Effects of viscosity on the bitterness and astringency of grape seed tannin

To examine the separate effects of viscosity and sweetness on astringency, aqueous solutions of grape seed tannin (GST) were thickened with carboxymethyl cellulose (CMC) from 2 to 45 cP (experiment 1) or sweetened with 0 to 1.8 g/L aspartame (experiment 2). Trained subjects continuously rated astringency and bitterness in duplicate. Subjects were categorized by the salivary flow induced by citric acid and ability to taste n-propyl thiouracil (PROP). In experiment 1, maximum intensity and total duration of astringency were significantly decreased as viscosity rose, although time to maximum intensity of astringency was not affected. Maximum intensity and total duration of bitterness were not significantly affected by increasing viscosity; however, the onset of bitterness was significantly delayed. In experiment 2, increasing sweetness had no affect on any astringency parameter, although maximum intensity of bitterness was significantly decreased. Neither PROP nor salivary flow-status had any effect on perception of bitterness or astringency in either experiment.     

A well-based reverse-phase protein array applicable to extracts from formalin-fixed paraffin-embedded tissue

Proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tissue offers significant diagnostic utility but is complicated due to the high level of covalently crosslinked proteins arising from formalin fixation. To address these challenges, we developed a reliable protein extraction method for FFPE tissue, based on heat-induced antigen retrieval within a pressure cooker. The protein extraction yield from archival FFPE tissue section is approximately 90% of that recovered from frozen tissue. This method demonstrates preservation of immunoreactivity and recovery of full-length proteins by Western blotting. Additionally, we developed a well-based RP protein array platform utilizing an electrochemiluminescence detection system. Protein samples derived from FFPE tissue by means of laser capture dissection, with as few as 500 shots demonstrate measurable signal differences for different proteins. The lysates coated to the array plate, remain stable over 1?month at room temperature. Theses data suggest that this new protein-profiling platform coupled with the protein extraction method can be used for molecular profiling analysis in FFPE tissue, and contribute to the validation and development of biomarkers in clinical studies.     

Optimizing Chain Topology of Bottle Brush Copolymer for Promoting the Disorder-to-Order Transition

The order-disorder transitions (ODT) of core-shell bottle brush copolymer and its structural isomers were investigated by dissipative particle dynamics simulations and theoretically by random phase approximation. Introducing a chain topology parameter λ which parametrizes linking points between M diblock chains each with N monomers, the degree of incompatibility at ODT ((χN)ODT; χ being the Flory–Huggins interaction parameter between constituent monomers) was predicted as a function of chain topology parameter (λ) and the number of linked diblock chains per bottle brush copolymer (M). It was found that there exists an optimal chain topology about λ at which (χN)ODT gets a minimum while the domain spacing remains nearly unchanged. The prediction provides a theoretical guideline for designing an optimal copolymer architecture capable of forming sub-10 nm periodic structures even with non-high χ components.     

Analysis of PLR for Shared Switch Fabrics

A modular upgrade design for packet transport switch nodes is presented where packet loss is dramatically reduced by intra‐module and inter‐module buffer sharing. This modular design offers significant cost and power reduction in a high‐data‐rate system where buffers are highly costly and power‐greedy.     

Photonic Crystal Palette of Binary Block Copolymer Blends for Full Visible Structural Color Encryption

Structural color (SC) arising from a periodically ordered self-assembled block copolymer (BCP) photonic crystal (PC) is useful for reflective-mode sensing displays owing to its capability of stimuli-responsive structure alteration. However, a set of PC inks, each providing a precisely addressable SC in the full visible range, has rarely been demonstrated. Here, a strategy for developing BCP PC inks with tunable structures is presented. This involves solution-blending of two lamellar-forming BCPs with different molecular weights. By controlling the mixing ratio of the two BCPs, a thin 1D BCP PC film is developed with alternating in-plane lamellae whose periodicity varies linearly from ≈46 to ≈91 nm. Subsequent preferential swelling of one-type lamellae with either solvent or non-volatile ionic liquid causes the photonic band gap of the films to red-shift, giving rise to full-visible-range SC correlated with the pristine nanostructures of the blended films in both liquid and solid states. The BCP PC palette of solution-blended binary solutions is conveniently employed in various coating processes, allowing facile development of BCP SC on the targeted surface. Furthermore, full-color SC paintings are realized with their transparent PC inks, facilitating low-power pattern encryption.     

Parametric GLRT for Multichannel Adaptive Signal Detection

This paper considers the problem of detecting a multichannel signal in the presence of spatially and temporally colored disturbance. A parametric generalized likelihood ratio test (GLRT) is developed by modeling the disturbance as a multichannel autoregressive (AR) process. Maximum likelihood (ML) parameter estimation underlying the parametric GLRT is examined. It is shown that the ML estimator for the alternative hypothesis is nonlinear and there exists no closed-form expression. To address this issue, an asymptotic ML (AML) estimator is presented, which yields asymptotically optimum parameter estimates at reduced complexity. The performance of the parametric GLRT is studied by considering challenging cases with limited or no training signals for parameter estimation. Such cases (especially when training is unavailable) are of great interest in detecting signals in heterogeneous, fast changing, or dense-target environments, but generally cannot be handled by most existing multichannel detectors which rely more heavily on training at an adequate level. Compared with the recently introduced parametric adaptive matched filter (PAMF) and parametric Rao detectors, the parametric GLRT achieves higher data efficiency, offering improved detection performance in general.     

Base station location in a cellular CDMA system

We consider a cellular CDMA system in which blocking is enforced when the relative interference exceeds a certain threshold level. This paper addresses a radio network design problem in such a CDMA system. Given the data of call‐traffic distributed over the service area and potential sites of base stations, the objective of the problem is to locate base stations so as to minimize the associated cost for establishing base stations while keeping the probability of blocking under control. We develop an efficient algorithm for solving the design problem. Computational experiments with real‐world data are conducted to show both the efficiency and the practicality of the proposed design method. This revised version was published online in August 2006 with corrections to the Cover Date.     

Pipelined Scheduling of Functional HW/SW Modules for Platform‐Based SoC Design

We developed a pipelined scheduling technique of functional hardware and software modules for platform‐based system‐on‐a‐chip (SoC) designs. It is based on a modified list scheduling algorithm. We used the pipelined scheduling technique for a performance analysis of an MPEG4 video encoder application. Then, we applied it for architecture exploration to achieve a better performance. In our experiments, the modified SoC platform with 6 pipelines for the 32‐bit dual layer architecture shows a 118% improvement in performance compared to the given basic SoC platform with 4 pipelines for the 16‐bit single‐layer architecture.