Toward the development of interactive virtual dissection with haptic feedback

Traditional, hands-on dissection of an animal is common practice in many classrooms to aid in the study of anatomy and biology. More specifically, virtual dissection environments have been developed making it possible to study the inner workings of animals without cutting them up. In this paper, we present a novel virtual reality dissection simulator, where a user can dissect an animal (i.e. frog) and its organs using a 3D force feedback haptic device. The simulator uses force feedback as part of a multimodal cue to provide guidance and performance feedback to the user. This paper highlights methodologies which are used for addressing some of the key challenges involved in designing and developing simulators, such as: modelling and mechanics of deformation, collision detection between multiple deformable bodies, and haptic feedback.     

Attitude of Iranian physicians and nurses toward a clinical decision support system for pulmonary embolism and deep vein thrombosis

This research project sought to design and implement a computerized clinical decision support system (CDSS) that was able to identify patients who were at risk of pulmonary embolism (PE) and deep vein thrombosis (DVT), as well as produce reminders for prophylactic action for these diseases. The main purpose of the CDSS was to attempt to reduce the morbidity and mortality caused by embolism and thrombosis in patients admitted to hospitals. After implementation of this system in one of the large educational hospitals of Iran, a standard questionnaire was used, and interviews were conducted with physicians and nurses to evaluate the performance of the designed system for reducing the incidence of pulmonary embolism and thrombosis. From physicians and nurses’ point of view, a system which assists the medical staff in making better decisions regarding patient care, and also reminds pulmonary embolism and thrombosis preventive procedures with timely warnings, can influence patient care quality improvement and lead to the improved performance of the medical staff in preventing the incidence of pulmonary embolism and thrombosis.     

Capacitive micromachined ultrasonic transducers: next-generation arrays for acoustic imaging?

Piezoelectric materials have dominated the ultrasonic transducer technology. Recently, capacitive micromachined ultrasonic transducers (CMUTs) have emerged as an alternative technology offering advantages such as wide bandwidth, ease of fabricating large arrays, and potential for integration with electronics. The aim of this paper is to demonstrate the viability of CMUTs for ultrasound imaging. We present the first pulse-echo phased array B-scan sector images using a 128-element, one-dimensional (1-D) linear CMUT array. We fabricated 64- and 128-element 1-D CMUT arrays with 100% yield and uniform element response across the arrays. These arrays have been operated in immersion with no failure or degradation in performance over the time. For imaging experiments, we built a resolution test phantom roughly mimicking the attenuation properties of soft tissue. We used a PC-based experimental system, including custom-designed electronic circuits to acquire the complete set of 128 x 128 RF A-scans from all transmit-receive element combinations. We obtained the pulse-echo frequency response by analyzing the echo signals from wire targets. These echo signals presented an 80% fractional bandwidth around 3 MHz, including the effect of attenuation in the propagating medium. We reconstructed the B-scan images with a sector angle of 90 degrees and an image depth of 210 mm through offline processing by using RF beamforming and synthetic phased array approaches. The measured 6-dB lateral and axial resolutions at 135 mm depth were 0.0144 radians and 0.3 mm, respectively. The electronic noise floor of the image was more than 50 dB below the maximum mainlobe magnitude. We also performed preliminary investigations on the effects of crosstalk among array elements on the image quality. In the near field, some artifacts were observable extending out from the array to a depth of 2 cm. A tail also was observed in the point spread function (PSF) in the axial direction, indicating the existence of crosstalk. The relative amplitude of this tail with respect to the mainlobe was less than -20 dB.     

Investigation of pointed domes—II. Experiment

The aim of the experiment was to study the behavior of pointed domes subjected to point loading at the vertex. A concrete dome reinforceed with 1 mm bars running both in the meridional and parallel circular direction was constructed. Electrical resistance strain gages were mounted at several locations along the meridional and parallel direction of the shell both inside and outside. The structure was loaded within the elastic limit.The experimental values of membrane stress field are calculated and compared with the theoretical values as is described in part I of this report. (see pp. 81–85). These results are in close agreement in regions some distance away from the lower boundary and the pointed apex. But the difference between the two results becomes noticeable near the lower boundary and the vertex of the dome. Further analysis of the experiment findings indicates that the bending strain field is slight at regions that are some distance away from the lower boundary and to the apex of the dome.     

Quantification of Protein‐Induced Membrane Remodeling Kinetics In Vitro with Lipid Multilayer Gratings

The dynamic self‐organization of lipids in biological systems is a highly regulated process that enables the compartmentalization of living systems at micro‐ and nanoscopic scales. Consequently, quantitative methods for assaying the kinetics of supramolecular remodeling such as vesicle formation from planar lipid bilayers or multilayers are needed to understand cellular self‐organization. Here, a new nanotechnology‐based method for quantitative measurements of lipid–protein interactions is presented and its suitability for quantifying the membrane binding, inflation, and budding activity of the membrane‐remodeling protein Sar1 is demonstrated. Lipid multilayer gratings are printed onto surfaces using nanointaglio and exposed to Sar1, resulting in the inflation of lipid multilayers into unilamellar structures, which can be observed in a label‐free manner by monitoring the diffracted light. Local variations in lipid multilayer volume on the surface is used to vary substrate availability in a microarray format. A quantitative model is developed that allows quantification of binding affinity (K _D) and kinetics (k_on and k_off). Importantly, this assay is uniquely capable of quantifying membrane remodeling. Upon Sar1‐induced inflation of single bilayers from surface supported multilayers, the semicylindrical grating lines are observed to remodel into semispherical buds when a critical radius of curvature is reached.     

Analysis of transport phenomena within PEM fuel cells – An analytical solution

Transport phenomena within PEM fuel cells are investigated and a comprehensive analytical solution is presented. The methodology couples the transport within the fuel cell supply channels and the substrate which is composed of five different layers. The layers are all treated as macroscopically homogeneous porous media with uniform morphological properties such as porosity and permeability. The locally volume-averaged equations are employed to solve for transport through the porous layers. The problem encompasses complex interfacial transport phenomena involving several porous–porous as well as porous–fluid interfaces. Chemical reactions within the catalyst layers are also included. The method of matched asymptotic expansions is employed to solve for the flow field and species concentration distributions. Throughout the analysis, the choice of the gauge parameters involved in the perturbation solutions for velocity and concentration is found to be inherently tied to the physics of the problem and therefore an important physical metric. The analytical solution is found to be in excellent agreement with prior computational simulations. The analytical results are used to investigate several aspects of transport phenomena and their substantial role in PEM fuel cell operation. The solution presented in this work provides the first comprehensive analytical solution representing fuel cell transport phenomena.     

On the buckling of cylindrical shells with through cracks under axial load

Presence of cracks or similar imperfections can considerably reduce the buckling load of a shell structure. In this paper, the buckling of cylindrical shells with through cracks has been studied. A general finite element model has been proposed, verified and applied to some novel cracked shell buckling problems for which documented results are not available. A special purpose program has been developed for generating finite elements models of cylindrical shells with cracks of varying length and orientation. The buckling behavior of cracked cylinders in tension and compression has been studied. The results of the analysis are presented in parametric form when it seems to be appropriate. Sensitivity of the buckling load to the crack length and orientation has also been investigated.