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1.
宋继萍 《中国生物制品学杂志》2007,20(9):681-684,687
目的评估免疫细胞素Hu14.18-IL-2对黑色素瘤病人体内免疫作用。方法33位黑色素瘤病人用一种人源化抗神经节苷脂GD-2的单抗与IL-2融合的免疫细胞素进行治疗,按每天0.8、1.6、3.2、4.8、6.0、7.5 mg/m2静脉滴注,连续3 d为一疗程,病情稳定或缓解后,在第5周接受第2疗程治疗。观察病人外周血单核淋巴细胞抗体依赖的细胞毒性、自然杀伤细胞活性、IL-2的体外增殖以及IL-2可溶性受体的变化。结果Hu14.18-IL-2能诱导病人淋巴细胞的吞噬作用,增强外周血中自然杀伤细胞的杀伤能力和数目,使血清中IL-2受体复合体的可溶性受体α链水平上升。结论免疫细胞素Hu14.18-IL-2对黑色素瘤病人具有免疫激活作用。 相似文献
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Reconstructing boundaries along material interfaces from volume fractions is a difficult problem, especially because the under‐resolved nature of the input data allows for many correct interpretations. Worse, algorithms widely accepted as appropriate for simulation are inappropriate for visualization. In this paper, we describe a new algorithm that is specifically intended for reconstructing material interfaces for visualization and analysis requirements. The algorithm performs well with respect to memory footprint and execution time, has desirable properties in various accuracy metrics, and also produces smooth surfaces with few artifacts, even when faced with more than two materials per cell. 相似文献
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The objectives of an organization in combination with the formal policy together underpin the strategic direction that any organization will take. We all know that security begins with policy – in other words the rules of play. If policy is sound then the appropriate security measures can be implemented to protect the activities required to achieve the stated objectives as well as maintain the information assurance requirements – availability, integrity, authentication, confidentiality and non-repudiation. 相似文献
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Compared the effects of signaled and unsignaled shock on the pituitary-adrenal response of 68 male Long-Evans hooded rats. In Exp I, exposure to the 2 procedures yielded no difference in plasma corticosterone levels. In Exp II, the addition of a food-reinforced leverpressing baseline produced conditioned suppression in the signaled condition but no group difference in steroid values. To guard against steroid elevations produced by exposure to shock, blood samples in Exp III were obtained during brief test sessions prior to the occurrence of shock. The procedure resulted in a significant elevation in the steroid levels of the signaled shock group. In Exp IV, a within-Ss sampling procedure revealed that disparate group steroid values obtained earlier in the session had converged by the end of the test session. The final experiment produced the original failure to obtain a steroid difference due to predictability in the absence of a behavioral baseline. Results suggest that (a) the effects of predictability are largely seen in the temporal pattern of steroid elevations and not in their terminal values, (b) the effects of predictability on steroids are modulated by the availability of control, and (c) control is not confined to the stimulus that is being predicted. (36 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Texture mapping is a method commonly used to increase the visual complexity of computer generated images while maintaining simplicity in the underlying geometric models. Texture maps are generally defined in two dimensional space; thus, a primary problem when applying textures to objects is determining a mapping transformation from the three dimensional space of the object to the two dimensional space of the map. A method for mapping complex polygonal geometries is presented. The algorithmunfolds the object polygon by polygon and projects the texture map onto the resulting two dimensional geometry. Enhancements to the basic unfolding algorithm either (1) control the location of map distorition introduced at areas of severe curvature or (2) average distortions over a larger area. 相似文献
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This paper uses four case studies to emphasize the fact that field engineering decisions cannot be made without a full understanding of all the technical problems involved. Two of the studies are taken from conventional design-bid-build projects and two are taken from design-build projects in which the ability to strongly influence design in the interest of construction efficiency places a new and increased emphasis on construction and field engineering skills. The cases also show that field engineering decisions frequently address new and unexpected realities, changed conditions, and transient loads, and thus they require high levels of understanding, technical analysis, and creative thought. We emphasize the need for universities and construction engineering programs to develop graduates who are capable of integrating design and construction considerations throughout the project delivery process. We also urge programs to continue to focus strongly on field engineering as the foundation for success in an increasingly complex and technically driven construction industry. 相似文献
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Building on recent research investigating the role of life-course factors (including childhood conditions) and societal context in older Europeans health status, this study investigates the determinants of changes in elders’ health across two waves of the Survey of Health Ageing and Retirement in Europe (SHARE). Controlling for individuals’ current living conditions at baseline, our analysis provides evidence for long-term associations between childhood conditions (SES, health, cognition) and health dynamics in older age. Moreover, our findings suggest that income inequality tends to increase elders’ risk of experiencing negative health changes (decreases their chance to recover from poor health, respectively). Our study underlines the importance of accounting for both life-course and societal determinants of later life health dynamics. 相似文献
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Hank Kune 《Creativity & Innovation Management》1995,4(3):199-200
E.A.C.I.'s corporate liaison sees co-operation and communication amongst members as one way in which to realize mutual objectives. Exploring these objectives is one of the points on the agenda this autumn in the Association's first corporate Podium. 相似文献