Precise Extraction of Charge Carrier Mobility for Organic Transistors

Unreliable mobility values, and particularly greatly overestimated values and severely distorted temperature dependences, have recently hampered the development of the organic transistor field. Given that organic field‐effect transistors (OFETs) have been routinely used to evaluate mobility, precise parameter extraction using the electrical properties of OFETs is thus of primary importance. This review examines the origins of the various mobilities that must be determined for OFET applications, the relevant extraction methods, and the data selection limitations, which help in avoiding conceptual errors during mobility extraction. For increased precision, the review also discusses device fabrication considerations, calibration of both the specific gate‐dielectric capacitance and the threshold voltage, the contact effects, and the bias and temperature dependences, which must actually be handled with great care but have mostly been overlooked to date. This review serves as a systematic overview of the OFET mobility extraction process to ensure high precision and will also aid in improving future research.     

Effect of the cultivation mode on red pigments production from Monascus ruber

In submerged cultures performed in chemically defined fermentation medium containing glucose and glutamate, the growth and production of water‐soluble red pigments and citrinin by the filamentous fungus Monascus ruber were studied under various carbon/nitrogen (C/N) ratios. The specific production of the red pigments was optimal at a glucose/glutamate ratio of about 10 and then steadily decreased at higher C/N ratio. In contrast, the production of the mycotoxin increased with increased C/N with an optimum in the range of 30–45. In a fed‐batch mode, it was also found that the production of pigments was not favoured in fed‐batch mode by feeding the medium with glucose while keeping the C/N ratio lower than 10. This low production likely resulted from concurrent high accumulation of L‐malic acid that was reported to inhibit this production. In contrast, this mode of cultivation was rather favourable for the production of the mycotoxin.     

Physical Stability of Octenyl Succinate–Modified Polysaccharides and Whey Proteins for Potential Use as Bioactive Carriers in Food Systems

The high cost and potential toxicity of biodegradable polymers like poly(lactic‐co‐glycolic)acid (PLGA) has increased the interest in natural and modified biopolymers as bioactive carriers. This study characterized the physical stability (water sorption and state transition behavior) of selected starch and proteins: octenyl succinate–modified depolymerized waxy corn starch (DWxCn), waxy rice starch (DWxRc), phytoglycogen, whey protein concentrate (80%, WPC), whey protein isolate (WPI), and α‐lactalbumin (α‐L) to determine their potential as carriers of bioactive compounds under different environmental conditions. After enzyme modification and particle size characterization, glass transition temperature and moisture isotherms were used to characterize the systems. DWxCn and DWxRc had increased water sorption compared to native starch. The level of octenyl succinate anhydrate (OSA) modification (3% and 7%) did not reduce the water sorption of the DWxCn and phytoglycogen samples. The Guggenheim–Andersen–de Boer model indicated that native waxy corn had significantly (P < 0.05) higher water monolayer capacity followed by 3%‐OSA‐modified DWxCn, WPI, 3%‐OSA‐modified DWxRc, α‐L, and native phytoglycogen. WPC had significantly lower water monolayer capacity. All Tg values matched with the solid‐like appearance of the biopolymers. Native polysaccharides and whey proteins had higher glass transition temperature (Tg) values. On the other hand, depolymerized waxy starches at 7%‐OSA modification had a “melted” appearance when exposed to environments with high relative humidity (above 70%) after 10 days at 23 °C. The use of depolymerized and OSA‐modified polysaccharides blended with proteins created more stable blends of biopolymers. Hence, this biopolymer would be suitable for materials exposed to high humidity environments in food applications.     

Computation of Running Averages

This brief presents and compares several recursive and nonrecursive techniques for the efficient computation of the running average of discrete signals. First of all, the standard recursive algorithm is considered and its long-term accuracy is assessed when the floating-point arithmetic is employed. A cheap refreshing strategy is proposed as a means of keeping the computed value close enough to the exact one. Then, two alternative nonrecursive algorithms, requiring only log₂N additions, are developed, which are as reliable and accurate as the direct implementation     

Retrospective mapping of burnt areas in Central Siberia using a modification of the normalised difference water index

