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The aim of this work is to develop an Internet and fuzzy based control and data acquisition system for an industrial process plant which can ensure remote running and fuzzy control of a cement factory. Cases studies of the proposed system application in three cement factories in Algeria, SCAEK (Setif), SCIMAT (Batna), and SCT (Tebessa), are discussed. The remote process control consists of alarms generated during running of the processes while maintaining and synchronizing different regulation loops thus ensuring automatic running of processes smoothly. In addition, fuzzy control of the kiln and the other two mills ensures that the system is operational at all times with minimal downtime. The process control system contains different operator station (OP), alarms table and a provision to monitor trends analysis. The operator can execute any operation according to his authorised access assigned by the system administrator using user administration tool. The Internet technology is used for human security by avoiding all times presence of operators at site for maintenance. Further, in case of a breakdown, the problem would be remotely diagnosed and resolved avoiding requirement of an expert on site thus eliminating traveling cost, security risks, visa formalities, etc. These trips are difficult to organize (costs, visas, risks). So the enterprise can reduce downtimes and travel costs. In order to realize a process control system guided by operators in the main control room or through Internet, the process control is based on programming in PCS 7 utilizing Cemat library and Fuzzy Control++ Siemens tools. 相似文献
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Novel Tacrine‐Grafted Ugi Adducts as Multipotent Anti‐Alzheimer Drugs: A Synthetic Renewal in Tacrine–Ferulic Acid Hybrids
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Mohamed Benchekroun Dr. Manuela Bartolini Dr. Javier Egea Dr. Alejandro Romero Dr. Elena Soriano Dr. Marc Pudlo Vincent Luzet Prof. Vincenza Andrisano Dr. María‐Luisa Jimeno Dr. Manuela G. López Sarah Wehle Prof. Tijani Gharbi Prof. Bernard Refouvelet Lucía de Andrés Clara Herrera‐Arozamena Prof. Barbara Monti Prof. Maria Laura Bolognesi Prof. María Isabel Rodríguez‐Franco Prof. Dr. Michael Decker Prof. José Marco‐Contelles Dr. Lhassane Ismaili 《ChemMedChem》2015,10(3):523-539
Herein we describe the design, multicomponent synthesis, and biological, molecular modeling and ADMET studies, as well as in vitro PAMPA‐blood–brain barrier (BBB) analysis of new tacrine–ferulic acid hybrids (TFAHs). We identified (E)‐3‐(hydroxy‐3‐methoxyphenyl)‐N‐{8[(7‐methoxy‐1,2,3,4‐tetrahydroacridin‐9‐yl)amino]octyl}‐N‐[2‐(naphthalen‐2‐ylamino)2‐oxoethyl]acrylamide (TFAH 10 n ) as a particularly interesting multipotent compound that shows moderate and completely selective inhibition of human butyrylcholinesterase (IC50=68.2 nM ), strong antioxidant activity (4.29 equiv trolox in an oxygen radical absorbance capacity (ORAC) assay), and good β‐amyloid (Aβ) anti‐aggregation properties (65.6 % at 1:1 ratio); moreover, it is able to permeate central nervous system (CNS) tissues, as determined by PAMPA‐BBB assay. Notably, even when tested at very high concentrations, TFAH 10 n easily surpasses the other TFAHs in hepatotoxicity profiling (59.4 % cell viability at 1000 μM ), affording good neuroprotection against toxic insults such as Aβ1–40, Aβ1–42, H2O2, and oligomycin A/rotenone on SH‐SY5Y cells, at 1 μM . The results reported herein support the development of new multipotent TFAH derivatives as potential drugs for the treatment of Alzheimer′s disease. 相似文献
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Microwave irradiation under different pH conditions induced a decrease in β-lactoglobulin antigenicity 总被引:1,自引:0,他引:1
Hadria Grar Hanane Kaddouri Hanane Gourine Hanane Negaoui Omar Kheroua Djamel Saïdi 《European Food Research and Technology》2009,229(5):779-783
Whey proteins adjusted at pH values 2, 4.6, 9 and at the natural milk pH (pH 6.8) were subjected to microwave irradiation
at 300 W for 20 min or 700 W for 10 min. The protein composition of treated and native whey proteins were evaluated by Lowry’s
method and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The ability of treated whey to bind IgG polyclonal
antibody was determined by an enzyme-linked immunosorbent assay (ELISA) using sera obtained from rabbit immunized to β-Lactoglobulin
(β-Lg). Significantly higher losses in soluble protein concentrations were observed for microwave irradiated whey proteins
at pH value 4.6 (35.6% at 300 W and 44.33% at 700 W) (P < 0.0001) compared with those irradiated at the natural milk pH (26% at 300 or 700 W). The electrophoretic patterns of these
proteins revealed a considerable decrease in intensity of the band corresponding to α-lactalbumin but only a slight modification
was observed for the electrophoretic profiles of β-lactoglobulin. The data obtained with a rabbit anti-β-lactoglobulin immunoglobulin
indicated a low antigenic response for microwave-irradiated whey proteins at the natural milk pH (up to 29.32% as well as
300–700 W) (P < 0.001). The lowest antigenicity was observed for samples adjusted to pH 4.6 followed by microwave irradiation at 300 or
700 W (46.99% at 300 W and 41.16% at 700 W) (P < 0.0001). 相似文献
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Hanane Fathi SeongHan Shin Kazukuni Kobara Hideki Imai 《Wireless Personal Communications》2010,54(1):225-236
