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2.
Martijn H. A. Bonte Lionel Fourment Tien-tho Do A. H. van den Boogaard J. Huétink 《Structural and Multidisciplinary Optimization》2010,42(5):797-810
During the last decades, simulation software based on the Finite Element Method (FEM) has significantly contributed to the
design of feasible forming processes. Coupling FEM to mathematical optimization algorithms offers a promising opportunity
to design optimal metal forming processes rather than just feasible ones. In this paper Sequential Approximate Optimization (SAO) for optimizing forging processes is discussed. The algorithm
incorporates time-consuming nonlinear FEM simulations. Three variants of the SAO algorithm—which differ by their sequential
improvement strategies—have been investigated and compared to other optimization algorithms by application to two forging
processes. The other algorithms taken into account are two iterative algorithms (BFGS and SCPIP) and a Metamodel Assisted
Evolutionary Strategy (MAES). It is essential for sequential approximate optimization algorithms to implement an improvement
strategy that uses as much information obtained during previous iterations as possible. If such a sequential improvement strategy
is used, SAO provides a very efficient algorithm to optimize forging processes using time-consuming FEM simulations. 相似文献
3.
Damien Trentesaux Cyrille Pach Abdelghani Bekrar Yves Sallez Thierry Berger Thérèse Bonte Paulo Leitão José Barbosa 《Control Engineering Practice》2013,21(9):1204-1225
Benchmarking is comparing the output of different systems for a given set of input data in order to improve the system’s performance. Faced with the lack of realistic and operational benchmarks that can be used for testing optimization methods and control systems in flexible systems, this paper proposes a benchmark system based on a real production cell. A three-step method is presented: data preparation, experimentation, and reporting. This benchmark allows the evaluation of static optimization performances using traditional operation research tools and the evaluation of control system's robustness faced with unexpected events. 相似文献
4.
Aquifers used for the production of drinking water are increasingly being used for the generation of shallow geothermal energy. This causes temperature perturbations far beyond the natural variations in aquifers and the effects of these temperature variations on groundwater quality, in particular trace elements, have not been investigated. Here, we report the results of column experiments to assess the impacts of temperature variations (5°C, 11°C, 25°C and 60°C) on groundwater quality in anoxic reactive unconsolidated sandy sediments derived from an aquifer system widely used for drinking water production in the Netherlands. Our results showed that at 5 °C no effects on water quality were observed compared to the reference of 11°C (in situ temperature). At 25°C, As concentrations were significantly increased and at 60 °C, significant increases were observed pH and DOC, P, K, Si, As, Mo, V, B, and F concentrations. These elements should therefore be considered for water quality monitoring programs of shallow geothermal energy projects. No consistent temperature effects were observed on Na, Ca, Mg, Sr, Fe, Mn, Al, Ba, Co, Cu, Ni, Pb, Zn, Eu, Ho, Sb, Sc, Yb, Ga, La, and Th concentrations, all of which were present in the sediment. The temperature-induced chemical effects were probably caused by (incongruent) dissolution of silicate minerals (K and Si), desorption from, and potentially reductive dissolution of, iron oxides (As, B, Mo, V, and possibly P and DOC), and mineralisation of sedimentary organic matter (DOC and P). 相似文献
5.
Greg Mann Dr. Liujie Huo Sebastian Adam Dr. Brunello Nardone Dr. Jeremie Vendome Prof. Nicholas James Westwood Prof. Rolf Müller Dr. Jesko Koehnke 《Chembiochem : a European journal of chemical biology》2016,17(23):2286-2292
The bottromycins are a family of highly modified peptide natural products, which display potent antimicrobial activity against Gram‐positive bacteria, including methicillin‐resistant Staphylococcus aureus. Bottromycins have recently been shown to be ribosomally synthesized and post‐translationally modified peptides (RiPPs). Unique amongst RiPPs, the precursor peptide BotA contains a C‐terminal “follower” sequence, rather than the canonical N‐terminal “leader” sequence. We report herein the structural and biochemical characterization of BotP, a leucyl‐aminopeptidase‐like enzyme from the bottromycin pathway. We demonstrate that BotP is responsible for the removal of the N‐terminal methionine from the precursor peptide. Determining the crystal structures of both apo BotP and BotP in complex with Mn2+ allowed us to model a BotP/substrate complex and to rationalize substrate recognition. Our data represent the first step towards targeted compound modification to unlock the full antibiotic potential of bottro‐ mycin. 相似文献
6.
