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1.
S Grand 《Canadian Metallurgical Quarterly》1995,43(3):741-764
Leo Stone's "The Widening Scope of Indications for Psychoanalysis" has had a major influence on the way almost two generations of American psychoanalysts have been taught to think about and practice psychoanalysis. Contemporary elaborations and extensions of the ideas contained in Stone's paper have, however, been used to move us steadily toward a shift in the treatment paradigm that underlies the way psychoanalysis is currently being conducted. This contemporary tendency to enlarge the scope of the mode of action of psychoanalysis, in order to accommodate the wider range of patients being treated today, blurs those aspects of psychoanalytic technique that distinguish the unique psychoanalytic perspective from the more general psychotherapeutic perspective. Several ideas contained in Stone's paper are considered as a basis for clarifying this distinction and the technical implications deriving from it. Two clinical vignettes are presented to illustrate these issues. 相似文献
2.
Pouliquen M. Denoual M. Jorel C. Radu C. Robbes D. Grand J. Awala H. Mintova S. Harnois M. Sagazan O. de Inoue S. Lebrasseur E. Yamada K. Okamoto Y. Mita-Tixier A. Mita Y. 《Microsystem Technologies》2022,28(6):1313-1319
Microsystem Technologies - We demonstrate a new operation mode of thermal gas sensor based on thermal capacity extraction with identification algorithm. The system is a silicon microstructure... 相似文献
3.
F. Tardy M. Treilles E. Gay C. Ambroset A. Tricot C. Maingourd J. Vialard D. Le Grand 《Journal of dairy science》2019,102(6):5379-5388
Surveillance and control of Mycoplasma spp. responsible for contagious agalactia (CA) in caprine herds are important challenges in countries with a large small-ruminant dairy industry. In the absence of any clinical signs, being able to determine the potential circulation of mycoplasmas within a herd could help to prevent biosecurity issues during animal exchanges between farms and improve health management practices. The objective of this study was to determine whether regular sampling of bulk tank milk was suitable for such surveillance. Twenty farms were sampled once a month for 2 yr and CA-responsible mycoplasmas were detected by real-time PCR on DNA extracted from milk, using 3 different DNA extraction methods. The pattern of mycoplasma excretion in bulk tank milk was assessed over time and several herd characteristics were recorded together with any event occurring within the herds. In general, the results obtained with the different detection methods were comparable and mainly agreed with the culture results. Several patterns of excretion were observed but were not related to herd characteristics (size, breed, and so on). Recurrence of the same (sub)species and same pulsed-field gel electrophoresis subtype during the 2-yr period is indicative of the considerable persistence of mycoplasmas. This persistence was associated with intermittent excretion. In conclusion, bulk tank milk sampling could be valuable for controlling CA in caprine herds provided it is repeated several times, yet to be defined, per year and analyzed using an appropriate methodology and the right cut-off for interpretation. 相似文献
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D Grandér R Hultcrantz O Weiland B Xu O Sangfelt AC Bj?rklund R Befrits M Bj?rkholm A Gruber N Kinnman O Reichard A Widell S Einhorn 《Canadian Metallurgical Quarterly》1996,31(6):604-611
BACKGROUND: The mechanism behind the antiviral action of interferon (IFN) therapy in chronic hepatitis C virus (HCV) infection is not well understood, and, furthermore, few factors have been shown to be good predictors of a favourable response to IFN treatment in chronic HCV infection. METHODS: Freshly explanted liver cells and peripheral blood mononuclear cells (PBMC) from 80 patients with chronic HCV infection were used to study the capacity of IFN to induce the enzyme 2',5'-oligoadenylate synthetase (2'5'-AS) in vitro. The HCV genotype was determined in 53 patients. The induction of 2'5'-AS was correlated to the results of IFN-alpha treatment in 36 patients. RESULTS: Normalization of transaminases during IFN treatment was significantly associated with 2'5'-AS levels in liver cells cultured in the absence of IFN. A similar tendency, although not statistically significant, was found for IFN-induced levels of 2'5'-AS in liver cells. No such associations were found when PBMC were analysed. Six patients showed a sustained biochemical response. These six did not deviate significantly from the remaining patients with regard to base-line or IFN-induced levels of 2'5'-AS in liver cells or PBMC. Eradication of HCV RNA during IFN treatment did not correlate with 2'5'-AS levels in liver cells. Comparison of HCV genotype and clinical response showed that patients with genotype 3a had the most favourable outcome. No association was found between liver histology and treatment outcome. CONCLUSION: These data imply that direct effects of IFN on liver cells are of importance for the response to IFN treatment. 相似文献
6.
