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1.
Ken Donaldson Paul JA Borm Vincent Castranova Mary Gulumian 《Particle and fibre toxicology》2009,6(1):13
In vitro studies with particles are a major staple of particle toxicology, generally used to investigate mechanisms and better understand
the molecular events underlying cellular effects. However, there is ethical and financial pressure in nanotoxicology, the
new sub-specialty of particle toxicology, to avoid using animals. Therefore an increasing amount of studies are being published
using in vitro approaches and such studies require careful interpretation. We point out here that 3 different conventional
pathogenic particle types, PM10, asbestos and quartz, which cause diverse pathological effects, have been reported to cause very similar oxidative stress
effects in cells in culture. We discuss the likely explanation and implications of this apparent paradox, and its relevance
for testing in nanotoxicology. 相似文献
2.
This paper deals with performance measures and performance indicators in the Impala electronic document ordering and delivery system for research libraries in Belgium and compares these with some international standards as, e.g., the ProLib/PI study commissioned by the European Commission.Performance measures: Costs (clearinghouse principle) Number of ILL requests made to other libraries Number of ILL requests made to other libraries without success Number of ILL requests made to other libraries with success Number of ILL requests received from other libraries Number of ILL requests received from other libraries and not satisfied Number of ILL requests received from other libraries that were satisfied Frequency asked titlesPerformance indicators: Success rate Borrowing-lending ratio per library Response times, split into several segments of the ILL-procedureThe article concludes with some indications for quality measurement in electronic document delivery where Impala will be able to measure the real supply times as perceived by the end user. 相似文献
3.
Batch sequencing and cooperation 总被引:1,自引:0,他引:1
Game theoretic analysis of sequencing situations has been restricted to manufacturing systems which consist of machines that can process only one job at a time. However, in many manufacturing systems, operations are carried out by batch machines which can simultaneously process multiple jobs. This paper aims to extend the game theoretical approach to the cost allocation problems arising from sequencing situations on systems that consist of batch machines. To analyze the allocation problem at hand, it focusses on the existence of core elements, convexity, and the Shapley value. 相似文献
4.
Peter Borm Anja De Waegenaere Carles Rafels Jeroen Suijs Stef Tijs Judith Timmer 《OR Spectrum》2001,23(2):265-281
The rate of return earned on a deposit can depend on its term, the amount of money invested in it, or both. Most banks, for example, offer a higher interest rate for longer term deposits. This implies that if one individual has capital available for investment now, but needs it in the next period, whereas the opposite holds for another individual, then they can both benefit from cooperation since it allows them to invest in a longer term deposit. A similar situation arises when the rate of return on a deposit depends on the amount of capital invested in it. Although the benefits of such cooperative behavior may seem obvious to all individuals, the actual participation of an individual depends on what part of the revenues he eventually receives. The allocation of the jointly earned benefits to the investors thus plays an important part in the stability of the cooperation. This paper provides a game theoretical analysis of this allocation problem. Several classes of corresponding deposit games are introduced. For each class, necessary conditions for a nonempty core are provided, and allocation rules that yield core-allocations are examined. 相似文献
5.
This study introduces dynamic displacement vision system (DDVS), which is applicable for imaging unapproachable structures using a hand-held digital video camcorder and is more economical than the existing contact and contactless measurement methods of dynamic displacement and deformation. This proposed DDVS method is applied to the Region of Interest (ROI) resizing and coefficient updating at each time step to improve the accuracy of the measurement from the digital image. Thus, after evaluating the algorithms conducted in this study by the static and dynamic verification, the measurement's usability by calculating the dynamic displacement of the masonry specimen, and the two-story steel frame specimen is evaluated under uniaxial seismic loading. The algorithm of the proposed method in this study, despite the relatively low resolution during frozen, slow, and seismic motions, has precision and usability that can replace the existing displacement transducer. Moreover, the method can be effectively applied to even fast behavior for multi-measurement positions like the seismic simulation test using large scale specimen. DDVS, using the consecutive images of the structures with an economic, hand-held digital video camcorder is a more economical displacement sensing concept than the existing contact and contactless measurement methods. 相似文献
6.
