A versatile wavelet domain noise filtration technique for medical imaging

In this paper, we propose a robust wavelet domain method for noise filtering in medical images. The proposed method adapts itself to various types of image noise as well as to the preference of the medical expert; a single parameter can be used to balance the preservation of (expert-dependent) relevant details against the degree of noise reduction. The algorithm exploits generally valid knowledge about the correlation of significant image features across the resolution scales to perform a preliminary coefficient classification. This preliminary coefficient classification is used to empirically estimate the statistical distributions of the coefficients that represent useful image features on the one hand and mainly noise on the other. The adaptation to the spatial context in the image is achieved by using a wavelet domain indicator of the local spatial activity. The proposed method is of low complexity, both in its implementation and execution time. The results demonstrate its usefulness for noise suppression in medical ultrasound and magnetic resonance imaging. In these applications, the proposed method clearly outperforms single-resolution spatially adaptive algorithms, in terms of quantitative performance measures as well as in terms of visual quality of the images.     

On Stress Intensity Factors of Multiple Cracks at Small Distances in 2-D Problems

In the present work a method is proposed to predict stress intensity factors (SIFs) of strongly interacting cracks at spacings that are substantially smaller than crack lengths. The method is intended for applications where cracks are observed in stack-like/staggered arrangements as in damage patterns of some natural materials with dense lamellar microstructures. The new calculation procedure is inspired by the analytical method of Kachanov (1987) that due to its simplicity has shown to be a powerful tool for analysis of crack interactions. Although in 3-D the accuracy of Kachanov’s method remains good at quite close spacings, in 2-D problems it, however, quickly drops as the distance between cracks decreases, underestimating the effect of crack interactions, especially in ordered staggered arrangements. In this work we introduce new modeling assumptions that are suited for problems where stress fields have high gradients – a typical situation in the case of closely spaced parallel cracks. The accuracy of the method is examined on the example of two stacked cracks. The use of SIFs for estimation of material elastic compliance is also discussed.     

Automatic initial estimation of the left ventricular myocardialmidwall in emission tomograms using Kohonen maps

A new method to make an automatic initial estimation of the position of the middle of the left ventricular (LV) myocardial wall (LV myocardial midwall) in emission tomograms is presented. This method eliminates the manual interaction still required by other, more accurate LV delineation algorithms, and which consists of indicating the LV long axis and/or the LV extremities. A well-known algorithm from the world of neural networks, Kohonen's self-organizing maps, was adapted to use general shapes and to behave well for data with large background noise     

Management and enterprise architecture click: The FAD(E)E framework

Enterprises are living things. They constantly need to be (re-)architected in order to achieve the necessary agility, alignment and integration. This paper gives a high-level overview of how companies can go about doing ‘enterprise architecture’ in the context of both the classic (isolated) enterprise and the Extended Enterprise. By discussing the goals that are pursued in an enterprise architecture effort we reveal some basic requirements that can be put on the process of architecting the enterprise. The relationship between managing and architecting the enterprise is discussed and clarified in the FAD(E)E, the Framework for the Architectural Development of the (Extended) Enterprise. Frank G. Goethals completed his Master studies in economics (option informatics), at the Katholieke Universiteit Leuven, Belgium, in 2000. He is presently researching for a Ph.D. under the theme of `Managing data in the Extended Enterprise'. This research is conducted at the K.U.Leuven under the guidance of professor J. Vandenbulcke, and is financed by SAP Belgium. Frank has a strong interest in coordination and dependency theory and Enterprise Architecture. Monique Snoeck obtained her Ph.D. in May 1995 from The Department of Computer Science of the Katholieke Universiteit Leuven with a thesis that lays the formal foundations of the object-oriented business modelling method MERODE. Since then she has done further research in the area of formal methods for object-oriented conceptual modelling. She now is Full Professor with the Management Information Systems Group of the Faculty of Economics and Applied Economics at the Katholieke Universiteit Leuven in Belgium. She has been involved in several industrial conceptual modelling projects. Her research interests are object oriented conceptual modelling, software architecture and software quality. Wilfried Lemahieu holds a Ph.D. from the Department of Applied Economic Sciences of the Katholieke Universiteit Leuven, Belgium (1999). At present, he is associate professor at the Management Informatics research group of the Faculty of Economics and Applied Economics. His teaching includes Database Management, Data Storage Architectures and Management Informatics. His research interests comprise distributed object architectures and web services, object-relational and object-oriented database systems and hypermedia systems. Jacques A. Vandenbulcke is professor at the Faculty of Economics and Applied Economics of the Katholieke Universiteit Leuven, Belgium. His main research interests are in Database management, Data modelling, and Business Information Systems. He is co-ordinator of the Leuven Institute for Research on Information Systems (LIRIS) and holder of the SAP-chair on ‘Extended enterprise infrastructures’. He is president of ‘Studiecentrum voor Automatische Informatieverwerking (SAI)’, the largest society for computer professionals in Belgium, and co-founder of the ‘Production and Inventory Control Society (PICS)’ in Belgium.     