To avoid the risk of long-term storage of secrets on a portable device, an online credential system supports the roaming user
in retrieving securely at various locations his private key and other material to generate anonymous signatures. The protocol
proposed here allows a roaming mobile user to access anonymously services such as whistle blowing and net-counselling. Our
approach: (1) allows a mobile user, remembering a short password, to anonymously and securely retrieve the credentials necessary
for his anonymous communication without assuming a pre-established anonymous channel to the credential server or establishing
an anonymous channel using the time-consuming existing rerouting techniques; (2) provides authenticated anonymous access to
privacy-related services without rerouting the packets; (3) helps combatting the abuse of anonymity for performing illegal
activities (e.g. redistribution of copy-righted contents, illegal drug trading and so on). 相似文献
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Hanane Laouira Fateh Mebarek‐Oudina Ahmed K. Hussein Lioua Kolsi Amine Merah Obai Younis 《亚洲传热研究》2020,49(1):406-423
The heat transfer phenomena inside a horizontal channel with an open trapezoidal enclosure subjected to a heat source of different lengths was investigated numerically in the present work. The heat source is considered as a local heating element of varying length, which is embedded at the bottom wall of the enclosure and maintained at a constant temperature. The air flow enters the channel horizontally at a constant cold temperature and a fixed velocity. The other walls of the enclosure and the channel are kept thermally insulated. The flow is assumed laminar, incompressible, and two‐dimensional, whereas the fluid is considered Newtonian. The results are presented in the form of the contours of velocity, isotherms, and Nusselt numbers profiles for various values of the dimensionless heat source lengths (0.16 ≤ ε ≤ 1). while, both Prandtl and Reynolds numbers are kept constant at (Pr = 0.71) and (Re = 100), respectively. The results indicated that the distribution of the isotherms depends significantly on the length of the heat source. Also, it was noted that both the local and the average Nusselt numbers increase as the local heat source length increases. Moreover, the maximum temperature is located near the heat source location. 相似文献
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Dr. Lukas Greifenstein Dr. Nils Engelbogen Hanane Lahnif Dr. Jean-Philippe Sinnes Prof. Dr. Ralf Bergmann Prof. Dr. Michael Bachmann Prof. Dr. Frank Rösch 《ChemMedChem》2020,15(8):695-704
The L-lysine urea-L-glutamate (KuE) represents a key motif in recent diagnostic and therapeutic radiopharmaceuticals targeting the prostate specific membrane antigen (PSMA). Using a squaric acid moiety for coupling of KuE with a radioactive label, the squaric acid as a linker in the PSMA ligand seems to mimic the aromatic structure of the naphthylalanine unit on PSMA-617. In this work, we investigate the influence of squaric acid moiety on the biological activity of the compound carrying a KuE motif and three typical chelates. The derivatives TRAM.SA.KuE, DOTAGA.SA.KuE and NODAGA.SA.KuE were all synthesized in straightforward organic reactions and purified by HPLC afterward. Different amounts of tracer were labeled at different temperatures with 68Ga. PET examinations were performed on NMRInu/nu nude mice with an LNCaP tumor on the right hind leg including ex vivo investigations of the organs. For comparison, 68Ga-derivatives of PSMA-11 and PSMA-617, the derivatives most commonly used in clinics, were investigated in the same animal model. 相似文献
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The need for motion estimation (ME) arises quite often in many areas such as computer vision, target tracking, medical imaging, robotic vision. A five new estimators for frame-to-frame image ME are described in this paper. The new ME estimators exploit the higher-order statistics (HOS) characteristics of the received images, and various frequency weighting functions are used to prefilter the received images before calculating the generalized cross-cumulant function and, therefore, suppress the Gaussian noise effect. The estimators of interest are the HOS-ROTH impulse response, the HOS-phase transform, the HOS-smoothed coherence transform, the HOS-maximum likelihood and the HOS-Wiener estimators. Since the performances of the HOS-based estimators are considerably degraded by the signal-to-noise ratio level, this factor has been taken as a prime factor in benchmarking the different estimators. For robust ME it has been found that the HOS-Wiener estimator is particularly suited to this purpose. The accuracy of the estimators is also discussed. 相似文献
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E-commerce (business-to-consumer electronic commerce), one form of which is Web-based shopping, is defined as electronic-based economic transactions conducted between individual consumers and organizations. While this form of ecommerce is forecasted to grow rapidly for the foreseeable future, it still represents only a small fraction of total consumer spending. To better take advantage and be prepared for this economic phenomenon, organizations need to identify and understand factors that may impact consumers' decisions to engage in Web-based e-commerce. Recently, the importance of security has been discussed in both the academic and practitioner press. The impact of security on the use of e-commerce has been established empirically. 相似文献