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1.
Abstract— A novel green laser source, based on a monolithic cavity microchip laser platform, has been developed. The laser is designed to be a part of a miniature and efficient RGB light source for microdisplay‐based mobile projector devices. The use of highly efficient, periodically poled MgO‐doped lithium niobate as the non‐linear frequency doubler allows for a significant increase in the overall efficiency of the green microchip laser. Specifically, a 50–150‐mW green output with a wall‐plug efficiency exceeding 10% in the temperature range of greater than 40°C has been demonstrated. A compact package for this laser source with a volume less than 0.33 cm3 is discussed and results of performance tests are presented.  相似文献   
2.
This study investigated the extent and nature of university students’ use of digital technologies for learning and socialising. The findings show that students use a limited range of mainly established technologies. Use of collaborative knowledge creation tools, virtual worlds, and social networking sites was low. ‘Digital natives’ and students of a technical discipline (Engineering) used more technology tools when compared to ‘digital immigrants’ and students of a non-technical discipline (Social Work). This relationship may be mediated by the finding that Engineering courses required more intensive and extensive access to technology than Social Work courses. However, the use of technology between these groups is only quantitatively rather than qualitatively different. The study did not find evidence to support popular claims that young people adopt radically different learning styles. Their attitudes to learning appear to be influenced by lecturers’ teaching approaches. Students appear to conform to traditional pedagogies, albeit with minor uses of tools delivering content. The outcomes suggest that although the calls for transformations in education may be legitimate it would be misleading to ground the arguments for such change in students’ shifting patterns of learning and technology use.  相似文献   
3.
Expression of Nodal, a Transforming Growth Factor-beta (TGF-β) related growth factor, is associated with aggressive melanoma. Nodal expression in adult dysplastic nevi may predict the development of aggressive melanoma in some patients. A subset of pediatric patients diagnosed with giant or large congenital melanocytic nevi (LCMN) has shown increased risk for development of melanoma. Here, we investigate whether Nodal expression can help identify the rare cases of LCMN that develop melanoma and shed light on why the majority of these patients do not. Immunohistochemistry (IHC) staining results show varying degree of Nodal expression in pediatric dysplastic nevi and LCMN. Moreover, median scores from Nodal IHC expression analysis were not significantly different between these two groups. Additionally, none of the LCMN patients in this study developed melanoma, regardless of Nodal IHC levels. Co-culture experiments revealed reduced tumor growth and lower levels of Nodal and its signaling molecules P-SMAD2 and P-ERK1/2 when melanoma cells were grown in vivo or in vitro with normal melanocytes. The same was observed in melanoma cells cultured with melanocyte conditioned media containing pigmented melanocyte derived melanosomes (MDM). Since MDM contain molecules capable of inactivating radical oxygen species, to investigate potential anti-oxidant effect of MDM on Nodal expression and signaling in melanoma, melanoma cells were treated with either N-acetyl-l-cysteine (NAC), a component of the anti-oxidant glutathione or synthetic melanin, which in addition to providing pigmentation can also exert free radical scavenging activity. Melanoma cells treated with NAC or synthetic melanin showed reduced levels of Nodal, P-SMAD2 and P-ERK1/2 compared to untreated melanoma cells. Thus, the potential role for Nodal in melanoma development in LCMN is less evident than in adult dysplastic nevi possibly due to melanocyte cross-talk in LCMN capable of offsetting or delaying the pro-melanoma effects of Nodal via anti-oxidant effects of MDM.  相似文献   
4.
The dependence of thermo-mechanical, and mechanical properties on various rare earth dopants (RE) including Nd2O3, Er2O3, and Yb2O3 in 0.4MgF2-0.4BaF2-0.1Ba(PO3)2-0.1Al(PO3)3 glasses (MBBA system) is systematically investigated. MBBA system doped with RE dopants presented the potential application in the field of communication and high power layer system in the previous reports. In this work, it is found that the density of the doped glass increases with an increasing of RE concentration, which could be understood in terms of cationic field strength (CFS) effect. The Knoop hardness is found to decrease with the loading time and dopant concentration due to the indentation size effect (ISE) effect. The observed decrease of thermal expansion coefficient and the increase of glass transition temperature T g with increasing dopant concentration are elucidated in terms of the increasing number of strong covalent bonds with increasing RE dopant concentration. Those results will be of paramount importance before designing optical devices.  相似文献   
5.
Gas chromatographic–electroantennographic detection (GC–EAD) analysis showed that male antennae of the green lacewing, Chrysopa nigricornis Burmeister, the most common lacewing species in the U.S. Pacific Northwest, consistently responded to two compounds in thoracic extracts of conspecific males: 1-tridecene and (1R,2S,5R,8R)-iridodial. These compounds were not detected in extracts of the abdominal cuticle, and no other antennally active compounds were found in the abdominal samples. In field-trapping experiments, traps baited with iridodial significantly attracted large numbers of C. nigricornis males (both western and eastern forms) during summer and early fall, plus a few individuals of conspecific females only in early fall. Iridodial also attracted males of the goldeneyed lacewing, C. oculata Say, and, to a lesser extent, C. coloradensis Banks males. Methyl salicylate (MS), reported as an attractant for both sexes of C. nigricornis and C. oculata, was inactive by itself at the concentration tested in our study, but in a few instances slightly enhanced the responses of Chrysopa spp. to iridodial. However, MS alone and its binary blend with iridodial seemed to attract the hoverfly, Metasyrphus americanus (Weidemann). 2-Phenylethanol, a reported attractant for another lacewing, Chrysoperla plorabunda (Fitch) [=carnea (Say)], did not capture any lacewings. Our assays indicated that the lacewing pheromone, iridodial, loaded onto either rubber septa or as a binary blend with MS in polyethylene bags could last at least 5 wk in the field during the summer season. Based on this study, a new attractant system for green lacewings is being developed for both domestic and international markets.  相似文献   
6.
