Effects of a multidisciplinary rehabilitation programme on health-related quality of life in patients with prolonged musculoskeletal disorders: a 6-month follow-up of a prospective controlled study

PURPOSE: The aim of this prospective, controlled, follow-up study (6 months) was to examine the effects of a multidisciplinary rehabilitation programme on perceived health-related quality of life (HRQL) in patients with prolonged musculoskeletal disorders (PMSD). The programme focused on body awareness therapy and cognitive and relaxation treatment. METHOD: The rehabilitation group comprised 122 patients, and there were 114 patients in the matched control group (CG). Both groups of patients had access to primary health care. Baseline data were compared with 6-month follow-up data within and between the groups. The following measurements were employed: HRQL (Nottingham Health Profile), body awareness, postural control, pain (VAS), pain-related medicine consumption, isometric arm muscle endurance, aerobic capacity, psychosomatic symptoms, physical and psychosocial working environment and sick leave. RESULTS: Variables that improved significantly as compared with the CG were: HRQL, anxiety, pain related to movements, psychosomatic symptoms and need for pain-related medicines. CONCLUSIONS: The multidisciplinary rehabilitation programme used here improved HRQL in patients with PMSD to a greater extent than the standard treatment provided within primary heath care (p = 0.01) at least in the short term.     

Eliminating the effect of freezing frames on user perceptive by using a time interleaving technique

Streaming video over a wireless network faces several challenges such as high packet error rates, bandwidth variations, and delays, which could have negative effects on the video streaming and the viewer will perceive a frozen picture for certain durations due to loss of frames. In this study, we propose a Time Interleaving Robust Streaming (TIRS) technique to significantly reduce the frozen video problem and provide a satisfactory quality for the mobile viewer. This is done by reordering the streaming video frames as groups of even and odd frames. The objective of streaming the video in this way is to avoid the losses of a sequence of neighbouring frames in case of a long sequence interruption. We evaluate our approach by using a user panel and mean opinion score (MOS) measurements; where the users observe three levels of frame losses. The results show that our technique significantly improves the smoothness of the video on the mobile device in the presence of frame losses, while the transmitted data are only increased by almost 9% (due to reduced time locality).     

Efficient document image binarization using heterogeneous computing and parameter tuning

In the context of historical document analysis, image binarization is a first important step, which separates foreground from background, despite common image degradations, such as faded ink, stains, or bleed-through. Fast binarization has great significance when analyzing vast archives of document images, since even small inefficiencies can quickly accumulate to years of wasted execution time. Therefore, efficient binarization is especially relevant to companies and government institutions, who want to analyze their large collections of document images. The main challenge with this is to speed up the execution performance without affecting the binarization performance. We modify a state-of-the-art binarization algorithm and achieve on average a 3.5 times faster execution performance by correctly mapping this algorithm to a heterogeneous platform, consisting of a CPU and a GPU. Our proposed parameter tuning algorithm additionally improves the execution time for parameter tuning by a factor of 1.7, compared to previous parameter tuning algorithms. We see that for the chosen algorithm, machine learning-based parameter tuning improves the execution performance more than heterogeneous computing, when comparing absolute execution times.

     

A Comparison of Leisure Time Spent in a Garden with Leisure Time Spent Indoors: On Measures of Restoration in Residents in Geriatric Care

During the past 20 years, findings have indicated that nature plays an active role in helping people recover from stress and fatigue. Two of the most cited theories in this field are Rachel and Stephen Kaplan's theory of recovery from Directed Attention Fatigue in nature and Roger Ulrich's theory of aesthetic and affective responses to natural environments and stress recovery. One aim of the present study is to test whether being outdoors in a green recreational environment causes people to be more focused, compared to being in a room indoors (in line with hypotheses suggested by the Kaplans). Another aim is to test whether people experience stress reduction, i.e. as evidenced by changes in blood pressure and heart rate, if they are placed in an environment with many green elements (in line with hypotheses suggested by Ulrich). The overall study design is that of an intervention study. Fifteen elderly persons living at a home for very elderly people participated. Their powers of concentration, blood pressure and heart rate were measured before and after an hour of rest in a garden or in an indoor setting. Seven elderly people were randomly chosen to have their first series of tests in a garden, while eight elderly people had their first series of tests indoors. The results indicate that powers of concentration increase for very elderly people after a visit to a garden outside the geriatric home in which they live, compared to that after resting indoors in their favourite room. The results did not show any effects on blood pressure or heart rate. It is suggested that having a one-hour rest outdoors in a garden setting plays a role in elderly people's powers of concentration, and could thereby affect their performance of activities of daily living. One important factor in this study was that both the outdoor environment and the indoor environment at the home were highly valued by participants.     

Changes in the perceived duration of a narrowband sound induced by a preceding stimulus.

