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排序方式: 共有264条查询结果,搜索用时 15 毫秒
1.
Agenesis of the corpus callosum in a mother and son 总被引:1,自引:0,他引:1
Most reported familial cases of agenesis of the corpus callosum have followed either an autosomal recessive or an X-linked recessive pattern of inheritance. To the best of our knowledge, there is only one previous report of a family showing clear-cut autosomal dominant inheritance. We present the second such family, among whom a mother and her son had moderately severe coordination problems and low-normal intelligence. We suggest that agenesis of the corpus callosum, when transmitted as an autosomal dominant trait, is clinically characterized by a relatively milder phenotype than that occurring when inheritance is either autosomal or X-linked recessive and may be more common than has been thought. 相似文献
2.
Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix: a dosimetric analysis 总被引:1,自引:0,他引:1
JC Roeske AJ Mundt H Halpern P Sweeney H Sutton C Powers J Rotmensch S Waggoner RR Weichselbaum 《Canadian Metallurgical Quarterly》1997,37(2):351-358
OBJECTIVE: The structure of the collagen scar during healing of a myocardial infarction is a determinant of the function of the remodeled tissue. We hypothesize that the passive deformations of both scar and normal tissue are related to the underlying collagen uncoiling as the tissue stretches, and that the unloaded tortuosity of the collagen may be a determinant of tissue stiffness at low ventricular pressure. Hence collagen uncoiling and tissue strain were measured during passive loading in normal tissue, and in healing infarct tissue. METHODS: Left ventricles of rats were infarcted by ligation of the left anterior descending artery for 2 weeks. Surface strains were measured during passive inflation in the scar region in one set of excised hearts, and other arrested hearts were fixed at different ventricular pressures, after which collagen tortuosity was measured in the infarcted and normal tissue. RESULTS: Passive loading strains were smaller in the scar in both the fiber and cross-fiber directions. Tortuosity decreased with load in normal and infarcted tissue, with fibrils tending to straighten more in the scar tissue at higher pressures (1.056 +/- 0.009 vs. 1.024 +/- 0.009 at P = 20 mmHg) with similar tortuosities at zero pressure (1.110 +/- 0.012 vs. 1.098 +/- 0.019). The decrease in tortuosity with strain was greater for the infarcted tissue. CONCLUSIONS: The greater stiffness of infarcted tissue at low pressure is not due to 'straightened' collagen fibers, and there may be a different three-dimensional structure of infarct vs. normal coiled collagen fibers which can affect the material properties of these tissues. 相似文献
3.
A patient who developed a mixed neuroendocrine carcinoma and adenocarcinoma at the site of a previous long-standing ileostomy is reported. The neuroendocrine features are documented by both ultrastructural and immunocytochemical findings. Carcinoma arising in an ileostomy site is rare but has been recorded in patients with long-standing ileostomies after colectomy for chronic inflammatory bowel disease, as in this patient. Neuroendocrine carcinoma developing in this setting apparently has not been described before, however. 相似文献
4.
5.
Advances in technology and changes in necessary workplace skills have made the ability to think critically more important than ever before, yet there is ample evidence that many adults consistently engage in flawed thinking. Numerous studies have shown that critical thinking, defined as the deliberate use of skills and strategies that increase the probability of a desirable outcome, can be learned in ways that promote transfer to novel contexts. A 4-part empirically based model is proposed to guide teaching and learning for critical thinking: (a) a dispositional component to prepare learners for effortful cognitive work, (b) instruction in the skills of critical thinking, (c) training in the structural aspects of problems and arguments to promote transcontextual transfer of critical-thinking skills, and (d) a metacognitive component that includes checking for accuracy and monitoring progress toward the goal. (PsycINFO Database Record (c) 2011 APA, all rights reserved) 相似文献
6.
