A model for the carbohydrate recognition domain (CRD) and combining site of the human asialoglycoprotein (ASGP) receptor has been computed on the basis of the close sequence homology with the mannose-binding lectin (MBP), whose three-dimensional structure in complex with a ligand has been determined by crystallographic methods (Weis, W.I.; Drickamer, K.; Hendrickson, W.A. Nature 1992, 360: 127). Within the limitations of modeling methods, the model is compatible with data on ligand binding of the family C-type lectins, of which the MBP and the ASGP receptor are members. The model derived can serve as a guide for designing site-directed mutagenesis experiments in order to further elucidate the origins of specificity of the ASGP receptor toward galactose. In particular, the model focuses attention on the possible role of position 207 (MBP sequence numbering) in promoting galactose binding. 相似文献
In this paper, results of the one-dimensional (1D) digital filtering are extended to the two-dimensional (2D) case. It introduces
a technique and an algorithm for the computation of the product H(z1,z2)H(z1−1,z2−1). The technique is used to find a minimum phase transfer function of a 2D system such that the previous product matches a
given correlation sequence. The algorithm requires less arithmetic operations than the traditional methods. The former is
based on a matrix formulation of the product, which is used to investigate the 2D partial fraction decomposition (PFD) and
stability. 相似文献
In this work, first we estimate all the system’s state vector, with guarantied precision, for a category of second order underactuated mechanical systems (UMS), exploiting the triangular observer (TO) model that suits to the structure of these systems. Then we propose a sliding mode controller (SMC). The latter uses the estimated states given by the observer. The underactuated system is decomposed into two subsystems, where the sliding surface is constructed in two levels for each subsystem. The proposed controller guaranties the tracking performances, with minimization of chattering phenomenon, due to the constructed observer, even for system with uncertainties. Simulation results show the effectiveness of this strategy of control.
Interval arithmetic is an elegant tool for practical work with inequalities, approximate numbers, error bounds, and more generally with certain convex and bounded sets. In this section we give a number of simple examples showing where intervals and ranges of functions over intervals arise naturally. Interval mathematics is a generalization in which interval numbers replace real numbers, interval arithmetic replaces real arithmetic, and interval analysis replaces real analysis. Interval is limited by two bounds: lower bound and upper bound. The present paper introduces some of the basic notions and techniques from interval analysis needed in the sequel for presenting various uses of interval analysis in electric circuit theory and its applications. In this article we address the representation of uncertain and imprecise information, the interval arithmetic and its application to electrical circuits. 相似文献
New techniques for the evaluation of complex polynomials in one and two variables are presented. Polynomials arise in many areas of network analysis, synthesis, etc., and their evaluations are time consuming. This paper introduces new algorithms that are straightforward and require fewer arithmetic operations which are easily programmed. 相似文献
The simulation techniques, languages or models best suited for a particular simulation study depend upon the characteristics of the system and the programming skill of the individual conducting the study. This paper identifies, defines, evaluates and classifies a spectrum of simulation techniques that are applicable to weapons systems analysis and air defense weaponry. 相似文献
Intelligent Service Robotics - This paper proposes a high-performance control strategy for an efficient manipulation of non-holonomic mobile robots in environments cluttered with static obstacles.... 相似文献