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1.
Service composition for generic service graphs 总被引:1,自引:0,他引:1
Service composition is a promising approach to multimedia service provisioning, due to its ability to dynamically produce new multimedia content, and to customize the content for individual client devices. Previous research work has addressed various aspects of service composition such as composibility, QoS-awareness, and load balancing. However, most of the work has focused on applications where data flow from a single source is processed by intermediate services and then delivered to a single destination. In this paper, we address the service composition problem for multimedia services that can be modeled as directed acyclic graphs (DAGs). We formally define the problem and prove its NP hardness. We also design a heuristic algorithm to solve the problem. Our simulation results show that the algorithm is effective at finding low-cost composition solutions, and can trade off computation overhead for better results. When compared with a hop-by-hop approach for service composition, our algorithm can find composition solutions that aress 10% smaller in cost, even when the hop-by-hop approach uses exhaustive searches. 相似文献
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Klara Suchan Justus Just Pascal Beblo Carolin Rehermann Aboma Merdasa Roland Mainz Ivan G. Scheblykin Eva Unger 《Advanced functional materials》2023,33(3):2206047
Photo- and charge-carrier-induced ion migration is a major challenge when utilizing metal halide perovskite semiconductors for optoelectronic applications. For mixed iodide/bromide perovskites, the compositional instability due to light- or electrical bias induced phase-segregation restricts the exploitation of the entire bandgap range. Previous experimental and theoretical work suggests that excited states or charge carriers trigger the process, but the exact mechanism is still under debate. To identify the mechanism and cause of light-induced phase-segregation phenomena, the full compositional range of methylammonium lead bromide/iodide samples are investigated, MAPb(BrxI1-x)3 with x = 0…1, by simultaneous in situ X-ray diffraction (XRD) and photoluminescence (PL) spectroscopy during illumination. The quantitative comparison of composition-dependent in situ XRD and PL shows that at excitation densities of 1 sun, only the initial stage of photo-segregation is rationalized with the previously established thermodynamic models. However, a progression of the phase segregation is observed that is rationalized by considering long-lived accumulative photo-induced material alterations. It is suggested that (additional) photo-induced defects, possibly halide vacancies and interstitials, need to be considered to fully rationalize light-induced phase segregation and anticipate the findings to provide crucial insight for the development of more sophisticated models. 相似文献
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Klara Nahrstedt Zhenyu Yang Wanmin Wu Ahsan Arefin Raoul Rivas 《Multimedia Tools and Applications》2011,51(2):593-623
In the recent past we have seen a boom of distributed interactive multimedia environments which use multiple correlated media
sensors, multi-view displays, and advanced haptic-audio-visual user interfaces for teleimmersive gaming, business meetings
and other collaborative activities. However, when we investigate the emerging teleimmersive environments closer, we realize
that their overall session management, including end-to-end session setup, establishment and run-time management are not appropriate
for the new demands that these environments present. These environments are cyber-physical rooms that demand (a) large scale of multi-sensory devices across geographically-distributed locations and (b) interaction with each other in synchronous and real-time manner. To deal with the new teleimmersive demands, we present a new session management design with (a) session initiation protocol(s) that understand media correlations, (b) view-based multi-stream topology establishment among multiple parties, (c) efficient, light-weight and distributed session monitoring with querying and debugging capabilities, (d) flexible view-based session adaptation with efficient topology adjustments, and (e) light-weighted and consistent session tear-down protocols. The presented design of the next generation session management protocols, services, algorithms and data structures is based
on our extensive experiences with building 3D teleimmersive interactive systems, experimenting with high impact teleimmersive
applications and deploying such environments at various venues. 相似文献
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Anna Siskova Jan Kral Jana Drabova Klara Cervena Kristyna Tomasova Jiri Jungwirth Tomas Hucl Pavel Kohout Sandra Summerova Ludmila Vodickova Pavel Vodicka Veronika Vymetalkova 《International journal of molecular sciences》2022,23(14)
A colorectal adenoma, an aberrantly growing tissue, arises from the intestinal epithelium and is considered as precursor of colorectal cancer (CRC). In this study, we investigated structural and numerical chromosomal aberrations in adenomas, hypothesizing that chromosomal instability (CIN) occurs early in adenomas. We applied array comparative genomic hybridization (aCGH) to fresh frozen colorectal adenomas and their adjacent mucosa from 16 patients who underwent colonoscopy examination. In our study, histologically similar colorectal adenomas showed wide variability in chromosomal instability. Based on the obtained results, we further stratified patients into four distinct groups. The first group showed the gain of MALAT1 and TALAM1, long non-coding RNAs (lncRNAs). The second group involved patients with numerous microdeletions. The third group consisted of patients with a disrupted karyotype. The fourth group of patients did not show any CIN in adenomas. Overall, we identified frequent losses in genes, such as TSC2, COL1A1, NOTCH1, MIR4673, and GNAS, and gene gain containing MALAT1 and TALAM1. Since long non-coding RNA MALAT1 is associated with cancer cell metastasis and migration, its gene amplification represents an important event for adenoma development. 相似文献
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Ilija Ilić Peter Kása Jr. Klara Pintye-Hódi Stane Srčič 《Drug development and industrial pharmacy》2013,39(10):1271-1280
Objective: The purpose of this study was to investigate and quantify flow properties, compressibility, and compactibility of various pharmaceutical lactose powders found on the market today (DCL-11, DCL-21, M‐200, Flowlac-100, and Tablettose 70, 80, and 100). Methods: Flow properties were estimated by measuring flow time, angle of repose, and the Hausner ratio. Particle rearrangement was studied using Kawakita's linear model. Compressibility was studied using two ‘out-of-die’ methods: (i) the Heckel model and (ii) a modified Walker model. Compactibility was quantified using two methods: (i) the tensile strength profile (Cp) and (ii) the compactibility factor (Pr). Statistical approach was used to analyze the results. Results: Flow properties of all materials were passable or better, except for M-200, which has very poor flowability. Compressibility results demonstrated that the most compressible lactose is spray-dried grade of lactose (Flowlac-100) and the least compressible is milled lactose (M-200). Compactibility studies showed that β‐lactose (DCL-21) forms tablets with superior tensile strength in comparison with α-lactose. Conclusion: Results of the compressibility study showed that the discriminative power of modified Walker model is greater in comparison with Heckel model. Compactibility methods yield similar and comparable results. 相似文献
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Stephen D. Fried Kosuke Fujishima Mikhail Makarov Ivan Cherepashuk Klara Hlouchova 《Journal of the Royal Society Interface》2022,19(187)
Recent developments in Origins of Life research have focused on substantiating the narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular weight, a paradigm that typically sidelines the roles of peptides. Nevertheless, the simple synthesis of amino acids, the facile nature of their activation and condensation, their ability to recognize metals and cofactors and their remarkable capacity to self-assemble make peptides (and their analogues) favourable candidates for one of the earliest functional polymers. In this mini-review, we explore the ramifications of this hypothesis. Diverse lines of research in molecular biology, bioinformatics, geochemistry, biophysics and astrobiology provide clues about the progression and early evolution of proteins, and lend credence to the idea that early peptides served many central prebiotic roles before they were encodable by a polynucleotide template, in a putative ‘peptide-polynucleotide stage’. For example, early peptides and mini-proteins could have served as catalysts, compartments and structural hubs. In sum, we shed light on the role of early peptides and small proteins before and during the nucleotide world, in which nascent life fully grasped the potential of primordial proteins, and which has left an imprint on the idiosyncratic properties of extant proteins. 相似文献