A new series of 20Bi(PO3)3–10Sr(PO3)2–35BaF2–35MgF2 doped with Yb3+ is introduced for fiber and waveguide laser applications. The stimulated emission cross-section σemi, which was found to be 1.37 pm2 at the lasing wavelength of 996 nm, is the highest one among fluorophosphate glasses. It has been found that an extremely high gain coefficient of G = 1.65 ms pm4 and high quantum efficiency of η = 93% for 1 wt.% Yb2O3 doped systems. The various concentration effects on laser performance properties including minimum pumping intensity Imin, the minimum fraction of excited ions βmin and the saturation pumping intensity Isat are analyzed as a function of Yb2O3 concentration. Those results obtained in current system had advantage over some fluorophosphate glasses reported.  相似文献   
7.
Two sets of Er3+-doped alkaline-free glass systems, MgF2–BaF2–Ba(PO3)2–Al(PO3)3 (MBBA) and Bi(PO3)3–Ba(PO3)2–BaF2–MgF2 (BBBM), have been prepared and investigated with the aim of using them as active media. Radiative lifetimes (τrad) and branching ratios (β) have been obtained for the excited states of Er3+. The absorption spectra were recorded to obtain the intensity parameters (Ωt) which are found to be Ω2 = 4.47 × 10−20 cm2, Ω4 = 1.31 × 10−20 cm2, Ω6 = 0.81 × 10−20 cm2 for the MBBA system and Ω2 = 4.03 × 10−20 cm2, Ω4 = 1.34 × 10−20 cm2, Ω6 = 0.53 × 10−20 for the BBBM system, respectively. The emission cross-section for the 4I13/2 → 4I15/2 transition is determined by the Fuchtbauer–Ladenburg method and found to be 2.35 × 10−20 cm2 and 3.54 × 10−20 cm2 for the MBBA and BBBM system, respectively. Comparison of the measured values to those of Er3+ transitions in other glass hosts suggests that our new glass systems are good candidates for broadband compact optical fiber and waveguide amplifier applications.  相似文献   
8.
Anemia is a commonly observed consequence of whole-body exposure to a dose of X-ray or gamma irradiation of the order of the mean lethal dose in mammals, and it is an important factor for the determination of the survival of animals. The aim of this study was to unravel the effect of laser-driven ultrashort pulsed electron beam (UPEB) irradiation on the process of erythropoiesis and the redox state in the organism. Wistar rats were exposed to laser-driven UPEB irradiation, after which the level of oxidative stress and the activities of different antioxidant enzymes, as well as blood smears, bone marrow imprints and sections, erythroblastic islets, hemoglobin and hematocrit, hepatic iron, DNA, and erythropoietin levels, were assessed on the 1st, 3rd, 7th, 14th, and 28th days after irradiation. Despite the fact that laser-driven UPEB irradiation requires quite low doses and repetition rates to achieve the LD50 in rats, our findings suggest that whole-body exposure with this new type of irradiation causes relatively mild anemia in rats, with subsequent fast recovery up to the 28th day. Moreover, this novel type of irradiation causes highly intense processes of oxidative stress, which, despite being relatively extinguished, did not reach the physiologically stable level even at the 28th day after irradiation due to the violations in the antioxidant system of the organism.  相似文献   
9.
10.
Most important aspect of nanotechnology applications in the information ultrahigh storage is the miniaturization of data carrier elements of the storage media with emphasis on the long-term stability. Proposed two-dimensional ultrahigh-density X-ray optical memory, named X-ROM, with long-term stability is an information carrier basically destined for digital data archiving. X-ROM is a semiconductor wafer, in which the high-reflectivity nanosized X-ray mirrors are embedded. Data are encoded due to certain positions of the mirrors. Ultrahigh-density data recording procedure can e.g., be performed via mask-less zone-plate-array lithography (ZPAL), spatial-phase-locked electron-beam lithography (SPLEBL), or focused ion-beam lithography (FIB). X-ROM manufactured by nanolithography technique is a write-once memory useful for terabit-scale memory applications, if the surface area of the smallest recording pits is less than 100 nm2. In this case the X-ROM surface-storage capacity of a square centimetre becomes by two orders of magnitude higher than the volumetric data density really achieved for three-dimensional optical data storage medium. Digital data read-out procedure from proposed X-ROM can e.g., be performed via glancing-angle incident X-ray micro beam (GIX) using the well-developed X-ray reflectometry technique. In presented theoretical paper the crystal-analyser operating like an image magnifier is added to the set-up of X-ROM data handling system for the purpose analogous to case of application the higher numerical aperture objective in optical data read-out system. We also propose the set-up of the X-ROM readout system based on more the one incident X-ray micro beam. Presented scheme of two-beam data handling system, which operates on two mutually perpendicular well-collimated monochromatic incident X-ray micro beams, essentially increases the reliability of the digital information read-out procedure. According the graphs of characteristic functions presented in paper, one may choose optimally the incident radiation wavelength, as well as the angle of incidence of X-ray micro beams, appropriate for proposed digital data read-out procedure.  相似文献   
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