Outcome among patients with acute renal failure needing continuous renal replacement therapy: A single center study

Outcome of acute renal failure (ARF) and use of continuous renal replacement therapy (CRRT) have shown a consistently high mortality. (1) Evaluate the short-term patient survival. (2) Evaluate dialysis-free survival. (3) Evaluate risk factors associated with overall survival and the continued need for intermittent dialysis. We identified adults (≥18 years) needing CRRT, treated in the critical care units of Froedtert Medical and Lutheran Hospital from January 1, 2003 till December 31, 2005. Patients were divided into two major groups needing CRRT, end stage renal disease (ESRD) (chronic dialysis) and non-ESRD with ARF. Continuous renal replacement therapy was performed with an average of 2 L replacement fluid exchanges/h. Sigma stat software was used for analysis. Comparison was done for noncontinuous variables by chi-square and t test for categorical and continuous variables, respectively. A total of 110 (ESRD 24/non-ESRD 86) patients received CRRT during study period. Over all in-hospital mortality among non-ESRD patients was 63% vs. 46% for ESRD. Among non-ESRD patients who survived, 47% needed intermittent hemodialysis on intensive care unit discharge and 28% continued to need hemodialysis at last follow-up. Among non-ESRD patients alive at discharge, those who were dialysis dependent on last follow-up were older (64.5) than those who did not require dialysis on last follow-up (58.4) P=0.347. Non-ESRD patients who died were in the hospital for an average of 17.5 days compared with 29 days for those who were discharged from the hospital. Patients with ARF needing CRRT have high in-hospital mortality. A significant percentage of patients remained dialysis dependant on last follow-up.     

Efficient Window Block Retrieval in Quadtree-Based Spatial Databases

An algorithm is presented to answer window queries in a quadtree-based spatial database environment by retrieving all of the quadtree blocks in the underlying spatial database that cover the quadtree blocks that comprise the window. It works by decomposing the window operation into sub-operations over smaller window partitions. These partitions are the quadtree blocks corresponding to the window. Although a block b in the underlying spatial database may cover several of the smaller window partitions, b is only retrieved once rather than multiple times. This is achieved by using an auxiliary main memory data structure called the active border which requires O(n) additional storage for a window query of size n×n. As a result, the algorithm generates an optimal number of disk I/O requests to answer a window query (i.e., one request per covering quadtree block). A proof of correctness and an analysis of the algorithm's execution time and space requirements are given, as are some experimental results.     

Spectral modelling of multicomponent landscapes in the Sahel

Abstract

Certain landscapes in the Sahel and elsewhere consist of a ‘checkerboard’ arrangement of vegetated and non-vegetated areas in which there may be several spectrally distinct vegetation and bare ground components. When individual components form large spatially coherent patches, and the vertical dimension of the vegetation is small, spectral interactions between components are negligible. The influence of any one component on the average reflectance of the landscape can then be described by its spectral properties and relative area using simple additive mixture models. These models can be extended to the vegetation indices. The spatial average normalized difference vegetation index (NDVI) is a function of the brightness (red plus near-infrared reflectances), the NDVI and the fractional cover of the components. In landscapes where soil and vegetation can be considered the only components, the NDVI-brightness model can be inverted to obtain the NDVI of the vegetation. Aerial photoradiometer data from Mali, West Africa were used to determine the red and near-infrared component reflectances of soil and vegetation. The derived soil component reflectances were well correlated with ground measurements. The relationship between the vegetation component NDVI and plant cover was better than between the NDVI of the entire landscape and plant cover. The usefulness of this modelling approach depends on the existence of clearly distinguishable landscape components. The method resolves the spectral properties of individual components, but the vegetation component, while free of the effect of bare ground components, is still affected by the underlying soil.     

