Staphylococcus aureus Infection-Related Glomerulonephritis with Dominant IgA Deposition

Since 1995, when we reported the case of a patient with glomerulonephritis with IgA deposition that occurred after a methicillin-resistant Staphylococcus aureus (MRSA) infection, many reports of MRSA infection-associated glomerulonephritis have accumulated. This disease is being systematized as Staphylococcus infection-associated glomerulonephritis (SAGN) in light of the apparent cause of infection, and as immunoglobulin A-dominant deposition infection-related glomerulonephritis (IgA-IRGN) in light of its histopathology. This glomerulonephritis usually presents as rapidly progressive glomerulonephritis or acute kidney injury with various degrees of proteinuria and microscopic hematuria along with an ongoing infection. Its renal pathology has shown several types of mesangial and/or endocapillary proliferative glomerulonephritis with various degrees of crescent formation and tubulointerstitial nephritis. IgA, IgG, and C₃ staining in the mesangium and along the glomerular capillary walls have been observed on immunofluorescence examinations. A marked activation of T cells, an increase in specific variable regions of the T-cell receptor β-chain-positive cells, hypercytokinemia, and increased polyclonal immune complexes have also been observed in this glomerulonephritis. In the development of this disease, staphylococcal enterotoxin may be involved as a superantigen, but further investigations are needed to clarify the mechanisms underlying this disease. Here, we review 336 cases of IgA-IRGN and 218 cases of SAGN.     

Context-Based Network and Application Management on Seamless Networking Platform

A context-based adaptive communication system is introduced for use in heterogeneous networks. Context includes the user's presence, location, available network interfaces, network availability, network priority, communication status, terminal features, and installed applications. An experimental system was developed to clarify the feasibility of using context information to flexibly control networks and applications. The system operates on a seamless networking platform we developed for heterogeneous networks. By using contexts, the system can inform the caller and callee of applications they can access, which are available through the network before communication occurs. Changes in contexts can switch an on-going application to another during actual communication. These functions provide unprecedented styles of communication. A business scenario for a seamless networking provider is also presented. Dr. Morikawa has also been in charge of NICT's Mobile Networking Group. Masugi Inoue received his B.E. from Kyoto University in 1992 and his M.E. and D.E. from the University of Tokyo in 1994 and 1997, all in the field of Electrical Engineering. He is currently a senior researcher at the Yokosuka Radio Communications Research Center under the National Institute of Information and Communications Technology (NICT), Japan, and has been engaged in R&D on ultrahigh-speed WLANs and mobile networking. He joined the Communications Research Laboratory (CRL) of the Ministry of Posts and Telecommunications, Japan, in 1997, which was reorganized as NICT in April 2004. He was a visiting researcher at Polytechnic University in Brooklyn, New York in 2000. Khaled Mahmud received his B.Sc. (Eng.) in Electrical and Electronics Engineering from the Bangladesh University of Engineering and Technology in Dhaka in 1991. He received his M.E. and Ph.D. in the same field from Shizuoka University in Japan, in 1997 and 2000, respectively. He was a research fellow at NICT, Japan, from 2000 to 2004. He is currently an Assistant Professor in the Department of Computer Science and Engineering at North South University, Bangladesh. His research interests include modulation-demodulation techniques, software radio, mobile communication systems, wireless Internet, and IP mobility technologies. Homare Murakami received his B.E. and M.E. in Electronic Engineering from Hokkaido University in 1997 and 1999. In 2004, he received the Young Investigators Award from IEICE. He is currently a researcher at NICT's Mobile Networking Group. He is also an industrial PhD student in Aalborg University since 2003. His interest areas are naming scheme, wireless TCP and new transport protocol, IP mobility, fast handover method, and location management. Mikio Hasegawa received his B. Eng, M. Eng., and Dr. Eng. in 1995, 1997, and 2000 from Science University of Tokyo. From 1997 to 2000, he was a Research Fellow of the Japan Society for the Promotion of Science (JSPS). He is currently a senior researcher in Mobile Networking Group, National Institute of Information and Communications Technology, and a technical advisor in ChaosWare Inc. His research interests include applications of chaotic dynamical theory, combinatorial optimization, mobile networks, and ubiquitous computing. Hiroyuki Morikawa received his B.E., M.E., and D.E. in Electrical Engineering from the University of Tokyo in 1987, 1989, and 1992. He is currently an Associate Professor in the Department of Frontier Informatics at the University of Tokyo and is in charge of NICT's Mobile Networking Group. His research interests are in the areas of computer networks, mobile computing/networks, ubiquitous computing, and network services. He serves as Editor of Transactions of the IEICE and has been on the technical program committees of IEEE/ACM conferences and workshops. He sits on numerous telecommunications advisory committees and frequently serves as a consultant to the government.     