The authors show that a narrowband noise (NBN) is perceived as longer when presented immediately after a wideband noise (WBN), compared to when the WBN is absent. This effect depended on the WBN’s frequency spectrum overlapping that of the NBN, and it increased as the duration of the WBN increased up to 300 ms. It decreased when a silent gap was introduced between the WBN and NBN, but remained significant for an easily detectable gap of 40 ms. A correlate of the effect was observed in the mismatch negativity (MMN) to a deviant stimulus, consisting of a WBN + NBN, presented in a sequence of more common isolated WBNs. The MMN latency was longer for an on-frequency than for an off-frequency WBN; and, more importantly, the size of this difference correlated across participants with the difference in perceived duration. A rhythm-adjustment experiment showed that the presence of an on-frequency WBN immediately preceding a tone caused that tone to be heard as starting earlier than when the WBN was absent. The results are discussed in relation to the continuity illusion and models of duration encoding. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Low-voltage terahertz quantum-cascade lasers based on LO-phonon-assisted interminiband transitions

A report is presented on GaAs/(Al,Ga)As terahertz (THz) quantum-cascade lasers (QCLs) based on alternating photon and longitudinal optical (LO) phonon-assisted transitions between quasi-minibands. The design is optimised for low threshold current densities and low operating voltages, resulting in reduced ohmic heating during continuous-wave (CW) operation. The QCLs exhibit lasing over a broad range of frequencies from 2.91 to 3.21 THz. Using single-plasmon waveguides, pulsed operation up to 114 K and CW operation up to 65 K has been achieved.     

Effect of gate length in InAs/AlSb HEMTs biased for low power or high gain

The effect of gate-length variation on DC and RF performance of InAs/AlSb HEMTs, biased for low DC power consumption or high gain, is reported. Simultaneously fabricated devices, with gate lengths between 225 nm and 335 nm, have been compared. DC measurements revealed higher output conductance g_ds and slightly increased impact ionization with reduced gate length. When reducing the gate length from 335 nm to 225 nm, the DC power consumption was reduced by approximately 80% at an f_T of 120 GHz. Furthermore, a 225 nm gate-length HEMT biased for high gain exhibited an extrinsic f_T of 165 GHz and an extrinsic f_max of 115 GHz, at a DC power consumption of 100 mW/mm. When biased for low DC power consumption of 20 mW/mm the same HEMT exhibited an extrinsic f_T and f_max of 120 GHz and 110 GHz, respectively.     

The relation between perceived sensory dimensions of urban green space and stress restoration

Research indicates a relationship between sensory perception of natural environments and human health. Our hypothesis is that people perceive green spaces in terms of certain dimensions, where some dimensions are more important and preferred than others with respect to restoring people from stress.The aims are to: identify and describe the perceived dimensions in nature; identify which dimensions people in general prefer; identify the dimensions people reporting stress prefer; and identify a combination of the dimensions people reporting stress prefer.A total of 953 randomly selected informants from nine Swedish cities (representative of the Swedish population) answered a postal questionnaire with pre-coded questions. The questionnaire consisted of three parts: personal data, preferences for natural qualities and self-estimations of health status. The data were analyzed using factor analysis and regression analyses.The results identify and describe eight perceived sensory dimensions. People in general prefer the dimension Serene, followed by Space, Nature, Rich in Species, Refuge, Culture, Prospect and Social. The dimensions Refuge and Nature are most strongly correlated with stress, indicating a need to find the most restorative environments. A combination of Refuge, Nature and Rich in Species, and a low or no presence of Social, could be interpreted as the most restorative environment for stressed individuals.From a city planning perspective, the results indicate how urban green spaces can be viewed as elements of importance to public mental health. However, before the dimensions can be used by practitioners as tools to promote health through city planning, more research is needed.     

Engineering the S1' subsite of trypsin: design of a protease which cleaves between dibasic residues

The serine protease trypsin was converted into a site-specific protease which hydrolyzes peptides between dibasic residues. Trypsin exhibits a high S1 specificity for Arg and Lys residues. However, the S1' specificity of trypsin is very broad, with only a slight preference for hydrophobic residues in P1'. We replaced Lys60 with Glu and Asp to introduce a high specificity for basic residues into the S1' site of trypsin. Both mutations cause a dramatic increase in the S1' specificity for Arg and Lys as measured by acyl transfer reactions. In K60E, the preference for Arg increases 70-fold while the preference for P1'-Lys increases 12-fold. In contrast, the preferences for other P1' residues either decrease slightly or remain the same. Thus, K60E prefers P1'-Arg over most other P1' residues by 2 orders of magnitude. Similar results are obtained when P1' specificity is measured in peptide cleavage assays. K60D exhibits an S1' specificity profile very similar to that of K60E, although the P1'-Arg preference is reduced by a factor of 2.5. Molecular modeling studies suggest that the high S1' specificity for Arg in K60E may be due to the formation of a salt bridge between Glu60 and the P1'-Arg of the substrate.