A new TiO2-containing bioactive glass and glass-ceramics based on 50SiO2-(45-X)CaO-(XTiO2)-5P2O5 system was designed using a sol–gel technique (where X = 5, 7.5 and 10 wt %). The roles of the crystallization behavior and physicochemical characteristics of the designed glass and glass-ceramics which were played in the introduction of TiO2 substitutions were investigated. Moreover, cell proliferation and differentiation were evaluated against human osteosarcoma cells (Saos-2). The TiO2/CaO replacements led to the formation of a stronger glass structure and thus increased thermal parameters and the chemical stabilization of the designed materials. The FTIR data confirmed the existence of Ti within the glass and glass-ceramics samples, and no remarkable effect on their chemical integrity was observed. The XRD patterns indicated that calcium-containing minerals, including Ca2SiO4,Ca3(PO4)2, Ca(Ti,Si)O5, CaTiSiO5, and Ca15(PO4)2·(SiO4)6 phases were developed as a role of structure/texture under the applied heat-treatment. The results of the cytotoxicity test proved that a safe sample dose is 12–50 μg/ml, at which cell viability is ≥ 85%. The cell differentiation determined by ALP test proved the superiority of glass-ceramics compared with their native glasses. Therefore, the obtained materials could be safely used as novel biocompatible materials for the regeneration of bone tissue. 相似文献
Surrogate models have been widely applied to correlate design variables and performance parameters in turbomachinery optimization applications. With more design variables and uncertain factors taken into account in an optimization design problem, the mathematical relations between the design variables and the performance parameters might present linear, low-order nonlinear or even high-order nonlinear characteristics, and are usually analytically unknown. Therefore, it is required that surrogate models have high adaptability and prediction accuracy for both the linear and nonlinear characteristics. The paper mainly investigates the effectiveness of an adaptive region segmentation combining surrogate model based on support vector regression and kriging model applied to a transonic axial compressor to approximate the complicated relationships between geometrical variables and objective performance outputs with different sampling methods and sizes. The purpose is to explore the prediction accuracy and computational efficiency of this adaptive surrogate model in real turbomachinery applications. Three different sampling techniques are studied: (1) uniform design; (2) Latin hypercube sampling method; (3) Sobol quasi-random design. For the low dimensional case with five variables, the adaptive region segmentation combining surrogate model performs better (not worse) than the single component surrogate in terms of prediction accuracy and computational efficiency. In the meanwhile, it is also noted that the uniform design applied to the adaptive surrogate model has more advantages over the Latin hypercube sampling method especially for the small sample size cases, both performing better than the Sobol quasi-random design. Moreover, a high dimensional case with 12 variables is also utilized to further validate the prediction advantage of the adaptive region segmentation combining surrogate model over the single component surrogate, and the computational results favor it. Overall, the adaptive region segmentation combining surrogate model has produced acceptable to high prediction accuracy in presenting complex relationships between the geometrical variables and the objective performance outputs and performed robustly for a transonic axial compressor problem.
Seals prepared from acrylonitrile–butadiene rubber (NBR) are primarily used in nuclear services. Nevertheless, at relatively high ionizing radiation doses, NBR seal materials may undergo radiation-induced degradation processes, leading to adverse effects on the sealing ability life. Herein, to strengthen the functional characteristics of NBR seals against radiation, graphene oxide (GO) nanoparticles were prepared and characterized by transmission electron microscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR), and ultraviolet/visible spectroscopies. Various NBR/GO composites fabricated with different ratios of GO nanoparticles and in the presence or absence of carbon black (CB) were investigated via cross-linking density, scanning electron microscopy, XRD, FTIR, and mechanical and thermal stability analyses. The synergistic effect of the simultaneous presence of GO and CB on the NBR seal sensitization to gamma radiation up to a dose of 1 MGy was studied. The physicomechanical properties were enhanced by adding GO nanosheets up to 3 phr and by incorporating 35 phr of a CB with GO until 5 phr. Further, the application of γ-irradiation resulted in an overall enhancement in the mechanical, physical, and thermal stability of the prepared composites up to 0.5 and 1 MGy with GO nanosheets in the absence or presence of CB particles, respectively. The mechanical measurements indicated significant increments by loading with GO nanosheets in the absence and presence of CB as well as by irradiation. The tensile strength elevated up to about 121%, 336%, and 366% by adding 3 phr GO, 3 GO:35 CB phr, and 5 GO:35 CB phr, respectively. 相似文献
