for prion disease. With near infrared time-domain imaging we followed the biodistribution in mice up to 7 days after intravenous injection of the nanoparticles. The peak concentration in the head of mice was detected between 19 and 24 h. The precise particle distribution in the brain was studied ex vivo by X-ray microtomography, confocal laser and fluorescence microscopy. We found that the particles mainly accumulate in the hippocampus, thalamus, hypothalamus, and the cerebral cortex. 相似文献
5.
Zicarelli F Calabrò S Cutrignelli MI Infascelli F Tudisco R Bovera F Piccolo V 《Journal of the science of food and agriculture》2011,91(7):1213-1221
BACKGROUND: The aim of this trial was to evaluate the replacement of rumen fluid with faeces as inoculum in studying the in vitro fermentation characteristics of diets for ruminants using the in vitro gas production technique. Six iso‐protein diets with different forage/concentrate ratios were incubated with rumen fluid (RI) or faeces (FI) collected from sheep. RESULTS: Most of the fermentation parameters were influenced by diet and inoculum (P < 0.01). With both inocula, organic matter degradability (dOM), cumulative gas production (OMCV) and maximum fermentation rate (Rmax) increased as the amount of concentrate in the diet increased. Rmax was lower with FI vs RI (P < 0.01); dOM was higher with FI vs RI and the diet × inoculum interaction was significant. As expected, with both inocula, Rmax increased as the neutral detergent fibre content of the diet decreased. Significant correlations were obtained using both inocula between OMCV/dOM and gas/volatile fatty acid (VFA), while the correlation VFA/dOM was significant only with FI. The microbial biomass yield calculated by stoichiometric analysis for all diets was higher with FI vs RI. With FI the organic matter used for microbial growth showed an overall decreasing trend as the amount of concentrate in the diet increased. CONCLUSION: The results indicate that both faeces and rumen fluid from sheep have the potential to be used as inoculum for the in vitro gas production technique. Copyright © 2011 Society of Chemical Industry 相似文献
6.
Taddei F Martelli S Reggiani B Cristofolini L Viceconti M 《IEEE transactions on bio-medical engineering》2006,53(11):2194-2200
The aim of this paper is to analyze how the uncertainties in modelling the geometry and the material properties of a human bone affect the predictions of a finite-element model derived from computed tomography (CT) data. A sensitivity analysis, based on a Monte Carlo method, was performed using three femur models generated from in vivo CT datasets, each subjected to two different loading conditions. The geometry, the density and the mechanical properties of the bone tissue were considered as random input variables. Finite-element results typically used in biomechanics research were considered as statistical output variables, and their sensitivity to the inputs variability assessed. The results showed that it is not possible to define a priori the influence of the errors related to the geometry definition process and to the material assignment process on the finite-element analysis results. The errors in the geometric representation of the bone are always the dominant variables for the stresses, as was expected. However, for all the variables, the results seemed to be dependent on the loading condition and to vary from subject to subject. The most interesting result is, however, that using the proposed method to build a finite-element model of a femur from a CT dataset of the quality typically achievable in the clinical practice, the coefficients of variation of the output variables never exceed the 9%. The presented method is hence robust enough to be used for investigating the mechanical behavior of bones with subject-specific finite-element models derived from CT data taken in vivo. 相似文献
7.
Alessandra Gentili Valeria De Pratti Fulvia Caretti Virginia Pérez-Fernández Pierpaolo Tomai Roberta Curini 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2016,33(12):1793-1802
This paper describes a rapid method for confirming residues of thyreostats in meat-based baby foods by using liquid chromatography – dual polarity electrospray – tandem mass spectrometry (LC-ES(±)-MS/MS). Six thioureylenes, belonging to the group of thiouracil and imidazole, were selected for this work: thiouracil (TU), methylthiouracil (MTU), propylthiouracil (PTU), phenylthiouracil (PhTU), mercaptobenzimidazole (MBI) and tapazole (TAP).The amphoteric nature of these compounds allows their electrospray detection in both positive and negative ionisation. Nevertheless, MS detection is not favoured by their low molecular weights, while their chromatographic retention is also thwarted by their high polarity. A pentafluorophenyl (PFP) core-shell phase column was selected to avoid peak asymmetry or peak splitting, and a dual-polarity ionisation method was optimised to obtain a sensitivity as high as possible. The method was validated according to the Commission Decision 657/2002/EC. A simple and fast procedure based on matrix solid phase dispersion (MSPD) was optimised to extract analytes from baby foods with recoveries exceeding 82%. Limit of decision (CCα) and detection capability (CCβ) were lower than the permissible maximum concentration (10 ng g?1). The validated method was then applied to assess the potential occurrence of the six selected thyreostats in nine commercial products. All the samples were found free of contamination. 相似文献
8.