Watkins SM Lin TY Davis RM Ching JR DePeters EJ Halpern GM Walzem RL German JB 《Lipids》2001,36(3):247-254
Diet and fatty acid metabolism interact in yet unknown ways to modulate membrane fatty acid composition and certain cellular
functions. For example, dietary precursors or metabolic products of n-3 fatty acid metabolism differ in their ability to modify
specific membrane components. In the present study, the effect of dietary 22∶6n−3 or its metabolic precursor, 18∶3n−3, on
the selective accumulation of 22∶6n−3 by heart was investigated. The mass and fatty acid compositions of individual phospholipids
(PL) in heart and liver were quantified in mice fed either 22∶6n−3 (from crocodile oil) or 18∶3n−3 (from soybean oil) for
13 wk. This study was conducted to determine if the selective accumulation of 22∶6n−3 in heart was due to the incorporation
of 22∶6n−3 into cardiolipin (CL), a PL most prevalent in heart and known to accumulate 22∶6n−3. Although heart was significantly
enriched with 22∶6n−3 relative to liver, the accumulation of 22∶6n−3 by CL in heart could not quantitatively account for this
difference. CL from heart did accumulate 22∶6n−3, but only in mice fed preformed 22∶6n−3. Diets rich in non-22∶6n−3 fatty
acids result in a fatty acid composition of phosphatidylcholine (PC) in heart that is unusually enriched with 22∶6n−3. In
this study, the mass of PC in heart was positively correlated with the enrichment of 22∶6n−3 into PC. The increased mass of
PC was coincident with a decrease in the mass of phosphatidylethanolamine, suggesting that 22∶6n−3 induced PC synthesis by
increasing phosphatidylethanolamine-N-methyltransferase activity in the heart. 相似文献
7.
M. Rubin Z. Halpern A. Livoff A. Wennberg A. Tietz E. Antebi D. Lichtenberg 《Lipids》1992,27(5):321-325
This study was undertaken to determine the effect of various lipid emulsions on the hepato-biliary system in rats. Rats were
randomly divided into six groups and infused continuously for 48 hr with either long-chain triglycerides (LCT), medium-chain
triglycerides (MCT) or a mixture of MCT and LCT. One group infused with physiological saline solution served as controls.
Throughout this period the rats received a fat free dietad libitum. During the last hour of lipid infusion bile was collected for determination of bile flow and composition. Subsequently,
the rats were sacrificed and the morphology and lipid content of the liver determined. Only LCT lipid emulsions induced morphological
changes and increased liver cholesterol content. In two rats infused with radiolabeled LCT, no labeled cholesterol was found
in the liver, indicating that the excess hepatic cholesterol level may originate from enhanced cholesterol mobilization to
the liver. Biliary cholesterol and phospholipid concentrations in LCT-treated rats were also elevated, as was the lithogenic
index, whereas the other emulsions had no such effects. None of the emulsions affected the plasma liver function tests or
bile flow. We therefore conclude that the lithogenicity of the bile in rats is directly related to the lipid components of
the total parenteral nutrition and the type of triglyceride infused. 相似文献
8.
Consider a distributed system N in which each agent has an input value and each communication link has a weight. Given a global function, that is, a function
f whose value depends on the whole network, the goal is for every agent to eventually compute the value f (N). We call this problem global function computation. Various solutions for instances of this problem, such as Boolean function computation, leader election, (minimum) spanning
tree construction, and network determination, have been proposed, each under particular assumptions about what processors
know about the system and how this knowledge can be acquired. We give a necessary and sufficient condition for the problem
to be solvable that generalizes a number of well-known results (Attyia et al. in J ACM 35(4):845–875, 1988; Yamashita and
Kameda in IEEE Trans Parallel Distrib Syst 7(1):69–89, 1996; Yamashita and Kameda in IEEE Trans Parallel Distrib Syst 10(9):878–887,
1999). We then provide a knowledge-based (kb) program (like those of Fagin et al. (Reasoning about knowledge, MIT Press, Cambridge, 1995, Distrib Comput 10(4):199–225, 1997))
that solves global function computation whenever possible. Finally, we improve the message overhead inherent in our initial
kb program by giving a counterfactual belief-based program (Halpern and Moses in Distrib Comput 17(2):91–106, 2004) that also solves the global function computation whenever possible,
but where agents send messages only when they believe it is necessary to do so. The latter program is shown to be implemented
by a number of well-known algorithms for solving leader election. 相似文献
9.
We examine four approaches for dealing with the logical omniscience problem and their potential applicability: the syntactic approach, awareness, algorithmic knowledge, and impossible possible worlds. Although in some settings these approaches are equi-expressive and can capture all epistemic states, in other settings of interest (especially with probability in the picture), we show that they are not equi-expressive. We then consider the pragmatics of dealing with logical omniscience—how to choose an approach and construct an appropriate model. 相似文献
10.
We incorporate an arbitrary number of "candidate" positive distinct poles into the scalar l/sub 1/ optimization framework in order to obtain low-order rational suboptimal solutions to constrained l/sub 1/ optimization problems. Our approach uses a single linear program to minimize an upper bound on the l/sub 1/ norm and gives a solution which uses only the best out of the prespecified poles. Rational suboptimal solutions to a scalar two-block problem are obtained similarly. 相似文献