Pictorial Query Specification for Browsing Through Spatially Referenced Image Databases

A pictorial query specification technique that enables the formulation of complex pictorial queries for browsing through a collection of spatially referenced images is presented. It is distinguished from most other methods by the fact that in these methods the query image specifies a target database image in its entirety whereas in our approach the query image specifies the combination of objects that the target database image should contain rather than being treated as a whole image. The query objects are represented by shape features although other features such as color, texture or wavelets could also be used. Using our technique, it is possible to specify which particular objects should appear in the target images as well as how many occurrences of each object are required. Moreover, it is possible to specify the minimum required certainty of matching between query-image objects and database-image objects, as well as to impose spatial constraints that specify bounds on the distance between objects and the relative direction between them. These spatial constraints can also be used to specify other topological relations such as enclosure, intersection, overlap, etc. Each pictorial query is composed of one or more query images. Each query image is constructed by selecting the required query objects and positioning them according to the desired spatial configuration. Boolean combinations of two or more query images are also possible by use of AND and OR operators. A query image may be negated in order to specify conditions that should not be satisfied by the database images that are retrieved successfully. In addition, a capability is provided to specify whether the same instance of an object is to be used when it appears in more than one of the query images that make up the pictorial query, or whether two different instances are allowed. Several example queries are given that demonstrate the expressive power of this query specification method. An algorithm for retrieving all database images that conform to a given pictorial query specification is presented. The user interface for using this pictorial query specification method to browse the results in a map image database application is described and illustrated via screen shots.     

Anti-inflammatory and antioxidant potential capacities of AD-MSCs and BM-MSCs in suppressing pancreatic β-cells auto-immunity and apoptosis in rats with T1DM induced model

Since Type 1 diabetes (T1DM) occurs when β-cells mass is reduced to less than 20% of the normal level due to autoimmune destruction of cells resulting in the inability to secrete insulin, preservation or replenishment of the functional β-cells mass has become a major therapeutic focus for this diabetic type treatment. Thus, this 4-week work plan was designed to determine which mesenchymal stem cells (MSCs) type is more appropriate to alleviate pancreatic hazards resulting from diabetes induction; via tracking a comparative study between MSCs derived from adipose tissue (AD-MSCs) and from bone marrow (BM-MSCs) in management of T1DM considering their immunomodulatory, anti-apoptotic and antioxidative roles. Rats were divided randomly into 4 groups; control, STZ-diabetic (D), D+AD-MSCs, and D+BM-MSCs groups. Both stem cells types in this study were allogenic. Herein, both oxidative stress and antioxidant markers were evaluated using colorimetric analysis, while inflammatory, immune and apoptotic markers were assessed through flow cytometric analysis. Results showed that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited marked pancreatic antioxidant and anti-inflammatory activities that were able to initiate pancreatic immunomodulation and reducing β-cells apoptotic death, thus, help to restore their normal insulin secretion and hypoglycemic abilities. However, AD-MSCs injection was shown to be superior as a pancreatic regenerative tool in overcoming diabetes; owing to their marked antioxidant, anti-inflammatory, immunomodulatory, and anti-apoptotic characteristics over BM-MSCs treatment.     

Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’ tissues

Diabetes mellitus (DM) could negatively affect patients’ health via inducing a lot of serious functional hazards in many tissues’ cells at molecular levels. Recently, many scientists had proposed stem cell therapy being an appropriate alternative treatment protocol for numerous health threatening issues including diabetes. Therefore, the current study was designed to investigate the antioxidant potentiality of two MSCs types in alleviating tissues’ oxidative stress dramatic elevation resulting as a consequence of Type 1 DM induction. In our 4 weeks study, animals were divided into four groups: control group, STZ-diabetic group (D), D+AD-MSCs group and D+BM-MSCs group. Data reported that diabetic rats treated with either AD-MSCs or BM-MSCs exhibited a marvelous body tissues (Pancreas, Liver and Kidney) enhancing capabilities in attenuating the oxidative stress status; as evidenced by XO, ROS, and MDA levels down-regulation; with a general concomitant elevation in the antioxidants’ content; evidenced by many enzymatic and non-enzymatic antioxidants up-regulation; relative to the diabetic untreated group. Interestingly, comparing both treatments with each other and to control group, most of the measured parameters were reverted back to near normal levels after AD-MSCs injection; which clearly point out their stunning health benefits and superiority as anti-diabetic agent in overcoming different tissues’ complications; owing to their marked cytoprotective and regenerative potentialities.