We present two detailed studies concerning thedmt and the multichannelhemt for power amplifications. Each work comprises a first theoretical part where the structure is optimized by simulating the device. Technological realizations are hence performed at the laboratory. The following measurements give results very encouraging and permit to foresee the superior performance relatively to that of GaAs powermesfet. 相似文献
7.
Joost Van Slycken Patricia Verleysen Joris Degrieck Jeremie Bouquerel Bruno C. De Cooman 《Metals and Materials International》2007,13(2):93-101
Multiphase TRansformation Induced Plasticity (TRIP) steels combine excellent ductility and high strength, making them ideally
suited for shock absorbing parts in the automotive industry. When designing structures for impact, an understanding of the
mechanical properties of materials under high strain rate conditions is essential. An extensive experimental program using
a split Hopkinson tensile bar set-up was established in an effort to investigate the dynamic properties of various TRIP steel
grades. Four different TRIP steels are described with varying contents of the alloying elements silicon, aluminium and phosphor.
Moreover, several phenomenological models describing the strain rate and temperature-dependent mechanical behaviour are validated.
TRIP steel grades in which aluminium is the main alloying element show high elongation values, whereas a high silicon content
results in an increase in strength. The widely used Johnson-Cook model can describe the behaviour of TRIP steels and provides
the opportunity to study its material and structural response. 相似文献
8.
The authors report record DC characteristics and RF performance of a power double heterostructure (DH) pseudomorphic (PM) InGaAs quantum well HFET. The device, with a 0.3×70 μm2 gate, exhibits an intrinsic transconductance as high as 720 mS/mm, a maximum current density of ~1 A/mm and delivers a state-of-the-art output power density of 1 W/mm with 5.7 dB linear gain and 38% power added efficiency at 33 GHz. A detailed analysis of the technological aspects and electrical characteristics of the device is proposed to explain these excellent performances 相似文献
9.
EM Stokely RW Parkey FJ Bonte KD Graham MJ Stone JT Willerson 《Canadian Metallurgical Quarterly》1976,120(2):433-434
Cardiac patients who have undergone 99mTc-stannous pyrophosphate (99mTc-PYP) myocardial imaging can be injected 24 hours later with 99mTc-pertechnetate (99mTc04) to assess left ventricular function. Reduction of 99mTc04 by tin remaining in the blood following the stannous pyrophosphate injection causes labeling of the red cells by 99mTc04 and the creation of a vascular tracer suitable for electrocardiographically gated imaging. 相似文献
10.
JT Willerson RW Parkey EM Stokely FJ Bonte S Lewis RA Harris G Blomqvist LR Poliner LM Buja 《Canadian Metallurgical Quarterly》1977,11(4):291-298
The dynamics of changes in serum lipids (free fatty acids, free glycerol, triglycerides, total cholesterol, and phospholipids) were studied in male Wistar rats irradiated in an open experimental field with a daily dose of 15.48 mC.kg.--1 (60 R) up to a total exposure of 774.0 mC. kg.--1 (3,000 R). The resulting changes occurred in several periods. Initial period of 0--7 days included a drop in triglyceride level and a rise in free glycerol, total cholesterol, and phospholipids in both control and irradiated rats. The period of 14--25 days marked the appearance of serum hyperlipaemia. Between 25--50 days, the levels of the different fractions oscillated and existing changes became more pronounced. The general level of serum lipids during continuous gamma-irradiation exceeded that found in controls. Changes in control animals from experimental field reflected the influence of a changed environment. The modifying factor affecting both irradiated and control rats was night fasting prior to sacrificing the animals and, probably, also the presence of an infradian rhythm in some serum lipid fractions. 相似文献