The boreal forest contains almost half the total carbon pool of world forest ecosystems, and so has a very significant role in global biogeochemical cycles. The flux of greenhouse gases in and out of these forests is influenced strongly by disturbances such as diseases, logging and predominantly fire. It is important to quantify these disturbances to enable the modelling of major greenhouse gases. However, because of the remoteness and vastness of the boreal forest, little data is available on the type, extent, frequency and severity of these disturbances in Siberia. For burnt areas, two of the more responsive wavelengths are the short wave infra-red (SWIR) and the near infra-red (NIR). These produce a vegetation index, the normalised difference SWIR (NDSWIR) capable of detecting retrospective disturbances. Here we combine the NDSWIR from MODIS imagery acquired in the summer of 2003 with thermal anomaly data from 1992 to 2003 to detect and date areas which burnt at some point between 1992 and 2003. The semi-automated method is called SWIR and Thermal ANomalies for Detecting Disturbances (STANDD) and is complemented by an Normalised Difference Vegetation Index (NDVI) differencing method using MODIS 2002 and 2003 imagery to ensure reliable detection of area burnt in the year of image acquisition (i.e. 2003). The area of this study covers approximately 3 million km² stretching from Lake Baikal in the south to the Laptev Sea in the north, above the Arctic Circle. Landsat ETM+ images were used to validate the shape and areal extent of the burnt areas resulting in an 81% overall accuracy with a kappa coefficient of agreement of 0.63.     

Direct synthesis of copper faujasite

Copper containing faujasite has been successfully prepared for the first time using a direct synthesis method. Faujasite type zeolite can be prepared in the presence of copper species by tuning the synthesis conditions. Ammonium hydroxide was used to form a copper complex that was later mixed with the reacting gel. Sodium is required to obtain copper faujasite. The complete elimination of sodium ions from the starting gel produces amorphous material. Crystallization took place at 358 K for 11 days. Crystallization temperature of 373 K produces ANA type zeolite as an impurity. Increasing by two times the amount of copper complex added to the reacting gel increases the crystallization time of Cu-FAU from 11 to 20 days (the crystallization rate decreases). The copper containing faujasite obtained was characterized by XRD, FESEM, EDX, EPR, FT-IR, TPR, and BET. According to the XRD pattern only FAU type zeolite was obtained. According to TPR experiments, the reduction temperature for Cu²⁺ ions present in Cu-FAU prepared by direct synthesis was 70 K more than for Cu-FAU prepared by ion-exchange. This difference can be due to the different location of the copper ions in the supercages or in the sodalite cages of the faujasite.     

Creating and Justifying Research and Development Value: Scope,Scale, Skill and Social Networking of R&D

In this paper we describe a framework for analysing the creation and justification of Research & Development. The 4S framework is developed for analysing the scope, scale, skills and social network aspects of Research & Development value. The framework is based on social system theory, a process contingency model, and recent Research & Development metrics. We present a first empirical assessment based on a workshop using the 4S framework for leveraging Research & Development. Results that assist in the assessment of value creation utilising R & D within networks are very relevant in high tech industries. The multi–dimensional process approach of this framework seems promising for understanding and managing R&D value creation, but needs further operationalisation. Case studies are described and a Dutch network on leveraging R&D has been initiated.     

Desensitization of mutant acetylcholine receptors in transgenic mice reduces the amplitude of neuromuscular synaptic currents

While the slow onset of desensitization of nicotinic acetylcholine receptors (AChRs), relative to the rate of acetylcholine removal, excludes this kinetic state from shaping synaptic responses in normal neuromuscular transmission, its role in neuromuscular disorders has not been examined. The slow-channel congenital myasthenic syndrome (SCCMS) is a disorder caused by point mutations in the AChR subunit-encoding genes leading to kinetically abnormal (slow) channels, reduced miniature endplate current amplitudes (MEPCs), and degeneration of the postsynaptic membrane. Because of this complicated picture of kinetic and structural change in the neuromuscular junction, it is difficult to assess the importance of the multiple factors that may be responsible for the reduced endplate current amplitudes, and ultimately the clinical syndrome. In order to address this we have used a transgenic mouse model for the SCCMS that has slow AChR ion channels and reduced endplate responsiveness in the absence of any of the degenerative changes. We found that the reduction in MEPC amplitudes in these mice could not be explained by either reduced AChR number or by reduced AChR channel conductance. Rather, we found that the mutant AChRs in situ manifested an activity-dependent reduction in sensitivity that caused diminished MEPC and endplate current amplitude with nerve stimulation. This observation demonstrates that the basis for the reduction in MEPC amplitudes in the SCCMS may be multifactorial. Moreover, these findings demonstrate that, under conditions that alter their rate of desensitization, the kinetic properties of nicotinic AChRs can control the strength of synaptic responses.