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排序方式: 共有1428条查询结果,搜索用时 31 毫秒
1.
Kazuo Tsubota Stephen C. Pflugfelder Zuguo Liu Christophe Baudouin Hyo Myung Kim Elisabeth M. Messmer Friedrich Kruse Lingyi Liang Jimena Tatiana Carreno-Galeano Maurizio Rolando Norihiko Yokoi Shigeru Kinoshita Reza Dana 《International journal of molecular sciences》2020,21(23)
Over the past decades, the number of patients with dry eye disease (DED) has increased dramatically. The incidence of DED is higher in Asia than in Europe and North America, suggesting the involvement of cultural or racial factors in DED etiology. Although many definitions of DED have been used, discrepancies exist between the various definitions of dry eye disease (DED) used across the globe. This article presents a clinical consensus on the definition of DED, as formulated in four meetings with global DED experts. The proposed new definition is as follows: “Dry eye is a multifactorial disease characterized by a persistently unstable and/or deficient tear film (TF) causing discomfort and/or visual impairment, accompanied by variable degrees of ocular surface epitheliopathy, inflammation and neurosensory abnormalities.” The key criteria for the diagnosis of DED are unstable TF, inflammation, ocular discomfort and visual impairment. This definition also recommends the assessment of ocular surface epitheliopathy and neurosensory abnormalities in each patient with suspected DED. It is easily applicable in clinical practice and should help practitioners diagnose DED consistently. This consensus definition of DED should also help to guide research and clinical trials that, to date, have been hampered by the lack of an established surrogate endpoint. 相似文献
2.
Machine Learning - We consider the problem of learning a binary classifier from only positive and unlabeled observations (called PU learning). Recent studies in PU learning have shown superior... 相似文献
3.
Seasoned beef called Jangzorim in Korea is produced by boiling in soy sauce, and is a popular food in Korea. The aim of this study is to evaluate the microbial safety and physical qualities of sous vide processed seasoned beef, and the effect of nisin during storage. Sous vide processed packages with or without nisin (100 IU or 500 IU) were stored at 4 °C or 25 °C for 60 days, and samples measured for quality at regular intervals throughout this storage period. In the case of 25 °C storage, the number of mesophilic microorganisms in seasoned beef packages without nisin increased markedly, but with nisin there was no observed increase. Psychrotrophic microorganisms, anaerobic microorganisms, and B. cereus cells showed similar trends, although C. perfringens was not detected in all samples. At 25 °C storage, changes in the cutting force of packages containing nisin showed no significant change, packages without nisin decreased markedly. The colour of packages without nisin showed a drastic decrease in lightness (‘L’) while no changes were observed in packages with nisin. 相似文献
4.
Jeong-Woo Choi Jun Hyo Park Shin Chul Lee Dong-Il Kim Won Hong Lee 《Korean Journal of Chemical Engineering》1995,12(5):528-534
The on-line sensing of viable cell weight in plant cell culture process is applied to analysis and control of process. The
fiber-optic fluorescence sensor was constructed to measure the NADH-dependent fluorescence inNicotiana tabacum plant cell culture and the analysis of fluorescence signal was done to be correlated with the viable cell weight. The structured
kinetic model for cell growth was proposed to estimate the theoretical viable cell weight. The dimensional analysis was proposed
for the interpretation of fluorescence signal, in which the path length, the inner filter effect and the hydrodynamic conditions
were considered as the key factors on fluorescence signal. The dimensional analysis and empirical correlation of fluorescence
signal to viable cell weight was applied to the interpretation of the detected fluorescence signal during cultivation. The
proposed interpretation of fluorescence signal using dimensional analysis was well correlated with the viable cell weight
estimated by the structured kinetic model as well as by empirical correlation. 相似文献
5.
6.
Young-Hwan You Won-Gi Jeon Jong-Ho Paik Dae-Ki Hong Hyoung-Kyu Song 《Broadcasting, IEEE Transactions on》2003,49(4):354-361
In this paper, an OFDM-CDMA system employing various diversity schemes is considered for a possible candidate of broadband wireless access networks and broadcasting applications. With an emphasis on a preamble design for multi-channel separation, we address a channel estimation based on the time-domain windowing and its imperfectness in OFDM-based multiple-antenna transmission systems. By properly designing each preamble for multiple antennas to be orthogonal in the time domain, the channel estimation can be applied to the HIPERLAN/2 and IEEE 802.11a standards in the case of more than two transmit antennas. Also, the effect of diversity techniques on the performance of OFDM-CDMA based broadband wireless access networks is investigated and the maximum achievable diversity gain for a two-path Rayleigh fading environment is evaluated. Simulation results show that the OFDM-CDMA system applying a space-time-frequency diversity with a full-rate full diversity code can give the diversity of D=4 and D=8 for both multi-user cases of maximum user and half user capacities, respectively. 相似文献
7.
