High density recording with perpendicular Co-Cr-Nb media and ring heads

Effective double layer structure was investigated by adding Nb to the sputtering source of Co-Cr thin film perpendicular magnetic recording tapes. The output from the tapes was measured with a ring head through to the short wavelength, λ50=0.19 μm (D50=267KFRPI).     

Effects of Particle Size of Bulk Drug and food on the Bioavailability of U-78875 in Dogs

The effects of particle size and food on the absolute bioavailability of U-78875 in dogs after oral administration of either a suspension or tablet dosage form were investigated. A reduction of particle size caused a significant increase in bioavailability along with an increase in dissolution rate. Additionally, both suspension and tablet dosage forms administered after food caused an increase in bioavailability. Thus, to accelerate drug dissolution, a reduction of U-78875 particle size from the unmilled state is important for the optimization of formulation compositions. To increase the bioavailability of U-78875, postprandial dosing should be considered.     

Static Coarse Grain Task Scheduling with Cache Optimization Using OpenMP

Effective use of cache memory is getting more important with increasing gap between the processor speed and memory access speed. Also, use of multigrain parallelism is getting more important to improve effective performance beyond the limitation of loop iteration level parallelism. Considering these factors, this paper proposes a coarse grain task static scheduling scheme considering cache optimization. The proposed scheme schedules coarse grain tasks to threads so that shared data among coarse grain tasks can be passed via cache after task and data decomposition considering cache size at compile time. It is implemented on OSCAR Fortran multigrain parallelizing compiler and evaluated on Sun Ultra80 four-processor SMP workstation using Swim and Tomcatv from the SPEC fp 95. As the results, the proposed scheme gives us 4.56 times speedup for Swim and 2.37 times on 4 processors for Tomcatv respectively against the Sun Forte HPC Ver. 6 update 1 loop parallelizing compiler.     

Review of the main developments in the analytic hierarchy process

In this paper the authors review the developments of the analytic hierarchy process (AHP) since its inception. The focus of this paper is a neutral review on the methodological developments rather than reporting its applications that have appeared since its introduction. In particular, we discuss problem modelling, pair-wise comparisons, judgement scales, derivation methods, consistency indices, incomplete matrix, synthesis of the weights, sensitivity analysis and group decisions. All have been important areas of research in AHP.     

Loading sequence plays an important role in enhanced load sensitivity of left ventricular relaxation in conscious dogs with tachycardia-induced cardiomyopathy

BACKGROUND: Left ventricular relaxation rate in the failing heart depends more on the systolic load than in the normal heart. To elucidate the mechanisms for the enhanced load sensitivity of left ventricular relaxation in heart failure, we examined the relative contributions of changes in end-systolic volume and loading sequence to the left ventricular relaxation rate. METHODS AND RESULTS: In seven conscious dogs, the time constant (Td) of left ventricular pressure decay, end-systolic volume, systolic circumferential force, and time to peak force during caval occlusion were compared before and after development of tachycardia-induced heart failure. Rapid ventricular pacing decreased the slope of the end-systolic pressure-volume relation from 4.5 to 2.8 mm Hg/mL (P < .01) and prolonged Td from 33 to 49 ms (P < .01). In normal conditions, caval occlusion reduced end-systolic force (-580 g, P < .01) and end-systolic volume (-7 mL, P < .01) but did not change Td or time to peak force. In heart failure, however, caval occlusion shortened Td (-11 ms, P < .01), with a concomitant decrease in the time to peak force (-30 ms, P < .01), while end-systolic volume and force declined slightly. Consequently, for a comparable reduction in end-systolic force, Td decreased more in heart failure than in normal hearts, suggesting enhanced load sensitivity. Moreover, changes in Td correlated well with those in the time to peak force (r = .79, P < .01) but not with those in end-systolic volume. CONCLUSIONS: Loading sequence rather than elastic recoil seems to play the predominant role in the enhanced load sensitivity of left ventricular relaxation in heart failure.     

Wavelength-independent operation of EA-modulator integratedwavelengthselectable microarray light sources

In this letter, we have simultaneously fabricated five wavelength-selectable microarray light sources (WSLs), each having a different wavelength range integrated with an electroabsorption (EA) modulator on a single wafer. We also introduced a novel device configuration scheme for wavelength-independent modulation. The five EA-WSLs fully covered the entire C-band and had a low uniform threshold current of 6 ± 1 mA at 25°C. Wavelength-independent extinction characteristics were obtained over a tuning wavelength range of 8 nm, and 2.5-Gb/s transmission over 600 km was successfully achieved     

Retroviral transfer of CPP32beta gene into malignant gliomas in vitro and in vivo

Malignant gliomas are highly aggressive neoplasms that are very resistant to current therapeutic approaches, including irradiation, chemotherapy, and immunotherapy. To improve the prognosis, it is absolutely essential to explore novel modalities of treatment. Recently, we have demonstrated that interleukin 1beta-converting enzyme (ICE), a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3, induces apoptotic cell death in malignant glioma cells. To date, ICE and ICE-like proteases (the ICE family), such as Ich-1L, CPP32beta, Mch2alpha, and Mch3alpha, have been shown to mediate apoptosis in some cells. The purpose of this study is to determine whether the ICE gene family functions as a useful tool for the treatment of malignant glioma cells through induction of apoptosis. The transient transfection assays showed that CPP32beta and Mch2alpha genes induced apoptotic cell death in malignant glioma cells more effectively than did the ICE, Ich-1L, and Mch3alpha genes. To improve the efficiency of gene transfer into malignant glioma cells, we constructed the retroviral vectors containing the ICE gene family. The retroviral transfer of CPP32beta or Mch2alpha gene effectively induced apoptosis in malignant glioma cells in vitro. Furthermore, treatment of tumors grown in mice with retrovirus containing CPP32beta significantly inhibited growth of the tumors through induction of apoptosis. The retroviral transfer of CPP32beta or Mch2alpha, therefore, may be a novel and promising approach for the treatment of malignant glioma, an invariably fatal tumor.     

Partial renal embolization for pediatric renovascular hypertension secondary to fibromuscular dysplasia

We report a 7-year-old boy with renovascular hypertension showing multiple stenoses and microaneurysms of the dorsal branch of the left renal artery caused by fibromuscular dysplasia. Hypertension was successfully treated with transcatheter alcohol and gelatin sponge embolization of the dorsal branch and its distribution. The vertebral branch remained intact. No severe complication was encountered. Loss of renal function by renal scintigraphy was minimal. The patient remains asymptomatic at 1 year.     

Modulator integrated DFB lasers with more than 600-km transmission capability at 2.5 Gb/s

The modulator integrated DFB laser diodes with more than 600-km transmission capability over normal fiber at 2.5 Gb/s, have been reproducibly achieved. The longest transmission length obtained in the experiment is as long as 800 km.