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1.
Sarah Gilgunn Keefe Murphy Henning Stckmann Paul J. Conroy T. Brendan Murphy R. William Watson Richard J. OKennedy Pauline M. Rudd Radka Saldova 《International journal of molecular sciences》2020,21(23)
The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression patterns change with the cellular modifications that accompany the onset of tumorigenesis. The aim of this study was to investigate if differential glycosylation patterns could distinguish between indolent, significant, and aggressive PCa. Whole serum N-glycan profiling was carried out on 117 prostate cancer patients’ serum using our automated, high-throughput analysis platform for glycan-profiling which utilizes ultra-performance liquid chromatography (UPLC) to obtain high resolution separation of N-linked glycans released from the serum glycoproteins. We observed increases in hybrid, oligomannose, and biantennary digalactosylated monosialylated glycans (M5A1G1S1, M8, and A2G2S1), bisecting glycans (A2B, A2(6)BG1) and monoantennary glycans (A1), and decreases in triantennary trigalactosylated trisialylated glycans with and without core fucose (A3G3S3 and FA3G3S3) with PCa progression from indolent through significant and aggressive disease. These changes give us an insight into the disease pathogenesis and identify potential biomarkers for monitoring the PCa progression, however these need further confirmation studies. 相似文献
2.
Henning Fernau 《Acta Informatica》1997,34(11):837-857
3.
4.
Henning H. Mikkelsen Jens Oddershede John R. Sabin Ejvind Bonderup 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》1995,100(4):451-457
We derive a Bethe formula for the stopping of swift ions by target molecules oriented with respect to the beam. The theory is characterized by a directional mean excitation energy formed from transition energies and dipole matrix elements. The expression for the mean excitation energy is similar to the one for an isotropic sample but the dipole matrix elements corresponding to the various transition moment directions carry unequal weights which depend on the orientation of the molecule with respect to the beam. For a large class of molecules, the logarithm of the mean excitation energy is linear in sin2 θ, where θ denotes the angle between the beam and the principal molecular axis. We illustrate the properties of the theory in the simple case of a diatomic molecule. 相似文献
5.
Johan P. Hansen Henning Stichtenoth 《Applicable Algebra in Engineering, Communication and Computing》1990,1(1):67-77
We construct a series of algebraic geometric codes using a class of curves which have many rational points. We obtain codes of lengthq
2 over
q
, whereq = 2q
0
2
andq
0 = 2
n
, such that dimension + minimal distance q
2
+ 1 – q
0
(q – 1). The codes are ideals in the group algebra
q
[S], whereS is a Sylow-2-subgroup of orderq
2 of the Suzuki-group of orderq
2
(q
2
+ 1)(q – 1). The curves used for construction have in relation to their genera the maximal number of
GF
q
-rational points. This maximal number is determined by the explicit formulas of Weil and is effectively smaller than the Hasse—Weil bound.Supported by Deutsche Forschungsgemeinschaft while visiting Essen University 相似文献
6.
Werner Strohmaier Henning Klostermeyer Paul Deuritz Erich Windhab 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1992,194(6):531-535
Summary Current texture-measuring instruments and a recently developed measuring method (two-dimensional measuring of the force necessary to spread a sample) were compared in measuring the spreadability of processed cheese. How far subjective assessment by a qualified panel correlates with the instrumental results in determining spreadability and firmness was also investigated. Samples of processed cheese with various consistencies were measured by an Universal testing machine, a buttermeasuring instrument (DIN 10331), a rotational-type rheometer (oscillation mode) and a two-dimensional force measuring instrument. The evaluation of the results shows that an oscillating rheometer is most suitable to measure the spreadability of processed cheese; the correlation coefficient (r) between the dynamic Weissenberg number, calculated from parameters of the rheometer, and the subjective judgement by the panel wasr=0.91. For the determination of firmness the two-dimensional force measuring instrument is most suitable. The correlation coefficient between the parameter tangential energy (S
t) and the sensorially evaluated firmness wasr=0.95.
