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1.
Kirk Weller Ilana Arnon Ed Dubinsky 《Canadian Journal of Science, Mathematics, & Technology Education》2013,13(2):129-159
Abstract In an earlier study of preservice elementary and middle school teachers’ beliefs about repeating decimals, Weller, Arnon, and Dubinsky (2009) reported on a comparison of the mathematical performance of 77 preservice teachers who completed an APOS-based instructional unit with 127 preservice teachers who completed traditional instruction. The purpose of the current study, based on 47 interviews conducted 4 months after the instruction, during which time there was no further instruction on this topic, is to determine the strength and stability (over time) of the students’ beliefs, to uncover thinking that did not arise in the earlier study, and to see whether the interviews yield similar comparative results. The interviews did uncover changes in student thinking. The students who received the APOS-based instruction developed stronger and more stable (over time) beliefs that a repeating decimal is a number; a repeating decimal has a fraction or integer to which it corresponds; a repeating decimal in general equals its corresponding fraction or integer; and, in particular, In addition, a number of indices and categories were developed that may prove useful in other studies consisting of the comparison of interview and questionnaire data involving a large number of interview subjects. 相似文献
2.
Vishnu Priya Sampath Shiv Vardan Singh Ilana Pelov Ofir Tirosh Yigal Erel David Lichtstein 《International journal of molecular sciences》2022,23(22)
Bipolar Disorder (BD) is a severe recurrent affective mood disorder characterized by a wide range of lifelong mood swings, varying between depressive and manic states. BD affects more than 1% of the world’s population irrespective of nationality, ethnic origin, or socioeconomic status and is one of the main causes of disability among young people, leading to cognitive and functional impairment and raised mortality, particularly death by suicide. Trace elements play a vital role in many biochemical and physiological processes. Compelling evidence shows that element toxicity might play a crucial role in the onset and progression of neurodegenerative disorders, but their involvement in mood disorders has been scarcely studied. In the present investigation, we determined the concentration of 26 elements in the serum of BD patients before and after treatment and in postmortem brain samples from BD patients and compared them with matched controls. The only element that was reduced significantly in the serum following treatment was vanadium (V). Furthermore, the concentration of Al, B, Cu, K, Mg and V were significantly lower in the pre-frontal cortex of BD patients compared with those of the controls. A comparison of Spearman’s rank correlation coefficients between the elements in the serum and brain of BD patients and control groups pointed to boron and aluminum as being involved in the disease. These results suggest that there is a disturbance in the elements’ homeostasis and the inter-elements’ relationship in the brain of BD patients and advocate a thorough examination of the possible involvement of chemical elements in different stages of the disease. 相似文献
3.
Inspection of the amino acid-base interactions in protein-DNA complexes is essential to the understanding of specific recognition of DNA target sites by regulatory proteins. The accumulation of information on protein-DNA co-crystals challenges the derivation of quantitative parameters for amino acid-base interaction based on these data. Here we use the coordinates of 53 solved protein-DNA complexes to extract all non-homologous pairs of amino acid-base that are in close contact, including hydrogen bonds and hydrophobic interactions. By comparing the frequency distribution of the different pairs to a theoretical distribution and calculating the log odds, a quantitative measure that expresses the likelihood of interaction for each pair of amino acid-base could be extracted. A score that reflects the compatibility between a protein and its DNA target can be calculated by summing up the individual measures of the pairs of amino acid-base involved in the complex, assuming additivity in their contributions to binding. This score enables ranking of different DNA binding sites given a protein binding site and vice versa and can be used in molecular design protocols. We demonstrate its validity by comparing the predictions using this score with experimental binding results of sequence variants of zif268 zinc fingers and their DNA binding sites. 相似文献
4.
Tunneling in the forward bias polarity of a field induced diode in indium antimonide is treated theoretically and experimentally. The theory leads to tunneling current-voltage characteristics with a region of negative resistance which are dependent upon the various parameters of the device, such as the gate voltage, substrate acceptor concentration and oxide thickness. A three-terminal device in which the gate voltage controls the tunneling I–V characteristics can thus be realized.Measurements were performed on an experimental device obtained by diffusion of cadmium into N-type InSb semiconductor. A chemically deposited SiO2 layer was used to isolate the evaporated CrAu gate electrode from the substrate. Deviations from theory are shown to result from the two-dimensional character of the device. 相似文献
5.