The cure reactions of epoxy-diamine and its composites are monitored in-situ using the intrinsic fluorescence of the aromatic diamine, diaminodiphenyl sulfone (DDS). With a fiberoptic fluorimeter, in-situ cure monitoring was performed via a single fiber, distal-end probe, in neat epoxy as well as in commercial grade prepregs containing graphite fibers and DDS curing agent. The prepregs were investigated during multiply lamination in an oven. The fluorescence excitation spectra were obtained by emitting at 420 nm with a scan range of 320 to 400 nm, and the DDS peak position was determined as a function of cure time and temperature. The DDS spectra show a progressive red shift up to 24 nm when the primary amine is reacted with epoxide to become the secondary and the tertiary amines. The spectral shift of the DDS is also correlated with the extent of epoxide reaction determined by the Fourier transform infrared (FTIR) spectroscopy. Both data exhibit a linear relation, consistent with the behavior of the DDS peak shift, which increases linearly with the amine reaction. The excitation spectra also show a temperature dependency such that the amount of red shift increases with the measurement temperature in a manner that can be described by an exponential function. The temperature effects also depend on the state of cure in the sample. The temperature correction can be made by the application of an empirically developed equation. Thus, a direct comparison can be made among the on-line data obtained under varying conditions of cure, by reducing the spectral data to any reference temperature. This intrinsic fluorescence technique is much simpler than the previously reported extrinsic fluorophore technique, which requires the addition of an extrinsic fluorophore and an internal dye, and can be applied to any commercial prepregs containing DDS, thus making it a very powerful and widely applicable monitoring tool for composite processing. 相似文献
8.
Pipe piles can be classified as either closed- or open-ended piles. In the present paper, the load capacity of both closed- and open-ended piles is related to cone penetration resistance qc through an experimental program using calibration chamber model pile load tests and field pile load tests. A total of 36 calibration chamber pile load tests and two full-scale field pile load tests were analyzed. All the test piles were instrumented for separate measurement of each component of pile load capacity. Based on the test results, the normalized base resistance qb/qc was obtained as a function of the relative density DR for closed-ended piles, and of both the relative density DR and the incremental filling ratio (IFR) for open-ended piles. A relationship between the IFR and the relative density DR is proposed as a function of the pile diameter and driving depth. The relationship between IFR and DR allows the estimation of IFR and thus of the pile load capacity of open-ended piles at the design stage, before pile driving operations. 相似文献
9.
J.-M. Yoon M.-H. Cho J.-E. Park Y.-H. Kim T.-R. Hahn Y.-S. Paik 《Journal of food science》2003,68(3):839-843
ABSTRACT Three major yellow pigments were isolated from safflower petals ( Carthamus tinctorius ) and characterized as hydroxysafflor yellow A (1), safflor yellow B (2), and precarthamin (3) by 1 H-NMR, 1 H-1 H COSY, 13 C-NMR, HMQC, and HMBC spectral analysis. Thermal degradation reactions of 3 yellow pigments 1 to 3 at temperatures of 70 to 90 °C were carried out at different pH levels within the range of 3.0 to 10.0 by UV-vis spectral measurements. First-order reaction kinetics was observed for the degradation of safflower yellow pigments (1 to 3) at pH 3.0 and 5.0. Activation energies of thermal degradation of 1-3 at pH 5.0 were calculated as 17.0, 15.4, and 20.1 kcal/mol, respectively. At neutral and alkaline conditions, yellow pigments 1-3 did not follow simple first-order kinetics. 相似文献
10.
The high molecular weight (MW) polypropylene with average particle size of 60 nm was synthesized by controlled growth mechanism using Ziegler–Natta catalyst. The atomic force microscopy (AFM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) studies showed that PP nanoparticles were spherical in shape. Structure and crystallinity were concomitantly studied through Fourier transform infrared spectroscopy and X‐ray diffraction, respectively. It shows nanospherical PP particles with more crystallinity (~ 75%) compared with macrosized PP (~ 59%). In addition, differential scanning calorimetry studies revealed the finite particle size effect on Tg and the scale dependence Tg followed a first order exponential trend. As particle size goes down to nano‐ scale from macrosize, continuous elevation of Tg's were observed from ?25 to ?11°C. This phenomenon was directed to configuration entropy of single spherical nanoparticles of PP. The mechanical properties and surface roughness were also evaluated through AFM. At last, the properties of nanosized PP were compared with micron and macrosized particles. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007 相似文献