Vergleich verschiedener Bestimmungsmethoden für die Streichfähigkeit und Festigkeit von Schmelzkäse
Zusammenfassung Verschiedene gebräuchliche Meßinstrumente und ein neu entwickeltes Gerät zur zweidimensionalen Messung der Kräfte, die zum Ausstreichen einer Probe erforderlich sind, wurden vergleichend zur Charakterisierung der Streichfähigkeit von Schmelzkäse erprobt. Dabei wurde auch geprüft, inwieweit die subjektiven Beurteilungen eines qualifizierten Prüferpanels mit den Meßwerten für Streichfähigkeit und Festigkeit korrelierten. Gemessen wurde mit einer Universalprüfmaschine, dem Butterprüfgerät (DIN 10331), einem Rotationsrheometer und mit dem zweidimensional registrierenden Kraftmeßgerät. Dabei zeigte sich, daß das Rheometer im oscillierenden Modus die Streichfähigkeit am besten zu charakterisieren vermag. Die Korrelation zwischen den Rheometerwerten, berechnet als dynamische Weissenbergzahl, und den sensorisch ermittelten Werten für die Streichfähigkeit betrugr=0,91. Zur Bestimmung der Festigkeit ist das zweidimensional registrierende Kraftmeßgerät am besten geeignet, was sich in einem Korrelationskoeffizienten vonr=0,95 zwischen dem ParameterS t und den im Sensoriktest ermittelten Werten für dieFestigkeit ausdrückt.相似文献
7.
TIBER II is designed to be a minimum size and cost candidate for an international Engineering Test Reactor. High-current density Nb3Sn superconducting magnets with radiation-tolerant polymide insulation is combined with a minimum thickness tungsten inbored shield and a common, external vacuum boundary to minimize the inner radial build of the tokamak core. This results in a major radius of 3 m, compared to 5 m for previous ETR designs such as INTOR, with correspondingly lower costs expected. Cyclic stress fatigue limits the number of pulses so that steady-state current drive, based on a combination of neutral beams, lower hybrid and ECH, is designed to achieve reactor-relevant nuclear testing conditions (Fluence 3MW yr/m2, rwall > 1 MW/m2 in steady state).This report is abstracted from a more complete information document UCID-20863 with numerous authors. See Ref. l for complete credits. 相似文献
8.
Activated carbon is a suitable adsorbent for removal of hydrogen sulphide from natural, synthesis or other product gases. The process depends predominantly on physical adsorption, though catalytic oxidation is also involved. During catalytic oxidation the H2S is converted in the presence of oxygen to elemental sulphur, which is adsorbed onto the internal surface of the activated carbon, thus leading to a sulphur load of up to 120% by weight. The oxidation rate depends on the partial pressure of both reactants, H2S and O2 and is largely controlled by the characteristics of the activated carbon. The activity of the catalyst can be improved by impregnating the activated carbon with promoters such as iron and iodine. The regeneration of spent carbon is currently carried out using hot gas desorption methods at temperatures around 450 °C. 相似文献
9.
André F. van Rooyen Peter Ramshaw Martin Moyo Richard Stirzaker Henning Bjornlund 《国际水资源开发杂志》2017,33(5):804-823
AbstractMany small-scale irrigation systems are characterized by low yields and deteriorating infrastructure. Interventions often erroneously focus on increasing yields and rehabilitating infrastructure. Small-scale irrigation systems have many of the characteristics of complex socio-ecological systems, with many different actors and numerous interconnected subsystems. However, the limited interaction between the different subsystems and their agents prevents learning and the emergence of more beneficial outcomes. This article reports on using Agricultural Innovation Platforms to create an environment in which irrigation scheme actors can engage, experiment, learn and build adaptive capacity to increase market-related offtake and move out of poverty. 相似文献
10.