基于模糊聚类的信任类型动态定义机制研究

从主观信任的本质出发,提出了基于Agent的主观信任协作模型,分析了主体信任协作关系的本质;引入模糊集台理论的隶属度概念,以信任向量的形式对主观信任进行定量的描述,解决了主观信任的建模问题;结合主观信任协作模型,引入模糊聚类理论,提出了基于模糊聚类的信任类氆动态定义机制,为各主体之间的信任评估提供了依据。     

G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells

G protein-coupled receptor 87 (GPR87) is a newly deorphanized member of the cell surface molecule G protein-coupled receptor family. GPR signaling was shown to play a role in promotion of cell growth and survival, metastasis, and drug resistance. The overexpression of GPR87 has also been reported in many malignant tumors including bladder cancer. The aim of the present study is to examine the effect of silencing GPR87 expression with a replication-deficient recombinant adenoviral vector expressing short hairpin RNA targeting GPR87 (Ad-shGPR87) and to explore the underlying molecular mechanisms in bladder cancer cells. Six GPR87-expressing human bladder cancer cells, HT1197, HT1376, J82, RT112, TCCSUP and UMUC3, were used. Infection with Ad-shGPR87 effectively downregulated the GPR87 expression, and significantly reduced the percentage of viable cells in 4 of 6 cell lines as detected by an MTT assay. Significant inhibition on cell proliferation with Ad-shGPR87 was observed in the wild-type p53 bladder cancer cell lines (HT1197, RT112, TCCSUP and UMUC3), but not in the mutant p53 cells (HT1376 and J82). As represented by a wild-type p53 RT112 cell, Ad-shGPR87 infection significantly enhanced p53 and p21 expression and caused caspase-dependent apoptosis. Furthermore, the treatment with Ad-shGPR87 exerted a significant antitumor effect against the GPR87-expressing RT112 xenografts. GPR87 appeared to be a promising target for gene therapy, and Ad-shGPR87 had strong antitumor effects, specifically anti-proliferative and pro-apoptotic effects, against GPR87-expressing human bladder cancer cells.     

Computational and experimental analyses on impact reduction when a humanoid robot lands on the ground

The purpose of this study is to reduce the impact force when a humanoid robot lands on the ground or the floor. First, the landing postures of a human subject were analyzed while measuring the impact forces when the subject lands on the floor. Through the experimentally observed relations between the landing postures and the impact forces, it was hypothesized that a human being may reduce the impact force by motion control of his or her center of gravity, for example, to lengthen the time of the landing motion. Then, a landing robot was developed, and an experiment to measure the impact forces was conducted to prove the hypothesis.     

Expression and Role of GPR87 in Urothelial Carcinoma of the Bladder

The orphan GPR87 has recently been matched with its ligand LPA, which is a lipid mediator with multiple physiological functions, including cancer cell proliferation. This study aimed to clarify the role of GPR87 in urothelial carcinoma of the bladder. GPR87 expression was assessed in seven human bladder cancer cell lines. A replication-deficient recombinant adenoviral vector expressing shRNA targeting GPR87 (Ad-shGPR87), was constructed. Gene silencing was carried out using Ad-shGPR87. Immunohistochemical analysis was performed for transurethral resection of bladder tumor samples from 71 patients with non-muscle-invasive bladder cancer. We observed GPR87 expression in five of the seven cell lines, and silencing GPR87 gene expression significantly reduced cell viability. GPR87 expression was positive in 38 (54%) of 71 tumors. Ki-67 index was associated with positive GPR87 staining status (p < 0.0001). Patients with GPR87-positive tumors had shorter intravesical recurrence-free survival than those with GPR87-negative tumors (p = 0.010). Multivariate analysis revealed that GPR87 staining status was an independent prognostic parameter for intravesical recurrence (p = 0.041). Progression from non-muscle-invasive to muscle-invasive tumor was more frequently observed in patients with GPR87-positive tumors, although this trend did not reach statistical significance (p = 0.056). These results warrant further prospective studies to clarify the role of GPR87 expression in intravesical recurrence and progression in bladder cancer.     

模糊自主信任建立策略的研究

该文首先从分析开放式网络环境中有关信任的问题和主观信任的模糊性入手,以模糊理论为基础,引入隶属度来描述信任的模糊性,解决了模糊信任模型的建模问题;以图论为基础,将网络环境模型化为一个无向图 ,定义了基于本地信息交互的信任评价规则;提出了基于开放式网络环境的模糊自主信任模型,具体研究了自主信任建立策略及建立完全可信网络的实现机制及条件;最后通过仿真实验讨论了网络拓扑结构对自主信任建立的影响,并以小世界网络模型(-model)为基础分析讨论了自主信任建立的速度问题,这为网络管理的研究提供了一个有价值的新思路。