全文获取类型
收费全文 | 85514篇 |
免费 | 1114篇 |
国内免费 | 406篇 |
专业分类
电工技术 | 805篇 |
综合类 | 2316篇 |
化学工业 | 11889篇 |
金属工艺 | 4802篇 |
机械仪表 | 3066篇 |
建筑科学 | 2217篇 |
矿业工程 | 563篇 |
能源动力 | 1154篇 |
轻工业 | 3777篇 |
水利工程 | 1272篇 |
石油天然气 | 349篇 |
武器工业 | 1篇 |
无线电 | 9367篇 |
一般工业技术 | 16564篇 |
冶金工业 | 2968篇 |
原子能技术 | 266篇 |
自动化技术 | 25658篇 |
出版年
2022年 | 72篇 |
2021年 | 97篇 |
2020年 | 59篇 |
2019年 | 48篇 |
2018年 | 14497篇 |
2017年 | 13415篇 |
2016年 | 10008篇 |
2015年 | 656篇 |
2014年 | 274篇 |
2013年 | 296篇 |
2012年 | 3221篇 |
2011年 | 9516篇 |
2010年 | 8346篇 |
2009年 | 5626篇 |
2008年 | 6852篇 |
2007年 | 7833篇 |
2006年 | 182篇 |
2005年 | 1267篇 |
2004年 | 1171篇 |
2003年 | 1228篇 |
2002年 | 592篇 |
2001年 | 136篇 |
2000年 | 199篇 |
1999年 | 91篇 |
1998年 | 163篇 |
1997年 | 95篇 |
1996年 | 93篇 |
1995年 | 49篇 |
1994年 | 44篇 |
1993年 | 40篇 |
1992年 | 28篇 |
1991年 | 29篇 |
1988年 | 20篇 |
1983年 | 15篇 |
1981年 | 16篇 |
1969年 | 25篇 |
1968年 | 43篇 |
1967年 | 34篇 |
1966年 | 43篇 |
1965年 | 44篇 |
1963年 | 28篇 |
1962年 | 22篇 |
1961年 | 18篇 |
1960年 | 30篇 |
1959年 | 35篇 |
1958年 | 37篇 |
1957年 | 37篇 |
1956年 | 34篇 |
1955年 | 63篇 |
1954年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 546 毫秒
1.
Giorgio Valabrega Giulia Scotto Valentina Tuninetti Arianna Pani Francesco Scaglione 《International journal of molecular sciences》2021,22(8)
Poly(ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for PARP cofactor (NAD+) and trapping PARP on the DNA. In this way, they inhibit single-strand DNA damage repair. These drugs have been approved in recent years for the treatment of ovarian cancer. Although they share some similarities, from the point of view of the chemical structure and pharmacodynamic, pharmacokinetic properties, these drugs also have some substantial differences. These differences may underlie the different safety profiles and activity of PARPi. 相似文献
2.
Guglielmina Chimienti Anna Picca Flavio Fracasso Francesco Russo Antonella Orlando Giuseppe Riezzo Christiaan Leeuwenburgh Vito Pesce Angela Maria Serena Lezza 《International journal of molecular sciences》2021,22(4)
Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related boundaries of CR efficacy are not fully elucidated. We used liver samples from ad libitum-fed (AL) rats divided in: 18-month-old (AL-18), 28-month-old (AL-28), and 32-month-old (AL-32) groups, and from CR-treated (CR) 28-month-old (CR-28) and 32-month-old (CR-32) counterparts to assay the effect of CR on several mitochondrial markers. The age-related decreases in citrate synthase activity, in TFAM, MFN2, and DRP1 protein amounts and in the mtDNA content in the AL-28 group were prevented in CR-28 counterparts. Accordingly, CR reduced oxidative mtDNA damage assessed through the incidence of oxidized purines at specific mtDNA regions in CR-28 animals. These findings support the anti-aging effect of CR up to 28 months. Conversely, the protein amounts of LonP1, Cyt c, OGG1, and APE1 and the 4.8 Kb mtDNA deletion content were not affected in CR-28 rats. The absence of significant differences between the AL-32 values and the CR-32 counterparts suggests an age-related boundary of CR efficacy at this age. However, this only partially curtails the CR benefits in counteracting the generalized aging decline and the related mitochondrial involvement. 相似文献
3.