We investigated possible explanations of the finding that the relative weight (W) of common components in similarity judgments is higher for verbal than for pictorial stimuli. A serial presentation of stimulus components had no effect on verbal stimuli; it increased the impact of both common and distinctive components of pictorial stimuli but did not affect their relative weight. On the other hand, W was increased by manipulations that reduced the cohesiveness of composite pictures, such as separating, scrambling, and mixing their components. Furthermore, W was decreased by manipulations that enhanced the cohesiveness of composite verbal stimuli by imposing structure on their components. Verbal and pictorial representations of the same stimuli yielded no systematic differences in W. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Kuhn J Suissa M Chiswell D Azriel A Berman B Shahar D Reznick S Sharf R Wyse J Bar-On T Cohen I Giles R Weiser I Lubinsky-Mink S Ulitzur S 《International journal of food microbiology》2002,74(3):217-227
Felix 01 (F01) is a bacteriophage originally isolated by Felix and Callow which lyses almost all Salmonella strains and has been widely used as a diagnostic test for this genus. Molecular information about this phage is entirely lacking. In the present study, the DNA of the phage was found to be a double-stranded linear molecule of about 80 kb. 11.5 kb has been sequenced and in this region A + T content is 60%. There are relatively few restriction endonuclease cleavage sites in the native genome and clones show this is due to their absence rather than modification. A restriction map of the genome has been constructed. The ends of the molecule cannot be ligated although they contain 5' phosphates. At least 60% of the genome must encode proteins. In the sequenced portion, many open reading frames exist and these are tightly packed together. These have been examined for homology to published proteins but only 1 to 17 shows similarity to known proteins. F01 is therefore the prototype of a new phage family. On the basis of restriction sites, codon usage and the distribution of nonsense codons in the unused reading frames, a strong case can be made for natural selection that reacts to mRNA structure and function. 相似文献
7.
Hui-Chung Wu Ricky Nguyen Mindy Goldsborough Ilana Margalit Cindy Breed Arezou Azarani 《Journal of The Association for Laboratory Automation》2003,8(1):28-30
Automating electrophoresis significantly reduces the time required for loading a large number of samples, increases the speed of electrophoresis analysis, and maximizes the resolution power (clear separation of fragments) of this technique. In addition, automation increases the precision of electrophoresis analysis. Here we demonstrate an automated, high-throughput method of loading 96 samples simultaneously onto an electrophoresis gel, using the Apogent Discoveries Tango™ system and the Invitrogen™ E-Gel® 96 system. 相似文献
8.
Self-checking circuits detect (at least some of) their own faults. We describe self-timed circuits, including combinational logic and sequential machines, which either halt or generate illegal output if they include any single stuck-at faults. The self-timed circuits employ dual rail data encoding to implement ternary logic of 0, 1, andundefined states; the fourth state is used to signal illegal output and is shown to result only from certain circuit faults. The self-timed circuits also employ four-phase signaling according to a well-defined protocol of communications between the circuit and its environment; failures due to certain faults prevent the circuit from communicating properly, thus causing the circuit to halt. We show that any single stuck-at fault falls in either the first or the second category, thus providing complete fault coverage through self checking. No hardware needs to be added to our circuits to achieve the complete self-checking property; further, the circuit is guaranteed to never generate a legal but erroneous output if it contains a fault. Minimal hardware is needed to detect that a circuit has either halted or has generated an illegal output. 相似文献
9.
Zohar Bloom-Ackermann Hadas Ganin Ilana Kolodkin-Gal 《Israel journal of chemistry》2016,56(5):302-309
Quorum sensing (QS) is an efficient mode of intercellular communication between bacteria. This mode is regulated by self-produced small chemical signals, activating dedicated receptors once accumulated. Numerous architecturally complex QS cascades are cardinal for governing bacterial behaviors, such as pathogenicity, luminescence, and bacterial competence. Importantly, QS cascades are essential for the formation of bacterial multicellular communities. Once informed via QS cascades, motile cells often organize themselves into conspicuous multicellular structures that carry out specialized tasks. This review focuses on the major QS systems, playing an active role in the rise of complex bacterial communities in different bacterial models. 相似文献
10.