Review: the latest advances in biomedical applications of chitosan hydrogel as a powerful natural structure with eye-catching biological properties

Journal of Materials Science - Chitosan is one of the natural cationic polymers with unique properties such as non-toxicity, biodegradability, biocompatibility, environmentally friendly that has...     

An adaptive tracking problem for a family of retarded time-delay plants

Most of the existing switching control techniques are developed specifically for finite-dimensional linear time-invariant (LTI) systems. In many practical applications, however, it is essential to take time delay into consideration in the modelling as the control system can be highly sensitive to delay. In this paper, a multi-model switching control algorithm is proposed for retarded time-delay systems. It is assumed that the plant is represented by a family of known multi-input multi-output, observable, LTI models with multiple delays in the states, and that corresponding to each model in the known family, there exists a high-performance finite-dimensional LTI controller. In addition, it is supposed that a bound on the magnitude of the external inputs and disturbances is available. It is then shown that the proposed switching controller can stabilize the uncertain system, and that under some mild conditions, output tracking can be achieved in the given problem setting. Copyright © 2007 John Wiley & Sons, Ltd.     

Cast titanium as implant material

The tissue response in rats to implants made of machined and cast titanium was evaluated after 1 and 12 weeks. The implants consisted of a circular plate portion, located in the abdominal wall, and a cylindrical rod portion protruding into the peritoneal cavity. The chemical and topographical surface properties of the two types of implants differed considerably. The implants with surrounding tissue were processed en bloc for light and electron microscopy. The bulk metal was removed by an electrochemical procedure which permitted the sectioning and evaluation of the intact implant-tissue interface. The general distribution of macrophages and fibroblasts was the same around the plate portion of both types of implants. Macrophages constituted the predominating cell type with the highest concentration in the innermost cell zone closest to the implant. The number of macrophages per section area was significantly higher around machined implants. Multinuclear giant cells, always located at the implant surface, were more frequent around cast implants. The majority of the intraperitoneal rod portions were partially (1 week) or completely (12 weeks) covered by tissue; partial or complete overgrowth of tissue was rare for machined rod portions. Imaging electron energy loss spectroscopy demonstrated the presence of titanium in macrophages in the peripheral part of the tissue capsule around cast, but not machined implants. We conclude that the tissue responses to the two types of titanium implants differed considerably in the two biological environments (soft tissue in abdominal wall; peritoneal cavity) examined and that the response in one environment does not predict the response in the other. We also believe that improvements have to be made in the casting procedure in order to reduce surface roughness and contamination before cast implants can be used in clinical applications.     

Seismic safety of lifelines—an optimum design method

Lifeline systems are vulnerable to two types of hazards arising from potential earthquake sources. These are the hazard of a fault-rupture strike on elements of a lifeline system and the hazard of overstress induced in different elements of the system because of the ground vibration. An optimum design method is presented in this paper for the design of a lifeline system for a maximum accepted probability of failure because of any of the two modes of failure. The method may be used to determine an optimum path between a number of fixed points which represent supply or demand stations in the system.     

A genetic algorithm for the optimisation of assembly sequences

This paper describes a Genetic Algorithm (GA) designed to optimise the Assembly Sequence Planning Problem (ASPP), an extremely diverse, large scale and highly constrained combinatorial problem. The modelling of the ASPP problem, which has to be able to encode any industrial-size product with realistic constraints, and the GA have been designed to accommodate any type of assembly plan and component. A number of specific modelling issues necessary for understanding the manner in which the algorithm works and how it relates to real-life problems, are succinctly presented, as they have to be taken into account/adapted/solved prior to Solving and Optimising (S/O) the problem. The GA has a classical structure but modified genetic operators, to avoid the combinatorial explosion. It works only with feasible assembly sequences and has the ability to search the entire solution space of full-scale, unabridged problems of industrial size. A case study illustrates the application of the proposed GA for a 25-components product.     

Robust Stabilizability Verification of Polynomially Uncertain LTI Systems

This paper investigates the stabilizability of uncertain linear time-invariant (LTI) systems via structurally constrained controllers. First, an LTI uncertain system is considered whose state-space matrices depend polynomially on the uncertainty vector, defined over some region. It is shown that if the system is stabilizable by a structurally constrained controller in one point belonging to the region, then it is stabilizable by a controller with the same structure in all points belonging to the region, except for those located on an algebraic variety. Thus, if a system is stabilizable via a constrained controller at the nominal point, then it is almost always stabilizable at any operating point around the nominal model. It is also shown how this algebraic variety (or the dominant subvariety of it) can be computed efficiently. The results obtained in this paper encompass a broad range of the existing results in the literature on robust stability of the LTI systems, in addition to new ones.