Hydrolytic degradation of ionically cross-linked polyphosphazene microspheres

The hydrolytic degradation of gel microspheres based on calcium cross-linked phosphazene polyelectrolytes, poly[di(carboxylatophenoxy)phosphazene] (PCPP) and poly[(carboxylatophenoxy) (glycinato)phosphazene] (PCGPP), was investigated. These microspheres are of importance as carriers in protein and cell encapsulation. Both PCPP and PCGPP ionotropic polyphosphazene hydrogels are degradable in an aqueous environment (pH 7.4, 37°C). The degradation rates can be increased by incorporation of hydrolysis sensitive glycinato groups as the pendant structures in the polymer (PCGPP). Hydrolysis of these polymer hydrogels led to low molecular weight (<1,000 Da) products. The erosion and molecular weight profiles varied also according to the molecular weight of the polyphosphazene constituting the gel beads. Another approach to affect the degradation rates consists of coating microspheres with poly-L -lysine. Ionotropic polyphosphazene hydrogels have potential as biodegradable devices for controlled drug delivery systems. © 1994 John Wiley & Sons, Inc.     

Editor’s corner

Editor’s corner     

Object-based crop identification using multiple vegetation indices, textural features and crop phenology

Crop identification on specific parcels and the assessment of soil management practices are important for agro-ecological studies, greenhouse gas modeling, and agrarian policy development. Traditional pixel-based analysis of remotely sensed data results in inaccurate identification of some crops due to pixel heterogeneity, mixed pixels, spectral similarity, and crop pattern variability. These problems can be overcome using object-based image analysis (OBIA) techniques, which incorporate new spectral, textural and hierarchical features after segmentation of imagery. We combined OBIA and decision tree (DT) algorithms to develop a methodology, named Object-based Crop Identification and Mapping (OCIM), for a multi-seasonal assessment of a large number of crop types and field status.In our approach, we explored several vegetation indices (VIs) and textural features derived from visible, near-infrared and short-wave infrared (SWIR) bands of ASTER satellite scenes collected during three distinct growing-season periods (mid-spring, early-summer and late-summer). OCIM was developed for 13 major crops cultivated in the agricultural area of Yolo County in California, USA. The model design was built in four different scenarios (combinations of three or two periods) by using two independent training and validation datasets and the best DTs resulted in an error rate of 9% for the three-period model and between 12 and 16% for the two-period models. Next, the selected DT was used for the thematic classification of the entire cropland area and mapping was then evaluated applying the confusion matrix method to the independent testing dataset that reported 79% overall accuracy. OCIM detected intra-class variations in most crops attributed to variability from local crop calendars, tree-orchard structures and land management operations. Spectral variables (based on VIs) contributed around 90% to the models, although textural variables were necessary to discriminate between most of the permanent crop-fields (orchards, vineyard, alfalfa and meadow). Features extracted from late-summer imagery contributed around 60% in classification model development, whereas mid-spring and early-summer imagery contributed around 30 and 10%, respectively. The Normalized Difference Vegetation Index (NDVI) was used to identify the main groups of crops based on the presence and vigor of green vegetation within the fields, contributing around 50% to the models. In addition, other VIs based on SWIR bands were also crucial to crop identification because of their potential to detect field properties like moisture, vegetation vigor, non-photosynthetic vegetation and bare soil. The OCIM method was built using interpretable rules based on physical properties of the crops studied and it was successful for object-based feature selection and crop identification.     

Coping styles associated with psychological adjustment to advanced breast cancer.

The aim of this study was to determine whether psychological adjustment to advanced breast cancer was positively associated with expressing emotion and adopting a fighting spirit and negatively associated with denial and fatalism. Total mood disturbance on the Profile of Mood States was used as the measure of psychological adjustment. The Courtauld Emotional Control Scale measured emotional expression, and the Mental Adjustment to Cancer measured fighting spirit, denial, and fatalism. The sample included 101 women with a diagnosis of metastatic or recurrent breast cancer. Fighting spirit and emotional expressiveness were found to be associated with better adjustment. No association was found between mood disturbance and denial or fatalism. Because this was a cross-sectional study, no conclusions regarding a causal relationship between adjustment and emotional expressiveness or adjustment and fighting spirit were possible. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of ischaemia and reperfusion on the intracellular concentration of taurine and glutamine in the hearts of patients undergoing coronary artery surgery

Taurine and glutamine are the most abundant intracellular free amino acids in mammalian hearts where changes in their intracellular concentrations are likely to influence a number of cellular activities. In this study we investigated the effects of ischaemia and reperfusion on the intracellular concentrations of taurine and glutamine in the hearts of patients undergoing coronary artery bypass surgery using cold crystalloid or cold blood cardioplegic solutions. Ischaemic arrest (30 min), using cold crystalloid cardioplegic solution (n = 19), decreased the intracellular concentrations (micromol/g wet weight) of taurine (from 9.8 +/- 0.8 to 7.7 +/- 0.7, P < 0.05) and glutamine (8.7 +/- 0.5 to 7.2 +/- 0.6). After 20 min of normothermic reperfusion the fall in taurine and glutamine was maintained (7.5 +/- 0.5 and 7.4 +/- 0.7 for taurine and glutamine respectively). Myocardial ischaemic arrest with cold blood cardioplegic solution (n = 16) did not cause a significant fall in tissue taurine or glutamine. However, on reperfusion there was a marked fall in the intracellular concentrations of taurine (9.4 +/- 0.5 to 6.5 +/- 0.7) and glutamine (8.0 +/- 0.7 to 5.8 +/- 0.4). The fall in amino acids was associated with a fall in ATP and a rise in tissue lactate. This work demonstrates that irrespective of the cardioplegic solution used to arrest the heart, there is a marked fall in tissue taurine and glutamine which may influence the extent of recovery following surgery. The fall in taurine is largely due to efflux whereas changes in glutamine are due to both transport and metabolism. Ischaemia, hypothermia and changes in the transmembrane concentration gradients are the likely factors responsible for the changes in tissue amino acids.     

Effect of Humidity on NPK Fertilizer Drying

ABSTRACT

The drying process within rotary coolers during the manufacture of granular NPK fertilizer plays an important role in the production of fertilizer granules possessing both a low moisture content and low caking propensity. A theory for fertilizer drying has been developed which takes into account the low critical relative humidity of complex fertilizer found at high temperature. The theory proposes that the gradient between the partial vapour pressure of moisture in the air and the vapour pressure moisture adjacent to the surface of the fertilizer granule, is the rate controlling stage in the drying of hot granular fertilizer rather than the internal diffusion of moisture within the particle.