Homogenization of metamaterials using full-wave simulations

We present a full-wave homogenization method to determine the effective material parameters of metamaterials by considering a spherical piece of metamaterial. We use a T-matrix approach that is accelerated by a multilevel fast multipole method that is stable at low frequencies. To determine the T-matrix of one inclusion in the metamaterial a Method of Moments surface integral equation is used that is also accelerated using another multilevel fast multipole method that is stable at low frequencies. We also derive a new closed-form expression to extract the effective material parameters from the T-matrix of the spherical piece of material. Examples verify the accuracy and limitations of the method. We show results for metamaterials comprising more than 40,000 particles.     

Automatic Detection of Spike and Wave Discharges in the EEG of Genetic Absence Epilepsy Rats From Strasbourg

Genetic absence epilepsy rats from Strasbourg are a strain of Wistar rats in which all animals exhibit spontaneous occurrences of spike and wave discharges (SWDs) in the EEG. In this paper, we propose a novel method for the detection of SWDs, based on the key observation that SWDs are quasi-periodic signals. The method consists of the following steps: 1) calculation of the spectrogram; 2) estimation of the background spectrum and detection of stimulation artifacts; 3) harmonic analysis with continuity analysis to estimate the fundamental frequency; and 4) classification based on the percentage of power in the harmonics to the total power of the spectrum. We evaluated the performance of the novel detection method and six SWD/seizure detection methods from literature on a large database of labeled EEG data consisting of two datasets running to a total duration of more than 26 days of recording. The method outperforms all tested SWD/seizure detection methods, showing a sensitivity and selectivity of 96% and 97%, respectively, on the first test set, and a sensitivity and selectivity of 94% and 92%, respectively, on the second test set. The detection performance is less satisfactory (as for all other methods) for EEG fragments showing more irregular and less periodic SWDs.     

Stability effects associated with the introduction of a partial and a complete Ca2+-binding site into human lysozyme

Two mutants of human lysozyme were synthesized. Mutant A92D,in which Ala92 was substituted by Asp, contains a partial Ca²⁺-bindingsite and mutant M4, in which Ala83, Gm86, Asn88 and Ala92 werereplaced by Lys, Asp, Asp and Asp respectively, contains thecomplete Ca -binding site of bovine a-lactalbumin. The Ca²⁺-bindingconstants of wild type human lysozyme and of mutants A92D andM4, measured at 25C and pH 7.5, were 2(1) x 102 M"1, 8(2)x l^M"1 and 9(0.5) x 10* M"1 respectively. Information gatheredfrom mkrocalorimetrk and CD spectro-scopic measurements indicatesthat the conformational changes of the M4 mutant lysozyme, inducedby Ca²⁺ binding, are smaller than those observed for bovinea-lactalbumin and for the Ca²⁺-binding equine lysozyme. At pH4.5, the thermostability of both the apo and Ca²⁺ forms of theA92D human was decreased in comparison with that of native humanlysozyme. In particular, within the apo form of this mutantan a-helix-containing sequence was destabilized. In contrast,at the same pH the thermostability of the apo and Ca²⁺ formsof the M4 mutant lysozyme was increased. The e-ammonium groupof the Lys83 side chain is assumed to be responsible for thestabilization of the apo form of this mutant.     

Modelling the polypeptide backbone with 'spare parts' from known protein structures

An automatic procedure for building a protein polyalanine backbonefrom C positions and ‘spare parts’ retrieved froma data base of 66 high-resolution protein structures is described.Protein backbones are constructed from over-lapping fragmentsof variable length, which allows the backbone of regular secondarystructure elements to be built in one block. The procedure isshown to yield backbones which compare very favourably withthose from highly refined X-ray structures (r.m.s. deviationbetween generated and crystal structures <lÅ). Themethod is furthermore quite insensitive to experimental errorsin C positions as well as to the size of the data base, andis seen to yield valuable insight into the relationships betweensequence and 3-D structure: one example on triose phosphateisomerase, a ß-barrel protein, shows that ßloops can be considered as structurally more uncommon than ßloops. The ‘spare parts’ approach is also foundto be useful for general-purpose modelling of local structuralchanges produced by insertion or deletion of residues. It should,however, be used with caution. Crude selection criteria basedsolely on fragment length and geometric fit to the loop baseregions yield realistic backbones in about two-thirds of thetest cases (r.m.s. deviations from refined crystal structure{small tilde}lÅ). In the remaining cases, sequence information,in particular the presence of glycine residues which tend toadopt more unusual backbone conformations, must be consideredto obtain comparable results.     

Extrusion of Nanocellulose‐Reinforced Nanocomposites Using the Dispersed Nano‐Objects Protective Encapsulation (DOPE) Process

Cross‐linked alginate capsules a few millimeters in diameter have been formed by immersion in a CaCl₂ solution. When adding cellulose whiskers or microfibrillated cellulose to the aqueous alginate solution, nanocomposite capsules containing 40 wt.% cellulosic nanoparticles were obtained. The morphology and compression strength of these capsules were investigated by microscopic observations and crushing tests, respectively. The capsules were extruded with a thermoplastic polymer. Visual inspection of the ensuing films shows a nonhomogeneous dispersion of the capsules that kept their integrity after extrusion. It results in preliminary disappointing mechanical properties of the composite films. However, further investigation is in progress to optimize this simple and ecofriendly process.