Across the great divide [global trading system]

Some 30 or 40 years ago, when computers were becoming established in business and government, these new machines drew complaints from people who disliked the standardization that they imposed. Global trade has indeed destroyed local industries but, at the same time, it has generally given the world a higher standard of living. Like the computer age, the era of global trade has come with a new sense of standardization. Trade agreements are technical documents that include lengthy sections of technical definitions, rules, and standards. Hence, it is probably not surprising that the goods and services that have moved most easily from economy to economy and from culture to culture are those that are easily standardized.     

The Best Deal in Town [Supercomputers]

At one time, supercomputing, a term that was synonymous with the Cray-1, was considered to be the best deal in town. However, by the 1990s, manufacturers began to question the need to continue the development of high-speed computers, turning their attention instead to the potential for developing a "high-capacity and high-speed national research and education computer network."     

Development of a collaborative CAD/CAM system

This paper presents the development of a collaborative CAD/CAM system (COCADCAM). COCADCAM extends an existing single-location CAD/CAM system to a multi-location CAD/CAM application so that two geographically dispersed CAD/CAM users can work together on a three-dimensional CAD-geometry coediting and CAD-related tasks collaboratively and dynamically. COCADCAM dynamically supports CAD data communication that are not available in traditional single-location CAD/CAM. The dynamic data communication is achieved through the development of networking algorithms and CAD/CAM functions in this paper. The networking algorithms based on UNIX Interprocess Communication (IPC), the Network File System (NFS), and a connection-oriented client and server model under the Transmission Control Protocol/Internet Protocol (TCP/IP) suite. The CAD/CAM functions included surface modelling, simulation of a milling toolpath, and post-processing of an NC program following collaborative CAD-geometry coediting, which are directly or indirectly supported by the Application Programming Interface (API) of the CAD/CAM software. The networking algorithms and CAD/CAM functions together can facilitate an environment for CAD-geometry coediting and related tasks such as design, analysis and manufacture. COCADCAM has been successfully implemented through local area network (LAN) and the Internet; a remote machining cell is also linked so that the generated NC program based on a coedited free-form surface can be used for the physical machining operation. The algorithm proposed by COCADCAM can be referenced for the extension of other single-location CAD/CAM systems to multi-location applications.     

Figures in the Distance

The technologies that we have deployed over the past two decades have given us new ability to manage activities at a distance.     

The Theosophists' Bathroom

The story that takes India from the electrical infrastructure of 1966 to a modern infrastructure 40 years later is a parable for the free market.     

A social history of Bitnet and Listserv, 1985-1991

After the engineers had built computer networks, users had to build the social networks that made them useful. Listserv, the combined mailing list and file server, was an important tool for those interested in building network-based organizations. It first appeared on Bitnet, an academic network based on IBM computers. The early versions of Listserv became operational in the mid-1980s and its early archives show how network users learned to use the software and, perhaps more importantly, how to manage network-based organizations     

The BAX PCR assay for screening Listeria monocytogenes targets a partial putative gene lmo2234

The BAX PCR for screening Listeria monocytogenes is a commercial PCR assay for specifically targeting L. monocytogenes, a foodborne pathogen that can contaminate a variety of foods and cause a potentially fatal disease, listeriosis, among high-risk populations. The high specificity (> 98%) of this PCR assay is achieved by targeting a species-specific genomic region (approximately 400 bp) presumably found only in L. monocytogenes. In this study, the identity of the BAX PCR-targeted genomic region was determined by using PCR cloning, DNA sequencing, and basic local alignment search tool (BLAST) analysis of the amplicon sequences of an L. monocytogenes serotype 1/2a strain. BLAST analysis identified the BAX PCR amplicon (GenBank accession no. AY364605) as a 423-bp genomic region between nucleotides 224,409 and 224,831 in the genome of L. monocytogenes (serotype 1/2a strain EGD-e), including a 145-bp noncoding region and a 278-bp partial coding sequence of a putative gene, lmo2234. The translated amino acid sequence (92 amino acids) of this partial coding region is highly conserved between L. monocytogenes and Listeria innocua (93% homology). Reverse-position-specific BLAST analysis identified a conserved domain in Lmo2234 that was similar (95.3% aligned, E value = 9E-18) to the consensus amino acid sequence of sugar phosphate isomerases/epimerases (National Center for Biotechnology Information conserved domain database accession no. COG 1082.1, IolE), indicating that Lmo2234 might be involved in bacterial carbohydrate transport and metabolism.