In this paper we introduce the weakly strict equilibrium for (mixed extensions of) finiten-person games. For those games we prove that our new concept is a strict refinement of the undominated Nash equilibrium concept. We show that their set of weakly strict equilibria is nonempty and coincides with their set of strict equilibria (when the latter is also non-empty) and we study the relation between our refinement and other noncooperative concepts.We thank Xunta de Galicia for financial support through project XUGA20702B93 相似文献
7.
Beekman F.J. Eijkman E.G.J. Viergever M.A. Borm G.F. Slijpen E.T.P. 《IEEE transactions on nuclear science》1993,40(1):31-39
An analytical expression for the point spread function (PSF) and the line spread function (LSF) of a parallel hole gamma camera is presented, for homogeneous media and for photons having mainly Compton interactions in the object. The PSF of scattered photons is described by convolving a zeroth-order modified Bessel function of the second kind with the unscattered PSF, which is approximated by a Gaussian. The complete PSF (scatter plus nonscatter) depends on the source distance ( z ) and depth (d ) of the source in the object. For convex-shaped emitting objects, the dependence of the PSF on the object contour can be incorporated by a simple correction. Thus, a complete mathematical model of the imaging of an activity distribution in a homogeneous medium is obtained. The model has been evaluated for 99mTechnetium line sources by using a LEAP collimator at various energy windows (ΔE ). It is shown that the model is valid to a high accuracy at ΔE =15%, for a large range of values of z and d 相似文献
8.
MJ Bruno JJ Borm FJ Hoek B Delzenne AF Hofmann JJ de Goeij EA van Royen TM van Gulik LT de Wit DJ Gouma DJ van Leeuwen GN Tytgat 《Canadian Metallurgical Quarterly》1997,84(7):952-956
BACKGROUND: A comparative study was performed between patients with exocrine pancreatic insufficiency after conventional pancreatoduodenectomy (Whipple's procedure) and pylorus-preserving pancreatoduodenectomy (PPPD). In these patients the pharmacodynamics of 2-mm enteric-coated pancreatin microspheres (ECPMs) and their gastric transit time in relation to that of a solid meal were investigated. The efficacy of ECPM preparations may differ after Whipple's procedure compared with PPPD, because the latter procedure does not include gastrectomy. METHODS: Gastric transit was assessed by double-isotope scintigraphy. A pancake meal was labelled with 99mTc. ECPMs were cold-labelled with 170Er and neutron activated shortly before ingestion to enable imaging with a gamma camera. Intraluminal pancreatic enzyme activity was assessed during a 6-h period with two indirect tests: the cholesteryl [14C]octanoate breath test and the N-benzoyl-L-tyrosyl-p-aminobenzoic acid-p-aminosalicylic acid (NBT-PABA-PAS) test. RESULTS: In patients who had Whipple's procedure, the gastric transit time of ECPMs and of the pancake meal was not significantly different. The outcome of the indirect pancreatic function tests during enzyme supplementation was comparable, and not significantly different, from that in healthy volunteers. In patients who had PPPD, however, the gastric transit time of microspheres was greatly delayed compared with that of the pancake meal (P < 0.05). Improvement in the outcome of the indirect pancreatic function tests during enzyme supplementation was much less and remained well below that of healthy volunteers (P < 0.05). CONCLUSION: In cases of exocrine pancreatic insufficiency after Whipple's procedure, 2-mm ECPM treatment adequately restores pancreatic enzyme activity. Following PPPD, however, ECPM treatment is often ineffective because the microspheres are retained in the stomach. In these patients, use of conventional powdered pancreatin enzyme preparations may improve the efficacy of treatment. 相似文献
9.
PJ Borm RP Schins TJ Derhaag I Kant TH Jorna 《Canadian Metallurgical Quarterly》1996,109(4):1078-1085
Grain dust is well known to cause both acute and chronic respiratory disorders, and endotoxins are considered key components in this. Since endotoxins are known to elicit proinflammatory mediators, we investigated cytokine (tumor necrosis factor [TNF], interleukin-6, interleukin-8) release and a number of proinflammatory and anti-inflammatory proteins (soluble TNF receptors, lipopolysaccharide (LPS) binding protein, bactericidal permeability increasing protein (BPI), C-reactive protein) in plasma of workers exposed to grain dust. In two surveys during 1 week, lung function was measured daily before and after the shift, using flow-volume curves and/or forced oscillation measurements. On Monday and Friday, blood samples (30 mL) were drawn and cytokine release was determined by enzyme-linked immunosorbent assay in supernatant of isolated monocytes or whole blood culture, either unstimulated or on the ex vivo stimulation with 3 ng/mL or 1,000 ng/mL endotoxin. Individual exposures were determined from stationary dust measurements at every workplace combined with personal task analysis during all shifts. In both surveys, no cross-week change in lung function parameters was observed. In the first survey (average exposure: 20.2 mg/m3), monocyte spontaneous TNF release was increased sevenfold cross week (p<0.001) and was significantly related both to individual dust exposure (r=0.62) of that week and the increase in soluble TNF receptor 75 kD (r=0.85). In the second survey, where average exposure was much lower (3.67 mg/m3), impedance parameters indicated a significant improvement of airway function, and cross-week changes in inflammatory markers were minimal. Therefore, we conclude that inflammatory events can be used to monitor adverse respiratory effects of moderate grain dust exposure. 相似文献
10.
