DADE: a fast data anomaly detection engine for kernel integrity monitoring

The Journal of Supercomputing - In computer systems, ensuring the integrity of the kernel assumes importance as attacks against the kernel allow an adversary to obtain the highest privilege within...     

Collision-free Autonomous Navigation of A Small UAV Using Low-cost Sensors in GPS-denied Environments

This paper proposes a novel complete navigation system for autonomous flight of small unmanned aerial vehicles (UAVs) in GPS-denied environments. The hardware platform used to test the proposed algorithm is a small, custom-built UAV platform equipped with an onboard computer, RGB-D camera, 2D light detection and ranging (LiDAR), and altimeter. The error-state Kalman filter (ESKF) based on the dynamic model for low-cost IMU-driven systems is proposed, and visual odometry from the RGB-D camera and height measurement from the altimeter are fed into the measurement update process of the ESKF. The pose output of the ESKF is then integrated into the open-source simultaneous location and mapping (SLAM) algorithm for pose-graph optimization and loop closing. In addition, the computationally efficient collision-free path planning algorithm is proposed and verified through simulations. The software modules run onboard in real time with limited onboard computational capability. The indoor flight experiment demonstrates that the proposed system for small UAVs with low-cost devices can navigate without collision in fully autonomous missions while establishing accurate surrounding maps.

     

A Multiligand Architectural Photosensitizer That Targets Hemagglutinin on Envelope of Influenza Virus for Photodynamic Inactivation

The efficacy of current antiviral drugs used to treat influenza has been declining because of mutations and resistance of the virus. Herein, a light‐sensitive multiligand architecture is developed consisting of chitosan conjugated to a photosensitizer and 6'‐sialyllactose (SL) to develop an antiviral agent against influenza with a different mechanism of action (SL‐chitosan‐Chlorin e6, SCC). Saturation transfer difference‐nuclear magnetic resonance determined that the ability of SCC to bind to viral hemagglutinin is stronger than that of the monomeric substance. Virus recognition is confirmed by immunofluorescence and transmission electron microscope imaging. SCC induces viral inactivation by causing permanent membrane damage through its photoactivity. Viral membrane is oxidized by the photoactivity of SCC, thus, the virus membrane collapses. Furthermore, using the plaque reduction assay to evaluate the inhibitory effect of SCC on influenza A and B, it is found that its antiviral effects are 23% and 50% higher than the conventional antiviral drug. Additionally, SCC prevents infection by influenza in 100% of mice subjected to laser irradiation. These results indicate that this photodynamic multiligand structure can overcome the limitations of existing antiviral agents and suggest a pertinent methodology of prophylaxis and treatment by preemptively attacking the virus before it enters the host cell.     

Rottlerin suppresses lipid accumulation by inhibiting de novo lipogenesis and adipogenesis via LRP6/mTOR/SREBP1C in 3T3-L1 adipocytes

Food Science and Biotechnology - Rottlerin is isolated from Mallotus japonicus, a plant rich in polyphenols. Rottlerin is a selective PKCδ-inhibitor and is also known as an uncoupler of...