Quadri G Chen X Jawitz JW Tambone F Genevini P Faoro F Adani F 《Environmental science & technology》2008,42(7):2618-2623
In this work, four surfactant-like humic acids (HAs) obtained from garden lignocellulose wastes and kitchen food wastes mixed with garden-lignocellulose wastes, both before and after composting, were tested for surfactant properties and the ability to solubilize tetrachloroethene (PCE). The waste-derived HAs showed good surfactant properties, lowering the water surface tension from 74 mN m(-1) to 45.4 +/- 4.4 mN m(-1), with a critical micelle concentration (CMC) of 1.54 +/- 1.68 g L(-1), which is lower than many synthetic ionic surfactants. CMC was affected by both waste origin and composting processes. The addition of food waste and composting reduced CMC by adding alkyl-C (measured by CP MAS 13C NMR) and N- and S-HA contents (amide molecules), so that a multistep regression was found [CMC = 24.6 - 0.189 alkyl C - 2.64 (N + S); R2 = 0.77, P < 0.10, n = 6]. The four HAs solubilized PCE at the rate of 0.18-0.47 g PCE/g aqueous biosurfactant. These results were much higher than those reported in the literature for a commercial HA (0.026 g/g), but they were in line with those measured in this work for nonionic surfactants such as Tween-80 (0.69 g/g) and Triton X-100 (1.08 g/g). 相似文献
9.
Valente G Martelli S Taddei F Farinella G Viceconti M 《Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine》2012,226(2):161-169
Modelling the mechanical effect of muscles is important in several research and clinical contexts. However, few studies have investigated the effect of different muscle discretizations from a mechanical standpoint. The present study evaluated the errors of a reduced discretization of the lower-limb muscles in reproducing the muscle loading transferred to bones. Skeletal geometries and a muscle data collection were derived from clinical images and dissection studies of two cadaver specimens. The guidelines of a general method previously proposed for a different anatomical district were followed. The data collection was used to calculate the mechanical effect of muscles, i.e. the generalized force vectors, and the errors between a large and a reduced discretization, in a reference skeletal pose and in the extreme poses of the range of motion of joints. The results showed that the errors committed using a reduced representation of muscles could be significant and higher than those reported for a different anatomical region. In particular, the calculated errors were found to be dependent on the individual anatomy and on the skeletal pose. Since different biomechanical applications may require different discretization levels, care is suggested in identifying the number of muscle lines of action to be used in musculoskeletal models. 相似文献
10.
Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2‐Amino‐7‐[4‐fluoro‐2‐(3‐pyridyl)phenyl]‐4‐methyl‐7,8‐dihydro‐6H‐quinazolin‐5‐one Oxime 下载免费PDF全文
Dr. Raffaella Amici Dr. Chiara Bigogno Dr. Roberto Boggio Dr. Andrea Colombo Dr. Stephen M. Courtney Dr. Roberto Dal Zuffo Dr. Giulio Dondio Dr. Fulvia Fusar Dr. Stefania Gagliardi Prof. Dr. Saverio Minucci Dr. Marco Molteni Dr. Christian A. G. N. Montalbetti Dr. Annalisa Mortoni Dr. Mario Varasi Dr. Stefania Vultaggio Dr. Ciro Mercurio 《ChemMedChem》2014,9(7):1574-1585
Heat‐shock protein 90 (Hsp90) is a molecular chaperone involved in the stabilization of key oncogenic signaling proteins, and therefore, inhibition of Hsp90 represents a new strategy in cancer therapy. 2‐Amino‐7‐[4‐fluoro‐2‐(3‐pyridyl)phenyl]‐4‐methyl‐7,8‐dihydro‐6H‐quinazolin‐5‐one oxime is a racemic Hsp90 inhibitor that targets the N‐terminal adenosine triphosphatase site. We developed a method to resolve the enantiomers and evaluated their inhibitory activity on Hsp90 and the consequent antitumor effects. The (S) stereoisomer emerged as a potent Hsp90 inhibitor in biochemical and cellular assays. In addition, this enantiomer exhibited high oral bioavailability in mice and excellent antitumor activity in two different human cancer xenograft models. 相似文献