In this work, we assessed the in-vitro effects of eicosapentaenoic acid (EPA; C20:5n-3) and docosahexaenoic acid (DHA; C22:6n-3) (final concentration, 15 microM) on T cell blastogenesis, interleukin-2 and -4 (IL-2, IL-4) secretion, fatty acid composition and intracellular oxidative status in type I diabetic patients with or without complications. Con A stimulated lymphocyte proliferation, glucose uptake, intracellular reduced glutathione levels and catalase activity were lower in diabetics as compared to controls, regardless to the presence of complications. EPA and DHA diminished T-lymphocyte proliferation and IL-2 production but enhanced IL-4 secretion in both diabetic and control groups. No changes in the levels of reduced glutathione and in the activities of catalase and SOD were observed in control T cells cultured in the presence of EPA and DHA. However, in diabetic patients, addition of n-3 PUFA to culture induced an increase in T cell levels of reduced glutathione and hydroperoxide, and in activities of catalase and SOD. Low levels of arachidonic acid (C20:4n-6) were found in plasma membrane phospholipids of lymphocytes from diabetic patients compared to controls. Incubation of lymphocytes with EPA and DHA was associated with an incorporation of these fatty acids in membrane phospholipids. In conclusion, the beneficial effects of n-3 PUFA on T cell functions in type I diabetes could be attributed to their suppressive action and modulation of cytokine secretion, and to the improvement of intracellular oxidative status. 相似文献
Closed-loop control is a basic technology in control engineering. Its role is to avoid the tracking error between set points and real variables. The evaluation of plant performance can be based on multivariate statistical process control connected to closed-loop errors behaviour. Due to its practicality, this approach has found many applications in several industries. This paper suggests a combined use of principal component analysis (PCA) and self-organisation map (SOM) algorithms to evaluate the process on the basis of closed-loop errors dynamic. Generally, it is possible to evaluate a product quality in the basis of the dynamic changes of the closed-loop control errors. In this paper, a new method based on the analysis of the control errors is proposed; it is carried out by a combined use of the PCA-SOM algorithm. Comparatively to the conventional PCA method, this new technique is characterised by the performant indexes that give an accurate evaluation of the process variability and its impact on the product quality. As shown in the different simulation results, the proposed approach gives a global evaluation and improves considerably the performance of computed indexes used for the evaluation of the controlled process. 相似文献
Density functional theory (DFT) is applied to study the structure and electronic properties of oligomers based on bithiophene bridged by a sp2 carbon substituted by a chalcogen atom (O, S, Se and Te), and their polybifurane and polybipyrrole analogues. The important reduction of the energy gap which is observed for the whole series of biheterocyclic compounds, when going down the chalcogen group, is explained on the basis of an orbital interaction analysis. Bithiophene polymers bridged by a selenium or a tellurium substituted carbon atom are expected to exhibit very low energy band gaps. 相似文献
Summary: The powder blend of poly(acrylic acid) (PAA) with zinc oxide or zinc oxide/magnesium oxide was applied successfully to produce zinc polycarboxylate during the 3D dispensing of an aqueous ink by means of 3D printers (Z402? from ZCorporation and Deskmodeler? from bmt Company). The layer‐by‐layer inkjet printing afforded zinc ionomer 3D objects with excellent water resistance, no inherent color formation and high mechanical and dimensional stabilities. In contrast to the 3D printing of conventional powders such as starch/cellulose/dextrose blends, poly(vinyl alcohol) (PVA) or plaster, no postprinting treatments were required. Excellent dimensional accuracy of the models, as evidenced by very small deviation of the dimensions from those of the corresponding CAD data, was achieved. The mechanical properties improved with increasing PAA content, ink amount (saturation value), decreasing particle size of the sintered zinc oxide ceramic. At high PAA content >7 wt.‐%, post‐treatment with aqueous zinc acetate solution improved the mechanical properties. The setting time of the zinc cements shows no significant effect on the mechanical properties, but on the water resistance of the models. The porosity of the 3D objects, measured by means of X‐ray microtomography (μ‐CT), had profound impact on the variations of the mechanical properties of the 3D objects prepared by 3D printing processes.
Comparison of three‐point‐bending tests of commercially available powders with selected zinc cements (ZC1, ZC2, ZC4, ZC19). Commercially available powders printed with recommended values of manufacturer. Zinc cements printed with saturation value 1.14 (Z402?). 相似文献
A method for surface quality evaluation and temperature monitoring of the billet in continuous casting is considered in this paper. This method uses the difference between the measured and the filtered temperature computed using an adaptive support vector machine method. The temperature field, measured by an infrared camera, is affected by an important noise called calamine (a metal oxide generated during the cooling process). The quality of the billet’s surface temperature is connected to the secondary cooling behavior, and therefore an evaluation of the calamine effect is needed. Methods such as soft sensing and adaptive support vector machine are used for a global evaluation of calamine intensity on the monitored area of the billet in continuous casting. This kind of approaches is applied in continuous casting process for constructing a complementary condition monitoring system, which allows an online calamine evaluation. Simulation results, based on the measured surface temperature and the adaptive support vector machine analysis, showed that this new combined approach is easily implementable and gives good results when applied online. 相似文献