Giorgio Benedek Joseph R. Manson Salvador Miret-Artés 《Advanced materials (Deerfield Beach, Fla.)》2020,32(25):2002072
Atom scattering is becoming recognized as a sensitive probe of the electron–phonon interaction parameter λ at metal and metal-overlayer surfaces. Here, the theory is developed, linking λ to the thermal attenuation of atom scattering spectra (in particular, the Debye–Waller factor), to conducting materials of different dimensions, from quasi-1D systems such as W(110):H(1 × 1) and Bi(114), to quasi-2D layered chalcogenides, and high-dimensional surfaces such as quasicrystalline 2ML-Ba(0001)/Cu(001) and d-AlNiCo(00001). Values of λ obtained using He atoms compare favorably with known values for the bulk materials. The corresponding analysis indicates in addition, the number of layers contributing to the electron–phonon interaction, which is measured in an atom surface collision. 相似文献
4.
Mobile software applications have to cope with a particular environment that involves small size, limited resources, high autonomy requirements, competitive business models and many other challenges. To provide development guidelines that respond to these needs, several practices have been introduced; however, it is not clear how these guidelines may contribute to solve the issues present in the mobile domain. Furthermore, the rapid evolution of the mobile ecosystem challenges many of the premises upon which the proposed practices were designed. In this paper, we present a survey of the literature on software assurance practices for mobile applications, with the objective of describing them and assessing their contribution and success. We identified, organized and reviewed a body of research that spans in three levels: software development processes, software product assurance practices, and software implementation practices. By carrying out this literature survey, we reviewed the different approaches that researchers on Software Engineering have provided to address the needs that raise in the mobile software development arena. Moreover, we review the evolution of these practices, identifying how the constant changes and modernization of the mobile execution environment has impacted the methods proposed in the literature. Finally, we introduced discussion on the application of these practices in a real productive setting, opening an area for further research that may determine if practitioners have followed the proposed assurance paradigms. 相似文献
5.
This paper presents an integrated passive damping approach in hybrid metal-CFRP parts for structural applications. In this concept a viscoelastic material is embedded in the joint zone of the hybrid component. To examine the connection strength single-lap-joint specimens were produced and tested and the influence of the used material combinations, different surface structures, and different process parameters i.e. the moment of cross-linking were evaluated. Afterwards, the metal-CFRP hybrids were tested in quasi-static tests to assess their connection strength and failure behaviour. Dynamic cyclic tensile tests with step-wise increased loading conditions were performed to determine the specimens damping behaviour and to estimate their fatigue performance. Finally, these results are compared to a state of the art metal-CFRP hybrid with rivets connecting both materials. 相似文献
6.
In this paper, we consider the classical finite mixture model, which is an effective tool for modeling lifetime distributions for random samples from heterogeneous populations. We discuss new results on stochastic comparison for two finite mixtures when each of them is drawn from one of the following semiparametric families, i.e., proportional hazards, accelerated lifetime and proportional reversed hazards. 相似文献
7.
8.
9.
Variations of Incomplete Open Cubes is the major project by the twentieth-century conceptual artist Sol LeWitt. In this paper we interpret the enumerative component of the project as embeddings of graphs. This formulation permits use of an algorithm to check the completeness of the list of the structures produced by the artist. Our conclusion is that the artist found the correct number of structures (that is, 122), but that his list contains a mistake in the presentation of a pair of incomplete cubes, a discovery that appears not to have been noted before. 相似文献
10.