Hojung?ChaEmail author Jongmin?Lee Jongho?Nang Sung-Yong?Park Jin-Hwan?Jeong Chuck?Yoo Jin-Young?Choi 《Wireless Networks》2005,11(3):265-274
This paper presents a case of video streaming system for mobile phone which has actually been implemented and deployed for commercial services in CDMA2000 1X cellular phone networks. As the computing environment and the network connection of cellular phones are significantly different from the wired desktop environment, the traditional desktop streaming method is not applicable. Therefore, a new architecture is required to suit the successfully streaming in the mobile phone environment. We have developed a very lightweight video player for use in mobile phone and the related authoring tool for the player. The streaming server has carefully been designed to provide high efficiency, reliability and scalability. Based on a specifically-designed suite of streaming protocol, the server employs an adaptive rate control mechanism which transmits the media packets appropriately into the network according to the change in network bandwidth.Hojung Cha is currently a professor in computer science at Yonsei University, Seoul, Korea. His research interests include multimedia computing system, multimedia communication networks, wireless and mobile communication systems and embedded system software. He received his B.S. and M.S. in computer engineering from Seoul National University, Korea, in 1985 and 1987, respectively. He received his Ph.D. in computer science from the University of Manchester, England, in 1991.Jongmin Lee is a Ph.D. candidiate in computer science at Yonsei University, Seoul, Korea. His research interests include wireless multimedia system, QoS architecture, multimedia communication networks. He received his B.S. and M.S. in computer science from Kwangwoon University in 1999 and 2001, respectively.Jongho Nang is a professor in the Department of Computer Science at Sogang University. He received his B.S. degree from Sogang University, Korea, in 1986 and M.S. and Ph.D. degree from KAIST, in 1988 and in 1992, respectively. His research interests are in the field of multimedia systems, digital video library, and Internet technologies. He is a member of KISS, ACM, and IEEE.Sung-Yong Park is an associate professor in the Department of Computer Science at Sogang University, Seoul, Korea. He received his B.S. degree in computer science from Sogang University, and both the M.S. and Ph.D. degrees in computer science from Syracuse University. From 1987 to 1992, he worked for LG Electronics, Korea, as a research engineer. From 1998 to 1999, he was a research scientist at Telcordia Technologies (formerly Bellcore) where he developed network management software for optical switches. His research interests include high performance distributed computing and systems, operating systems, and multimedia.Jin-Hwan Jeong received the B.S. and M.S. degrees in computer science from Korea University, Seoul, Korea, in 1997, and 1999, respectively. He is currently in Ph.D. course at Korea University. His research interests include video processing for thin devices, multimedia streaming and operating systems.Chuck Yoo received the B.S. degree in electronics engineering from Seoul National University, Seoul, Korea and the M.S. and Ph.D. in computer science in University of Michigan. He worked as a researcher in Sun Microsystems Lab. from 1990 to 1995. He joined the Computer Science and Enginnering Department, Korea University, Seoul, Korea in 1995, where he is currently a professor. His research interests include high performance network, multimedia streaming, and operating systems.Jin-Young Choi received the B.S. degree from Seoul National University, Seoul, Korea, in 1982, the M.S. degree from Drexel University in 1986, and the Ph.D. degree from University of Pennsylvania, in 1993. He is currently a professor of Computer Science and Engineering Department, Korea University, Seoul, Korea. His current research interests are in real-time computing, formal methods, programming languages, process algebras, security, software engineering, and protocol engineering. 相似文献