Grand Sheldon A.; Bernier Joseph E.; Strohmer Douglas C. 《Canadian Metallurgical Quarterly》1982,27(3):165
191 nondisabled 18–64 yr olds completed the Disability Social Relationship Scale, which includes social situation subscales of Work, Dating, and Marriage, and disability subscales of Amputee, Epilepsy, Cerebral Palsy, and Blind. Results reveal significant differences across social situations and among specific disabilities, as well as a significant interaction between social situation and disability. Thus, situational context affects attitudes toward disabled persons. (26 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
7.
天津牌荧光缩影医用X射线胶片是一种正色性、高感光度,中等反差,细颗粒,单面涂布感光层的胶片,专门适用于拍摄X射线间接摄影机荧光屏上的图像,其生产过程采用一系列先进而精密复杂的工艺技术,如:计算机控制双注法乳化,特殊晶型卤化银颗粒,新型化学增感技术,高速光学增感剂,新型坚膜剂等,因此其质量可与一些世界名牌产品媲美。 相似文献
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Abderrahmane Aït Kaddour Evane Grand Nathalie Barouh Bruno Bara Pierre Villeneuve Bernard Cuq 《European Journal of Lipid Science and Technology》2006,108(12):1037-1046
The present study was aimed at determining the ability of near‐infrared (NIR) spectroscopy to in situ describe fat oxidation kinetics in three different cereal‐based products: salted crackers (20% saturated palm oil and lauric oil, sprayed on surface); healthy crackers (10% unsaturated rapeseed oil, homogeneously distributed inside the product matrix); and moist pasteurised Asian noodles (1.5% unsaturated rapeseed oil, sprayed on surface). Products were stored under accelerated oxidation conditions at 40 °C. Lipid oxidation rates were determined from peroxide value (PV) measurements. We observed no significant changes in PV for the dry crackers (3 meq/kg after 60 days), a slight linear increase in PV for the healthy crackers (40 meq/kg after 60 days), and a rapid increase for the Asian noodles (80 meq/kg after 20 days). The NIR spectra were recorded between 1000 and 2500 nm by using a Fourier Transform NIR spectrometer, using an external probe. Measurements were done directly in situ on the product, on the ground samples, and on the extracted fat phase. The analysis of NIR spectral data by PLS statistical methods demonstrated some correlation trends (R2 = 0.575–0.897; RMSEC = 17–55%) for the products having a significant increase in PV. It was not possible to propose predictive models to calculate the oxidation rate. 相似文献
10.
M Heyman D Grandér K Br?ndum-Nielsen Y Liu S S?derh?ll S Einhorn 《Canadian Metallurgical Quarterly》1993,54(5):748-753
A restriction fragment length polymorphism (RFLP) analysis of the alpha- and beta-interferon (IFN) genes was performed in malignant cells from 52 patients with acute lymphocytic leukemia (ALL). Normal cell DNA was available for comparison in 23 of the patients. Ten patients were found to have gross alterations of their alpha- and beta-IFN genes. Leukemic cells from 2 ALL patients showed a complete loss of alpha- and beta-IFN genes. Seven patients had a hemizygous loss of one of the alpha- and beta-IFN alleles, as shown by RFLP analysis and/or loss of signal intensity. In one other patient the malignant clone was reduced to homozygosity with regard to the alpha- and beta-IFN genes, without loss of signal intensity. In patients without hemizygous deletions, the overall incidence of complete homozygosity for the alpha- and beta polymorphisms was higher than expected. Analysis of the data indicates that the total frequency of ALL clones with gross alterations of the IFN-loci is around 30%. A 9p24 probe detected hemizygous deletions in 2 cases of IFN gene deletions. In the other tested cases the deletions were interstitial. No deletions of 9p24 were detected in patients without allelic losses of IFN genes. In 5 cases of allelic IFN gene deletions, DNA from parents was available for comparison. In 4 cases the deleted allele was derived from the mother, whereas in the fifth it originated from the father. Pediatric ALL patients with IFN-gene deletions or homozygosity for all polymorphisms in the IFN-loci had a significantly worse prognosis than heterozygotes. We conclude that deletion of alpha- and beta-IFN genes is a relatively common event in ALL and that RFLP analysis of the IFN genes may provide additional prognostic information in childhood ALL. Whether or not the IFNs act as tumor-suppressor genes in this disease is not yet known. 相似文献