We study an online scheduling problem with rejection, in which some rearrangement of the solution is allowed. This problem is called scheduling with rejection and withdrawal. Each arriving job has a processing time and a rejection cost associated with it, and it needs to be either assigned to a machine or rejected upon arrival. At termination, it is possible to choose at most a fixed number of scheduled jobs and withdraw them (i.e., decide to reject them). We study the minimization version, where the goal is to minimize the sum of the makespan and the total rejection cost (which corresponds to the penalty), and the maximization problem, where the goal is to maximize the sum of the minimum load and the total rejection cost (which corresponds to profit). We study environments of machines, which are the case of m identical machines and the case of two uniformly related machines, and show a strong relation between these problems and the related classic online scheduling problems which they generalize, in contrast to standard scheduling with rejection, which typically makes the scheduling problems harder. 相似文献
The MANDAS project has defined a layered architecture for the management of distributed applications. In this paper we examine a vertical slice of this architecture, namely the management applications and services related to configuration management. We introduce an information model which captures the configuration information for distributed applications and discuss a repository service based on the model. We define a set of services and management applications to support maintenance of configuration information, and describe how the different types of configuration information are collected. Finally, we present two management applications that use configuration information. 相似文献
Virus-related hepatocellular carcinoma (HCC) pathogenesis involves liver inflammation, therefore, despite successful treatment, hepatitis C virus (HCV) may progress to HCC from initiated liver cirrhosis. Cytotoxic T cells (Tcs) are known to be involved in HCV-related cirrhotic complications and HCC pathogenesis. The inhibitory checkpoint leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is expressed on Tcs. Therefore, we aimed to determine whether the Tc expression level of LAIR-1 is associated with HCC progression and to evaluate LAIR-1 expression as a noninvasive biomarker for HCC progression in the context of liver cirrhosis related to HCV genotype 4 (G4) in Egyptian patients’ peripheral venous blood liquid biopsy. A total of 64 patients with HCC and 37 patients with liver cirrhosis were enrolled in this case-controlled study, and their LAIR-1 expression on Tc related to the progression of liver cirrhosis was examined and compared to that of the apparently healthy control group (n = 20). LAIR-1 expression was analyzed using flow cytometry. Results: The HCC group had significantly higher LAIR-1 expression on Tc and percentage of Tc positive for LAIR-1 (LAIR-1+Tc%) than the HCV G4-related liver cirrhosis group. LAIR-1+Tc% was correlated with the HCC surrogate tumor marker AFP (r = 0.367, p = 0.001) and insulin resistance and inflammation prognostic ratios/indices. A receiver operating characteristic (ROC) curve revealed that adding LAIR-1+Tc% to AFP can distinguish HCC transformation in the Egyptian patients’ cohort. Upregulated LAIR-1 expression on Tc could be a potential screening noninvasive molecular marker for chronic inflammatory HCV G4 related liver cirrhosis. Moreover, LAIR-1 expression on Tc may be one of the players involved in the progression of liver cirrhosis to HCC. 相似文献
The COVID-19 pandemic has affected the educational systems worldwide, leading to the near-total closures of schools, universities, and colleges. Universities need to adapt to changes to face this crisis without negatively affecting students’ performance. Accordingly, the purpose of this study is to identify and help solve to critical challenges and factors that influence the e-learning system for Computer Maintenance courses during the COVID-19 pandemic. The paper examines the effect of a hybrid modeling approach that uses Cloud Computing Services (CCS) and Virtual Reality (VR) in a Virtual Cloud Learning Environment (VCLE) system. The VCLE system provides students with various utilities and educational services such as presentation slides/text, data sharing, assignments, quizzes/tests, and chatrooms. In addition, learning through VR enables the students to simulate physical presence, and they respond well to VR environments that are closer to reality as they feel that they are an integral part of the environment. Also, the research presents a rubric assessment that the students can use to reflect on the skills they used during the course. The research findings offer useful suggestions for enabling students to become acquainted with the proposed system’s usage, especially during the COVID-19 pandemic, and for improving student achievement more than the traditional methods of learning. 相似文献